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Gene: CTSH |
Gene summary for CTSH |
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Gene information | Species | Human | Gene symbol | CTSH | Gene ID | 1512 |
Gene name | cathepsin H | |
Gene Alias | ACC-4 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P09668 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1512 | CTSH | GSM4909282 | Human | Breast | IDC | 1.97e-11 | 4.21e-01 | -0.0288 |
1512 | CTSH | GSM4909291 | Human | Breast | IDC | 2.29e-10 | 4.99e-01 | 0.1753 |
1512 | CTSH | GSM4909304 | Human | Breast | IDC | 3.07e-02 | -1.28e-01 | 0.1636 |
1512 | CTSH | GSM4909305 | Human | Breast | IDC | 2.23e-05 | 3.15e-01 | 0.0436 |
1512 | CTSH | GSM4909306 | Human | Breast | IDC | 3.34e-03 | 2.95e-01 | 0.1564 |
1512 | CTSH | GSM4909311 | Human | Breast | IDC | 3.27e-05 | -2.05e-02 | 0.1534 |
1512 | CTSH | GSM4909319 | Human | Breast | IDC | 3.46e-08 | -8.06e-02 | 0.1563 |
1512 | CTSH | GSM4909321 | Human | Breast | IDC | 2.87e-03 | 2.24e-01 | 0.1559 |
1512 | CTSH | NCCBC11 | Human | Breast | DCIS | 9.89e-03 | 4.69e-01 | 0.1232 |
1512 | CTSH | NCCBC14 | Human | Breast | DCIS | 3.87e-04 | 2.46e-01 | 0.2021 |
1512 | CTSH | NCCBC3 | Human | Breast | DCIS | 2.42e-12 | 5.40e-01 | 0.1198 |
1512 | CTSH | NCCBC5 | Human | Breast | DCIS | 1.50e-09 | 4.71e-01 | 0.2046 |
1512 | CTSH | DCIS2 | Human | Breast | DCIS | 4.62e-54 | 2.55e-01 | 0.0085 |
1512 | CTSH | CA_HPV_1 | Human | Cervix | CC | 6.80e-03 | 2.50e-01 | 0.0264 |
1512 | CTSH | CA_HPV_3 | Human | Cervix | CC | 1.08e-04 | -2.50e-02 | 0.0414 |
1512 | CTSH | N_HPV_2 | Human | Cervix | N_HPV | 1.89e-03 | 1.07e-01 | -0.0131 |
1512 | CTSH | CCI_2 | Human | Cervix | CC | 1.06e-04 | -5.88e-01 | 0.5249 |
1512 | CTSH | CCI_3 | Human | Cervix | CC | 1.14e-06 | -5.70e-01 | 0.516 |
1512 | CTSH | CCII_1 | Human | Cervix | CC | 9.97e-03 | -3.90e-01 | 0.3249 |
1512 | CTSH | Tumor | Human | Cervix | CC | 2.81e-06 | 1.33e-01 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00604415 | Thyroid | HT | epithelial tube branching involved in lung morphogenesis | 7/1272 | 29/18723 | 2.73e-03 | 2.25e-02 | 7 |
GO:00018228 | Thyroid | HT | kidney development | 33/1272 | 293/18723 | 2.98e-03 | 2.40e-02 | 33 |
GO:000165516 | Thyroid | HT | urogenital system development | 36/1272 | 338/18723 | 4.99e-03 | 3.36e-02 | 36 |
GO:200105625 | Thyroid | HT | positive regulation of cysteine-type endopeptidase activity | 19/1272 | 148/18723 | 5.50e-03 | 3.62e-02 | 19 |
GO:004328025 | Thyroid | HT | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 17/1272 | 129/18723 | 6.45e-03 | 4.03e-02 | 17 |
GO:00024567 | Thyroid | HT | T cell mediated immunity | 15/1272 | 109/18723 | 6.84e-03 | 4.19e-02 | 15 |
GO:0031647113 | Thyroid | PTC | regulation of protein stability | 174/5968 | 298/18723 | 2.05e-21 | 4.05e-19 | 174 |
GO:2001233113 | Thyroid | PTC | regulation of apoptotic signaling pathway | 197/5968 | 356/18723 | 2.58e-20 | 3.69e-18 | 197 |
GO:0045862113 | Thyroid | PTC | positive regulation of proteolysis | 198/5968 | 372/18723 | 6.68e-18 | 6.91e-16 | 198 |
GO:2001235112 | Thyroid | PTC | positive regulation of apoptotic signaling pathway | 69/5968 | 126/18723 | 8.51e-08 | 1.73e-06 | 69 |
GO:000182215 | Thyroid | PTC | kidney development | 133/5968 | 293/18723 | 7.57e-07 | 1.18e-05 | 133 |
GO:00336197 | Thyroid | PTC | membrane protein proteolysis | 36/5968 | 57/18723 | 1.16e-06 | 1.69e-05 | 36 |
GO:000165517 | Thyroid | PTC | urogenital system development | 149/5968 | 338/18723 | 1.41e-06 | 2.01e-05 | 149 |
GO:005160420 | Thyroid | PTC | protein maturation | 132/5968 | 294/18723 | 1.71e-06 | 2.39e-05 | 132 |
GO:007200114 | Thyroid | PTC | renal system development | 135/5968 | 302/18723 | 1.76e-06 | 2.43e-05 | 135 |
GO:0043281113 | Thyroid | PTC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 99/5968 | 209/18723 | 1.93e-06 | 2.64e-05 | 99 |
GO:0010952113 | Thyroid | PTC | positive regulation of peptidase activity | 94/5968 | 197/18723 | 2.34e-06 | 3.11e-05 | 94 |
GO:0019882112 | Thyroid | PTC | antigen processing and presentation | 57/5968 | 106/18723 | 2.40e-06 | 3.17e-05 | 57 |
GO:0001667112 | Thyroid | PTC | ameboidal-type cell migration | 198/5968 | 475/18723 | 3.36e-06 | 4.34e-05 | 198 |
GO:0010634111 | Thyroid | PTC | positive regulation of epithelial cell migration | 85/5968 | 176/18723 | 3.83e-06 | 4.80e-05 | 85 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0421022 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0421032 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0421041 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
hsa0421051 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
hsa042109 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421014 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421023 | Cervix | HSIL_HPV | Apoptosis | 16/459 | 136/8465 | 2.74e-03 | 1.78e-02 | 1.44e-02 | 16 |
hsa0421033 | Cervix | HSIL_HPV | Apoptosis | 16/459 | 136/8465 | 2.74e-03 | 1.78e-02 | 1.44e-02 | 16 |
hsa0421042 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
hsa0421052 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa04210 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa042101 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa0421010 | Endometrium | AEH | Apoptosis | 30/1197 | 136/8465 | 7.72e-03 | 4.05e-02 | 2.96e-02 | 30 |
hsa0421015 | Endometrium | AEH | Apoptosis | 30/1197 | 136/8465 | 7.72e-03 | 4.05e-02 | 2.96e-02 | 30 |
hsa0421024 | Endometrium | EEC | Apoptosis | 31/1237 | 136/8465 | 6.72e-03 | 3.25e-02 | 2.42e-02 | 31 |
hsa0421034 | Endometrium | EEC | Apoptosis | 31/1237 | 136/8465 | 6.72e-03 | 3.25e-02 | 2.42e-02 | 31 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTSH | SNV | Missense_Mutation | novel | c.361N>A | p.Asp121Asn | p.D121N | P09668 | protein_coding | tolerated(0.05) | probably_damaging(0.926) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CTSH | SNV | Missense_Mutation | c.760N>C | p.Glu254Gln | p.E254Q | P09668 | protein_coding | tolerated(0.51) | possibly_damaging(0.714) | TCGA-C5-A1M6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
CTSH | SNV | Missense_Mutation | c.760N>C | p.Glu254Gln | p.E254Q | P09668 | protein_coding | tolerated(0.51) | possibly_damaging(0.714) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
CTSH | SNV | Missense_Mutation | novel | c.389C>T | p.Ser130Leu | p.S130L | P09668 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
CTSH | SNV | Missense_Mutation | c.526T>C | p.Phe176Leu | p.F176L | P09668 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CTSH | SNV | Missense_Mutation | novel | c.723N>T | p.Glu241Asp | p.E241D | P09668 | protein_coding | tolerated(0.46) | benign(0.006) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CTSH | SNV | Missense_Mutation | rs543936667 | c.34G>A | p.Ala12Thr | p.A12T | P09668 | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
CTSH | SNV | Missense_Mutation | rs747510233 | c.706N>A | p.Glu236Lys | p.E236K | P09668 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CTSH | SNV | Missense_Mutation | novel | c.517N>A | p.Ala173Thr | p.A173T | P09668 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CTSH | SNV | Missense_Mutation | c.469N>A | p.Ala157Thr | p.A157T | P09668 | protein_coding | tolerated(0.2) | benign(0.039) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1512 | CTSH | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 336446936 | ||
1512 | CTSH | DRUGGABLE GENOME, ENZYME, PROTEASE | inhibitor | 252166814 |
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