GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434073 | Oral cavity | OSCC | negative regulation of MAP kinase activity | 39/7305 | 59/18723 | 2.28e-05 | 2.16e-04 | 39 |
GO:00420587 | Oral cavity | OSCC | regulation of epidermal growth factor receptor signaling pathway | 46/7305 | 73/18723 | 2.80e-05 | 2.59e-04 | 46 |
GO:00303084 | Oral cavity | OSCC | negative regulation of cell growth | 101/7305 | 188/18723 | 2.85e-05 | 2.63e-04 | 101 |
GO:005086315 | Oral cavity | OSCC | regulation of T cell activation | 161/7305 | 329/18723 | 1.44e-04 | 1.02e-03 | 161 |
GO:19011858 | Oral cavity | OSCC | negative regulation of ERBB signaling pathway | 23/7305 | 32/18723 | 1.67e-04 | 1.14e-03 | 23 |
GO:00508527 | Oral cavity | OSCC | T cell receptor signaling pathway | 68/7305 | 123/18723 | 1.80e-04 | 1.22e-03 | 68 |
GO:000715916 | Oral cavity | OSCC | leukocyte cell-cell adhesion | 178/7305 | 371/18723 | 2.44e-04 | 1.57e-03 | 178 |
GO:190303715 | Oral cavity | OSCC | regulation of leukocyte cell-cell adhesion | 162/7305 | 336/18723 | 3.39e-04 | 2.08e-03 | 162 |
GO:00182123 | Oral cavity | OSCC | peptidyl-tyrosine modification | 180/7305 | 378/18723 | 3.63e-04 | 2.22e-03 | 180 |
GO:000268310 | Oral cavity | OSCC | negative regulation of immune system process | 204/7305 | 434/18723 | 3.72e-04 | 2.27e-03 | 204 |
GO:00420598 | Oral cavity | OSCC | negative regulation of epidermal growth factor receptor signaling pathway | 20/7305 | 28/18723 | 5.13e-04 | 2.99e-03 | 20 |
GO:0050730 | Oral cavity | OSCC | regulation of peptidyl-tyrosine phosphorylation | 129/7305 | 264/18723 | 6.70e-04 | 3.75e-03 | 129 |
GO:00181083 | Oral cavity | OSCC | peptidyl-tyrosine phosphorylation | 177/7305 | 375/18723 | 6.86e-04 | 3.83e-03 | 177 |
GO:004209816 | Oral cavity | OSCC | T cell proliferation | 100/7305 | 199/18723 | 7.93e-04 | 4.27e-03 | 100 |
GO:004308710 | Oral cavity | OSCC | regulation of GTPase activity | 165/7305 | 348/18723 | 7.94e-04 | 4.27e-03 | 165 |
GO:00480086 | Oral cavity | OSCC | platelet-derived growth factor receptor signaling pathway | 34/7305 | 56/18723 | 8.17e-04 | 4.35e-03 | 34 |
GO:00071629 | Oral cavity | OSCC | negative regulation of cell adhesion | 145/7305 | 303/18723 | 9.95e-04 | 5.18e-03 | 145 |
GO:00610996 | Oral cavity | OSCC | negative regulation of protein tyrosine kinase activity | 21/7305 | 31/18723 | 1.13e-03 | 5.75e-03 | 21 |
GO:0050732 | Oral cavity | OSCC | negative regulation of peptidyl-tyrosine phosphorylation | 35/7305 | 59/18723 | 1.24e-03 | 6.23e-03 | 35 |
GO:00466333 | Oral cavity | OSCC | alpha-beta T cell proliferation | 24/7305 | 38/18723 | 2.21e-03 | 1.00e-02 | 24 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa0412026 | Esophagus | HGIN | Ubiquitin mediated proteolysis | 49/1383 | 142/8465 | 7.78e-08 | 1.33e-06 | 1.06e-06 | 49 |
hsa0510039 | Esophagus | HGIN | Bacterial invasion of epithelial cells | 30/1383 | 77/8465 | 1.49e-06 | 2.31e-05 | 1.84e-05 | 30 |
hsa0520528 | Esophagus | HGIN | Proteoglycans in cancer | 47/1383 | 205/8465 | 8.23e-03 | 4.71e-02 | 3.74e-02 | 47 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04120111 | Esophagus | HGIN | Ubiquitin mediated proteolysis | 49/1383 | 142/8465 | 7.78e-08 | 1.33e-06 | 1.06e-06 | 49 |
hsa05100114 | Esophagus | HGIN | Bacterial invasion of epithelial cells | 30/1383 | 77/8465 | 1.49e-06 | 2.31e-05 | 1.84e-05 | 30 |
hsa05205112 | Esophagus | HGIN | Proteoglycans in cancer | 47/1383 | 205/8465 | 8.23e-03 | 4.71e-02 | 3.74e-02 | 47 |
hsa0412027 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0522020 | Esophagus | ESCC | Chronic myeloid leukemia | 61/4205 | 76/8465 | 3.20e-08 | 2.68e-07 | 1.37e-07 | 61 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa05100211 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
hsa049109 | Esophagus | ESCC | Insulin signaling pathway | 89/4205 | 137/8465 | 1.97e-04 | 7.32e-04 | 3.75e-04 | 89 |
hsa0401218 | Esophagus | ESCC | ErbB signaling pathway | 56/4205 | 85/8465 | 1.78e-03 | 5.24e-03 | 2.68e-03 | 56 |
hsa0412036 | Esophagus | ESCC | Ubiquitin mediated proteolysis | 122/4205 | 142/8465 | 6.53e-20 | 7.29e-18 | 3.74e-18 | 122 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa05220110 | Esophagus | ESCC | Chronic myeloid leukemia | 61/4205 | 76/8465 | 3.20e-08 | 2.68e-07 | 1.37e-07 | 61 |
hsa0520537 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa05100310 | Esophagus | ESCC | Bacterial invasion of epithelial cells | 59/4205 | 77/8465 | 1.05e-06 | 6.76e-06 | 3.46e-06 | 59 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CBL | SNV | Missense_Mutation | rs759585425 | c.1028N>A | p.Arg343Gln | p.R343Q | P22681 | protein_coding | tolerated(0.07) | possibly_damaging(0.68) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CBL | SNV | Missense_Mutation | | c.397N>C | p.Phe133Leu | p.F133L | P22681 | protein_coding | tolerated(0.22) | probably_damaging(1) | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CBL | SNV | Missense_Mutation | | c.293N>C | p.Ile98Thr | p.I98T | P22681 | protein_coding | deleterious(0.02) | benign(0.422) | TCGA-AR-A24S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
CBL | SNV | Missense_Mutation | novel | c.1501N>C | p.Asp501His | p.D501H | P22681 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CBL | SNV | Missense_Mutation | | c.1619N>C | p.Arg540Pro | p.R540P | P22681 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.997) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CBL | deletion | Frame_Shift_Del | novel | c.2287delN | p.Gly763ValfsTer103 | p.G763Vfs*103 | P22681 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CBL | SNV | Missense_Mutation | novel | c.570N>C | p.Trp190Cys | p.W190C | P22681 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CBL | SNV | Missense_Mutation | | c.1366N>A | p.Asp456Asn | p.D456N | P22681 | protein_coding | deleterious(0) | benign(0.439) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CBL | SNV | Missense_Mutation | | c.416N>T | p.Arg139Ile | p.R139I | P22681 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CBL | SNV | Missense_Mutation | | c.617N>A | p.Arg206Gln | p.R206Q | P22681 | protein_coding | tolerated(0.09) | probably_damaging(0.978) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | Fasudil | FASUDIL | 26177294 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | ANTISENSE OLIGONUCLEOTIDES | | 8849724 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | Gemcitabine | GEMCITABINE | 25348515 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | DASATINIB | DASATINIB | 23696637 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | SU11274 | | 28835699 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | N/A | | 26230957,23690417,19901108 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | Quizartinib | QUIZARTINIB | 22990016 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | IL-2 | ALDESLEUKIN | 9461587 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | Erlotinib | ERLOTINIB | 25348515 |
867 | CBL | KINASE, ENZYME, CLINICALLY ACTIONABLE | | FLT3-LIGAND | | 17446348 |