Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/ZBTB20_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/ZBTB20_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/ZBTB20_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/ZBTB20_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/ZBTB20_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/ZBTB20_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/ZBTB20_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/ZBTB20_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/ZBTB20_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/ZBTB20_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/ZBTB20_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/ZBTB20_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/ZBTB20_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19035788 | Lung | IAC | regulation of ATP metabolic process | 19/2061 | 87/18723 | 2.56e-03 | 2.37e-02 | 19 |
GO:00196937 | Lung | IAC | ribose phosphate metabolic process | 62/2061 | 396/18723 | 2.72e-03 | 2.49e-02 | 62 |
GO:00342848 | Lung | IAC | response to monosaccharide | 39/2061 | 225/18723 | 2.75e-03 | 2.51e-02 | 39 |
GO:000989613 | Lung | AIS | positive regulation of catabolic process | 103/1849 | 492/18723 | 9.59e-14 | 1.86e-10 | 103 |
GO:003133113 | Lung | AIS | positive regulation of cellular catabolic process | 89/1849 | 427/18723 | 6.12e-12 | 4.46e-09 | 89 |
GO:000974313 | Lung | AIS | response to carbohydrate | 45/1849 | 253/18723 | 7.09e-05 | 1.88e-03 | 45 |
GO:000915013 | Lung | AIS | purine ribonucleotide metabolic process | 58/1849 | 368/18723 | 2.33e-04 | 4.68e-03 | 58 |
GO:003428413 | Lung | AIS | response to monosaccharide | 39/1849 | 225/18723 | 3.59e-04 | 6.39e-03 | 39 |
GO:000925913 | Lung | AIS | ribonucleotide metabolic process | 59/1849 | 385/18723 | 4.36e-04 | 7.41e-03 | 59 |
GO:000616313 | Lung | AIS | purine nucleotide metabolic process | 59/1849 | 396/18723 | 8.91e-04 | 1.20e-02 | 59 |
GO:001969313 | Lung | AIS | ribose phosphate metabolic process | 59/1849 | 396/18723 | 8.91e-04 | 1.20e-02 | 59 |
GO:007252113 | Lung | AIS | purine-containing compound metabolic process | 61/1849 | 416/18723 | 1.10e-03 | 1.42e-02 | 61 |
GO:00097468 | Lung | AIS | response to hexose | 35/1849 | 219/18723 | 2.95e-03 | 2.93e-02 | 35 |
GO:190358011 | Lung | AIS | positive regulation of ATP metabolic process | 10/1849 | 38/18723 | 3.07e-03 | 2.98e-02 | 10 |
GO:004603413 | Lung | AIS | ATP metabolic process | 42/1849 | 277/18723 | 3.31e-03 | 3.16e-02 | 42 |
GO:007252123 | Lung | AAH | purine-containing compound metabolic process | 32/613 | 416/18723 | 7.55e-06 | 1.82e-03 | 32 |
GO:000925923 | Lung | AAH | ribonucleotide metabolic process | 30/613 | 385/18723 | 1.13e-05 | 2.46e-03 | 30 |
GO:000915023 | Lung | AAH | purine ribonucleotide metabolic process | 29/613 | 368/18723 | 1.28e-05 | 2.66e-03 | 29 |
GO:000616323 | Lung | AAH | purine nucleotide metabolic process | 30/613 | 396/18723 | 1.94e-05 | 3.42e-03 | 30 |
GO:001969323 | Lung | AAH | ribose phosphate metabolic process | 30/613 | 396/18723 | 1.94e-05 | 3.42e-03 | 30 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB20 | SNV | Missense_Mutation | | c.1090N>A | p.Glu364Lys | p.E364K | Q9HC78 | protein_coding | deleterious(0.03) | probably_damaging(0.959) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZBTB20 | SNV | Missense_Mutation | novel | c.1864A>G | p.Ile622Val | p.I622V | Q9HC78 | protein_coding | tolerated(0.06) | possibly_damaging(0.727) | TCGA-AC-A62Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB20 | SNV | Missense_Mutation | novel | c.1824C>G | p.Cys608Trp | p.C608W | Q9HC78 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB20 | SNV | Missense_Mutation | | c.1120A>C | p.Ser374Arg | p.S374R | Q9HC78 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-BH-A18Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB20 | SNV | Missense_Mutation | rs779910215 | c.2155N>A | p.Val719Ile | p.V719I | Q9HC78 | protein_coding | tolerated_low_confidence(0.1) | probably_damaging(0.984) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD |
ZBTB20 | insertion | Nonsense_Mutation | novel | c.1688_1689insAGAACGTTGCTTAAGATAAACTTTGCCTTCTTTGCAGGGTAATGTAA | p.Ala564GlufsTer6 | p.A564Efs*6 | Q9HC78 | protein_coding | | | TCGA-A8-A08T-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
ZBTB20 | insertion | Frame_Shift_Ins | novel | c.1171_1172insGATCTCGATGTCGCTGTAGCCA | p.Glu391GlyfsTer22 | p.E391Gfs*22 | Q9HC78 | protein_coding | | | TCGA-AN-A0AS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZBTB20 | insertion | In_Frame_Ins | novel | c.1261_1262insATCCCCTTGCAACTGATGTCACCTGCAGCATGTCAA | p.Pro421delinsHisProLeuAlaThrAspValThrCysSerMetSerThr | p.P421delinsHPLATDVTCSMST | Q9HC78 | protein_coding | | | TCGA-AO-A0JE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
ZBTB20 | insertion | Frame_Shift_Ins | novel | c.1822_1823insATATTCTTGTGGAAGAGAAAAAGAAAAAGAAATGGAGGGTGGGG | p.Cys608TyrfsTer25 | p.C608Yfs*25 | Q9HC78 | protein_coding | | | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZBTB20 | deletion | Frame_Shift_Del | novel | c.284delN | p.Asn95ThrfsTer12 | p.N95Tfs*12 | Q9HC78 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |