GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00426921 | Lung | AIS | muscle cell differentiation | 58/1849 | 384/18723 | 7.00e-04 | 1.03e-02 | 58 |
GO:005080811 | Lung | AIS | synapse organization | 63/1849 | 426/18723 | 7.39e-04 | 1.07e-02 | 63 |
GO:003227313 | Lung | AIS | positive regulation of protein polymerization | 26/1849 | 138/18723 | 9.38e-04 | 1.24e-02 | 26 |
GO:003599411 | Lung | AIS | response to muscle stretch | 8/1849 | 23/18723 | 1.12e-03 | 1.44e-02 | 8 |
GO:19049518 | Lung | AIS | positive regulation of establishment of protein localization | 49/1849 | 319/18723 | 1.21e-03 | 1.54e-02 | 49 |
GO:009706111 | Lung | AIS | dendritic spine organization | 18/1849 | 84/18723 | 1.22e-03 | 1.55e-02 | 18 |
GO:0018212 | Lung | AIS | peptidyl-tyrosine modification | 56/1849 | 378/18723 | 1.35e-03 | 1.68e-02 | 56 |
GO:003253513 | Lung | AIS | regulation of cellular component size | 56/1849 | 383/18723 | 1.83e-03 | 2.05e-02 | 56 |
GO:0018108 | Lung | AIS | peptidyl-tyrosine phosphorylation | 55/1849 | 375/18723 | 1.87e-03 | 2.08e-02 | 55 |
GO:00605371 | Lung | AIS | muscle tissue development | 58/1849 | 403/18723 | 2.22e-03 | 2.37e-02 | 58 |
GO:190290513 | Lung | AIS | positive regulation of supramolecular fiber organization | 34/1849 | 209/18723 | 2.50e-03 | 2.57e-02 | 34 |
GO:000815413 | Lung | AIS | actin polymerization or depolymerization | 35/1849 | 218/18723 | 2.73e-03 | 2.75e-02 | 35 |
GO:000301211 | Lung | AIS | muscle system process | 63/1849 | 452/18723 | 3.18e-03 | 3.05e-02 | 63 |
GO:00109271 | Lung | AIS | cellular component assembly involved in morphogenesis | 20/1849 | 107/18723 | 3.79e-03 | 3.52e-02 | 20 |
GO:00300418 | Lung | AIS | actin filament polymerization | 31/1849 | 191/18723 | 3.90e-03 | 3.59e-02 | 31 |
GO:00511461 | Lung | AIS | striated muscle cell differentiation | 42/1849 | 283/18723 | 4.88e-03 | 4.24e-02 | 42 |
GO:003051611 | Lung | AIS | regulation of axon extension | 18/1849 | 95/18723 | 5.04e-03 | 4.35e-02 | 18 |
GO:00308338 | Lung | AIS | regulation of actin filament polymerization | 28/1849 | 172/18723 | 5.64e-03 | 4.76e-02 | 28 |
GO:001489611 | Lung | AIS | muscle hypertrophy | 19/1849 | 104/18723 | 6.07e-03 | 4.98e-02 | 19 |
GO:200123320 | Oral cavity | OSCC | regulation of apoptotic signaling pathway | 242/7305 | 356/18723 | 6.66e-29 | 3.24e-26 | 242 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTN | SNV | Missense_Mutation | rs557526069 | c.35041G>A | p.Glu11681Lys | p.E11681K | | protein_coding | | | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
TTN | SNV | Missense_Mutation | novel | c.31372N>C | p.Val10458Leu | p.V10458L | | protein_coding | | | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TTN | SNV | Missense_Mutation | | c.69142N>A | p.Glu23048Lys | p.E23048K | | protein_coding | | | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TTN | SNV | Missense_Mutation | novel | c.105331G>C | p.Glu35111Gln | p.E35111Q | | protein_coding | | | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TTN | SNV | Missense_Mutation | novel | c.91713G>A | p.Met30571Ile | p.M30571I | | protein_coding | | | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TTN | SNV | Missense_Mutation | | c.31520A>T | p.Glu10507Val | p.E10507V | | protein_coding | | | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | | SD |
TTN | SNV | Missense_Mutation | novel | c.43021N>A | p.Glu14341Lys | p.E14341K | | protein_coding | | | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
TTN | SNV | Missense_Mutation | | c.58960N>T | p.Val19654Phe | p.V19654F | | protein_coding | | | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
TTN | SNV | Missense_Mutation | novel | c.38183N>T | p.Lys12728Ile | p.K12728I | | protein_coding | | | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
TTN | SNV | Missense_Mutation | novel | c.10739C>G | p.Ala3580Gly | p.A3580G | | protein_coding | | | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |