Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SPTBN1

Gene summary for SPTBN1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SPTBN1

Gene ID

6711

Gene namespectrin beta, non-erythrocytic 1
Gene AliasDDISBA
Cytomap2p16.2
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

B2ZZ89


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6711SPTBN1HTA11_3410_2000001011HumanColorectumAD2.17e-05-3.88e-010.0155
6711SPTBN1HTA11_2487_2000001011HumanColorectumSER4.58e-045.93e-01-0.1808
6711SPTBN1HTA11_1938_2000001011HumanColorectumAD1.47e-096.52e-01-0.0811
6711SPTBN1HTA11_78_2000001011HumanColorectumAD3.89e-024.68e-01-0.1088
6711SPTBN1HTA11_347_2000001011HumanColorectumAD3.87e-157.59e-01-0.1954
6711SPTBN1HTA11_411_2000001011HumanColorectumSER2.02e-071.33e+00-0.2602
6711SPTBN1HTA11_1391_2000001011HumanColorectumAD1.03e-025.14e-01-0.059
6711SPTBN1HTA11_99999970781_79442HumanColorectumMSS3.40e-034.39e-010.294
6711SPTBN1A002-C-010HumanColorectumFAP9.37e-05-1.59e-010.242
6711SPTBN1A001-C-207HumanColorectumFAP2.58e-02-1.41e-010.1278
6711SPTBN1A015-C-203HumanColorectumFAP3.37e-33-3.84e-01-0.1294
6711SPTBN1A015-C-204HumanColorectumFAP6.13e-09-3.06e-01-0.0228
6711SPTBN1A014-C-040HumanColorectumFAP2.15e-03-3.21e-01-0.1184
6711SPTBN1A002-C-201HumanColorectumFAP1.61e-11-2.22e-010.0324
6711SPTBN1A002-C-203HumanColorectumFAP5.89e-03-1.66e-010.2786
6711SPTBN1A001-C-119HumanColorectumFAP1.10e-06-1.05e-01-0.1557
6711SPTBN1A001-C-108HumanColorectumFAP5.31e-20-6.14e-02-0.0272
6711SPTBN1A002-C-205HumanColorectumFAP8.24e-23-2.21e-01-0.1236
6711SPTBN1A001-C-104HumanColorectumFAP2.81e-041.13e-010.0184
6711SPTBN1A015-C-005HumanColorectumFAP3.44e-03-1.78e-01-0.0336
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003297018ProstateBPHregulation of actin filament-based process133/3107397/187237.07e-171.62e-14133
GO:190382918ProstateBPHpositive regulation of cellular protein localization98/3107276/187231.46e-141.84e-1298
GO:003295618ProstateBPHregulation of actin cytoskeleton organization118/3107358/187231.51e-141.87e-12118
GO:004819310ProstateBPHGolgi vesicle transport102/3107296/187233.90e-144.56e-12102
GO:004325418ProstateBPHregulation of protein-containing complex assembly133/3107428/187235.40e-146.08e-12133
GO:011005318ProstateBPHregulation of actin filament organization96/3107278/187231.90e-131.89e-1196
GO:005125818ProstateBPHprotein polymerization96/3107297/187231.52e-111.10e-0996
GO:003227118ProstateBPHregulation of protein polymerization80/3107233/187232.67e-111.78e-0980
GO:007265916ProstateBPHprotein localization to plasma membrane89/3107284/187235.00e-102.56e-0889
GO:000815416ProstateBPHactin polymerization or depolymerization72/3107218/187231.82e-097.59e-0872
GO:002241117ProstateBPHcellular component disassembly121/3107443/187236.34e-092.25e-07121
GO:003253517ProstateBPHregulation of cellular component size108/3107383/187236.41e-092.27e-07108
GO:003004116ProstateBPHactin filament polymerization63/3107191/187231.94e-085.98e-0763
GO:199077810ProstateBPHprotein localization to cell periphery95/3107333/187232.78e-088.13e-0795
GO:000806415ProstateBPHregulation of actin polymerization or depolymerization61/3107188/187236.37e-081.68e-0661
GO:003083316ProstateBPHregulation of actin filament polymerization57/3107172/187237.52e-081.92e-0657
GO:003083210ProstateBPHregulation of actin filament length61/3107189/187237.89e-082.00e-0661
GO:009015016ProstateBPHestablishment of protein localization to membrane77/3107260/187231.06e-072.56e-0677
GO:190290410ProstateBPHnegative regulation of supramolecular fiber organization55/3107167/187231.60e-073.63e-0655
GO:00009109ProstateBPHcytokinesis55/3107173/187235.81e-071.15e-0555
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SPTBN1SNVMissense_Mutationc.4936G>Ap.Glu1646Lysp.E1646KQ01082protein_codingtolerated(0.26)benign(0.035)TCGA-A1-A0SH-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytcSD
SPTBN1SNVMissense_Mutationc.124C>Tp.Arg42Trpp.R42WQ01082protein_codingdeleterious(0.02)probably_damaging(0.999)TCGA-A2-A0YT-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyarimidexSD
SPTBN1SNVMissense_Mutationc.3680N>Gp.Ala1227Glyp.A1227GQ01082protein_codingtolerated(0.9)benign(0.006)TCGA-AO-A124-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SPTBN1SNVMissense_Mutationnovelc.3749N>Gp.Val1250Glyp.V1250GQ01082protein_codingtolerated(0.05)benign(0.315)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SPTBN1SNVMissense_Mutationrs761483604c.4454N>Gp.Lys1485Argp.K1485RQ01082protein_codingtolerated(0.23)benign(0.181)TCGA-B6-A400-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
SPTBN1SNVMissense_Mutationc.6431N>Tp.Thr2144Metp.T2144MQ01082protein_codingtolerated(0.1)benign(0.068)TCGA-BH-A0HP-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapydoxorubicinSD
SPTBN1SNVMissense_Mutationc.3180G>Cp.Glu1060Aspp.E1060DQ01082protein_codingtolerated(0.08)possibly_damaging(0.737)TCGA-BH-A18T-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
SPTBN1SNVMissense_Mutationnovelc.4960N>Cp.Thr1654Prop.T1654PQ01082protein_codingdeleterious(0.04)possibly_damaging(0.511)TCGA-BH-A1F8-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownPD
SPTBN1SNVMissense_Mutationc.1325N>Cp.Gln442Prop.Q442PQ01082protein_codingdeleterious(0)probably_damaging(0.998)TCGA-D8-A1XK-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicine+cyclophosphamideSD
SPTBN1insertionFrame_Shift_Insnovelc.5112_5113insTGGAGAATCAGATGGAAGTGp.Arg1705TrpfsTer163p.R1705Wfs*163Q01082protein_codingTCGA-A2-A0EY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6711SPTBN1NAABT-413
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