Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SMURF1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SMURF1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SMURF1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/SMURF1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SMURF1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SMURF1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SMURF1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SMURF1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SMURF1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SMURF1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SMURF1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:019873822 | Lung | AAH | cell-cell signaling by wnt | 28/613 | 446/18723 | 8.18e-04 | 2.75e-02 | 28 |
GO:190305222 | Lung | AAH | positive regulation of proteolysis involved in cellular protein catabolic process | 12/613 | 133/18723 | 1.42e-03 | 3.69e-02 | 12 |
GO:004863921 | Lung | AAH | positive regulation of developmental growth | 14/613 | 174/18723 | 1.80e-03 | 4.22e-02 | 14 |
GO:004217633 | Lung | MIAC | regulation of protein catabolic process | 47/967 | 391/18723 | 6.27e-08 | 2.15e-05 | 47 |
GO:000989632 | Lung | MIAC | positive regulation of catabolic process | 54/967 | 492/18723 | 1.42e-07 | 3.64e-05 | 54 |
GO:001605531 | Lung | MIAC | Wnt signaling pathway | 50/967 | 444/18723 | 1.88e-07 | 4.02e-05 | 50 |
GO:019873831 | Lung | MIAC | cell-cell signaling by wnt | 50/967 | 446/18723 | 2.16e-07 | 4.11e-05 | 50 |
GO:190336233 | Lung | MIAC | regulation of cellular protein catabolic process | 34/967 | 255/18723 | 3.83e-07 | 6.52e-05 | 34 |
GO:002260432 | Lung | MIAC | regulation of cell morphogenesis | 38/967 | 309/18723 | 6.47e-07 | 9.76e-05 | 38 |
GO:003133132 | Lung | MIAC | positive regulation of cellular catabolic process | 46/967 | 427/18723 | 2.00e-06 | 2.44e-04 | 46 |
GO:004573232 | Lung | MIAC | positive regulation of protein catabolic process | 30/967 | 231/18723 | 3.16e-06 | 3.45e-04 | 30 |
GO:190305033 | Lung | MIAC | regulation of proteolysis involved in cellular protein catabolic process | 28/967 | 221/18723 | 1.07e-05 | 8.86e-04 | 28 |
GO:200005833 | Lung | MIAC | regulation of ubiquitin-dependent protein catabolic process | 23/967 | 164/18723 | 1.24e-05 | 9.79e-04 | 23 |
GO:190336432 | Lung | MIAC | positive regulation of cellular protein catabolic process | 22/967 | 155/18723 | 1.57e-05 | 1.07e-03 | 22 |
GO:200006023 | Lung | MIAC | positive regulation of ubiquitin-dependent protein catabolic process | 17/967 | 107/18723 | 3.31e-05 | 1.91e-03 | 17 |
GO:007155922 | Lung | MIAC | response to transforming growth factor beta | 28/967 | 256/18723 | 1.51e-04 | 5.95e-03 | 28 |
GO:007265922 | Lung | MIAC | protein localization to plasma membrane | 30/967 | 284/18723 | 1.66e-04 | 6.31e-03 | 30 |
GO:190305231 | Lung | MIAC | positive regulation of proteolysis involved in cellular protein catabolic process | 18/967 | 133/18723 | 1.68e-04 | 6.31e-03 | 18 |
GO:006056021 | Lung | MIAC | developmental growth involved in morphogenesis | 26/967 | 234/18723 | 1.99e-04 | 7.15e-03 | 26 |
GO:199013821 | Lung | MIAC | neuron projection extension | 21/967 | 172/18723 | 2.21e-04 | 7.66e-03 | 21 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMURF1 | SNV | Missense_Mutation | novel | c.1204N>A | p.Glu402Lys | p.E402K | Q9HCE7 | protein_coding | tolerated(0.6) | probably_damaging(0.979) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SMURF1 | SNV | Missense_Mutation | | c.1681G>A | p.Ala561Thr | p.A561T | Q9HCE7 | protein_coding | tolerated(0.17) | possibly_damaging(0.728) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMURF1 | SNV | Missense_Mutation | novel | c.853N>C | p.Phe285Leu | p.F285L | Q9HCE7 | protein_coding | tolerated(0.79) | benign(0) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
SMURF1 | insertion | Frame_Shift_Ins | novel | c.485_486insAGTGCTCTGGAAAGGAGAGCATGGGGCGAGATGGAGAAGA | p.Tyr163ValfsTer15 | p.Y163Vfs*15 | Q9HCE7 | protein_coding | | | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
SMURF1 | insertion | Frame_Shift_Ins | novel | c.1452_1453insA | p.His485ThrfsTer53 | p.H485Tfs*53 | Q9HCE7 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMURF1 | insertion | Frame_Shift_Ins | novel | c.1451_1452insGTCGGGGCTCCTGGTTGTGTCCCATGTGT | p.Asp484GlufsTer70 | p.D484Efs*70 | Q9HCE7 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMURF1 | deletion | Frame_Shift_Del | novel | c.1077delN | p.Ser360ValfsTer19 | p.S360Vfs*19 | Q9HCE7 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
SMURF1 | SNV | Missense_Mutation | novel | c.1280G>A | p.Arg427Gln | p.R427Q | Q9HCE7 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SMURF1 | SNV | Missense_Mutation | novel | c.1400C>T | p.Thr467Met | p.T467M | Q9HCE7 | protein_coding | deleterious(0.02) | probably_damaging(0.909) | TCGA-C5-A7UI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SMURF1 | SNV | Missense_Mutation | novel | c.85N>C | p.Asp29His | p.D29H | Q9HCE7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-VS-A8QM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |