Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/PRKCA_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PRKCA_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PRKCA_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PRKCA_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/PRKCA_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PRKCA_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PRKCA_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PRKCA_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PRKCA_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PRKCA_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PRKCA_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00434101 | Lung | AIS | positive regulation of MAPK cascade | 72/1849 | 480/18723 | 2.11e-04 | 4.32e-03 | 72 |
GO:004348812 | Lung | AIS | regulation of mRNA stability | 30/1849 | 158/18723 | 3.46e-04 | 6.25e-03 | 30 |
GO:006101312 | Lung | AIS | regulation of mRNA catabolic process | 31/1849 | 166/18723 | 3.77e-04 | 6.61e-03 | 31 |
GO:009013211 | Lung | AIS | epithelium migration | 56/1849 | 360/18723 | 4.14e-04 | 7.14e-03 | 56 |
GO:0070371 | Lung | AIS | ERK1 and ERK2 cascade | 52/1849 | 330/18723 | 4.80e-04 | 7.95e-03 | 52 |
GO:001063211 | Lung | AIS | regulation of epithelial cell migration | 47/1849 | 292/18723 | 5.47e-04 | 8.65e-03 | 47 |
GO:004348712 | Lung | AIS | regulation of RNA stability | 31/1849 | 170/18723 | 5.76e-04 | 8.97e-03 | 31 |
GO:009013011 | Lung | AIS | tissue migration | 56/1849 | 365/18723 | 5.85e-04 | 9.03e-03 | 56 |
GO:001063111 | Lung | AIS | epithelial cell migration | 55/1849 | 357/18723 | 5.89e-04 | 9.03e-03 | 55 |
GO:00508788 | Lung | AIS | regulation of body fluid levels | 57/1849 | 379/18723 | 8.60e-04 | 1.17e-02 | 57 |
GO:0070372 | Lung | AIS | regulation of ERK1 and ERK2 cascade | 48/1849 | 309/18723 | 1.06e-03 | 1.38e-02 | 48 |
GO:000640112 | Lung | AIS | RNA catabolic process | 44/1849 | 278/18723 | 1.15e-03 | 1.47e-02 | 44 |
GO:004563713 | Lung | AIS | regulation of myeloid cell differentiation | 35/1849 | 210/18723 | 1.43e-03 | 1.74e-02 | 35 |
GO:005067312 | Lung | AIS | epithelial cell proliferation | 62/1849 | 437/18723 | 2.26e-03 | 2.39e-02 | 62 |
GO:000189412 | Lung | AIS | tissue homeostasis | 41/1849 | 268/18723 | 3.13e-03 | 3.01e-02 | 41 |
GO:000301211 | Lung | AIS | muscle system process | 63/1849 | 452/18723 | 3.18e-03 | 3.05e-02 | 63 |
GO:002240711 | Lung | AIS | regulation of cell-cell adhesion | 62/1849 | 448/18723 | 4.01e-03 | 3.65e-02 | 62 |
GO:001063412 | Lung | AIS | positive regulation of epithelial cell migration | 29/1849 | 176/18723 | 4.12e-03 | 3.68e-02 | 29 |
GO:001489611 | Lung | AIS | muscle hypertrophy | 19/1849 | 104/18723 | 6.07e-03 | 4.98e-02 | 19 |
GO:190331122 | Lung | AAH | regulation of mRNA metabolic process | 25/613 | 288/18723 | 9.84e-06 | 2.25e-03 | 25 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0541520 | Cervix | CC | Diabetic cardiomyopathy | 76/1267 | 203/8465 | 1.40e-15 | 6.46e-14 | 3.82e-14 | 76 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0541720 | Cervix | CC | Lipid and atherosclerosis | 65/1267 | 215/8465 | 6.47e-09 | 1.10e-07 | 6.52e-08 | 65 |
hsa0516318 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0451010 | Cervix | CC | Focal adhesion | 59/1267 | 203/8465 | 1.53e-07 | 1.84e-06 | 1.09e-06 | 59 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0466612 | Cervix | CC | Fc gamma R-mediated phagocytosis | 31/1267 | 97/8465 | 1.78e-05 | 1.42e-04 | 8.40e-05 | 31 |
hsa0472318 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa0517016 | Cervix | CC | Human immunodeficiency virus 1 infection | 55/1267 | 212/8465 | 1.80e-05 | 1.42e-04 | 8.40e-05 | 55 |
hsa0401210 | Cervix | CC | ErbB signaling pathway | 28/1267 | 85/8465 | 2.40e-05 | 1.82e-04 | 1.08e-04 | 28 |
hsa0407110 | Cervix | CC | Sphingolipid signaling pathway | 35/1267 | 121/8465 | 5.70e-05 | 3.93e-04 | 2.32e-04 | 35 |
hsa043609 | Cervix | CC | Axon guidance | 47/1267 | 182/8465 | 8.13e-05 | 5.38e-04 | 3.18e-04 | 47 |
hsa052148 | Cervix | CC | Glioma | 24/1267 | 75/8465 | 1.51e-04 | 9.20e-04 | 5.44e-04 | 24 |
hsa0511016 | Cervix | CC | Vibrio cholerae infection | 18/1267 | 50/8465 | 1.91e-04 | 1.11e-03 | 6.55e-04 | 18 |
hsa04664 | Cervix | CC | Fc epsilon RI signaling pathway | 22/1267 | 68/8465 | 2.35e-04 | 1.31e-03 | 7.77e-04 | 22 |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0516414 | Cervix | CC | Influenza A | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRKCA | SNV | Missense_Mutation | novel | c.756N>T | p.Arg252Ser | p.R252S | P17252 | protein_coding | tolerated(0.14) | benign(0.1) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
PRKCA | SNV | Missense_Mutation | rs776243082 | c.430N>A | p.Val144Ile | p.V144I | P17252 | protein_coding | tolerated(0.19) | benign(0.059) | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD |
PRKCA | SNV | Missense_Mutation | novel | c.1621N>A | p.Glu541Lys | p.E541K | P17252 | protein_coding | deleterious(0.01) | benign(0.397) | TCGA-AN-A0FZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PRKCA | insertion | Frame_Shift_Ins | novel | c.788_789insGGCA | p.Ser264AlafsTer17 | p.S264Afs*17 | P17252 | protein_coding | | | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD |
PRKCA | insertion | Frame_Shift_Ins | novel | c.789_790insGATCTCAGCTCACTGCAGCCTCCGCC | p.Ser264AspfsTer12 | p.S264Dfs*12 | P17252 | protein_coding | | | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD |
PRKCA | insertion | Nonsense_Mutation | novel | c.353_354insAATGATCCATTTAGGGTTGTTCTGTTCACTTCACAAACACACCGATT | p.Cys118Ter | p.C118* | P17252 | protein_coding | | | TCGA-BH-A1FD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PRKCA | SNV | Missense_Mutation | novel | c.1663N>A | p.Val555Ile | p.V555I | P17252 | protein_coding | tolerated(0.07) | benign(0.213) | TCGA-HM-A3JJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PRKCA | SNV | Missense_Mutation | rs140466753 | c.1895G>A | p.Arg632Gln | p.R632Q | P17252 | protein_coding | tolerated(0.07) | benign(0.029) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PRKCA | SNV | Missense_Mutation | novel | c.1627G>A | p.Glu543Lys | p.E543K | P17252 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PRKCA | SNV | Missense_Mutation | | c.916N>A | p.Glu306Lys | p.E306K | P17252 | protein_coding | tolerated(0.15) | benign(0.014) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | 178102320 | ENZASTAURIN | |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | BRYOSTATIN | BRYOSTATIN | 22579485 |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | SOPHORETIN | QUERCETIN | |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | Sodium phenylbutyrate | | |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | 178101880 | | |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | hydrochlorothiazide | HYDROCHLOROTHIAZIDE | |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | MIDOSTAURIN | MIDOSTAURIN | |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | BRYOSTATIN-1 | | |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | inhibitor | 178102596 | | |
5578 | PRKCA | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, CLINICALLY ACTIONABLE, ENZYME | | ENOXOLONE | ENOXOLONE | 24461294 |