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Gene: PMAIP1 |
Gene summary for PMAIP1 |
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Gene information | Species | Human | Gene symbol | PMAIP1 | Gene ID | 5366 |
Gene name | phorbol-12-myristate-13-acetate-induced protein 1 | |
Gene Alias | APR | |
Cytomap | 18q21.32 | |
Gene Type | protein-coding | GO ID | GO:0001666 | UniProtAcc | A0A0S2Z490 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5366 | PMAIP1 | GSM4909280 | Human | Breast | Precancer | 4.79e-03 | 5.32e-01 | 0.0305 |
5366 | PMAIP1 | GSM4909282 | Human | Breast | IDC | 1.57e-25 | 7.28e-01 | -0.0288 |
5366 | PMAIP1 | GSM4909286 | Human | Breast | IDC | 1.20e-03 | -3.68e-01 | 0.1081 |
5366 | PMAIP1 | GSM4909287 | Human | Breast | IDC | 5.61e-07 | 4.21e-01 | 0.2057 |
5366 | PMAIP1 | GSM4909290 | Human | Breast | IDC | 9.55e-06 | -4.00e-01 | 0.2096 |
5366 | PMAIP1 | GSM4909291 | Human | Breast | IDC | 3.86e-06 | -4.25e-01 | 0.1753 |
5366 | PMAIP1 | GSM4909294 | Human | Breast | IDC | 8.31e-13 | -4.30e-01 | 0.2022 |
5366 | PMAIP1 | GSM4909296 | Human | Breast | IDC | 1.81e-07 | -3.20e-01 | 0.1524 |
5366 | PMAIP1 | GSM4909297 | Human | Breast | IDC | 1.25e-09 | -2.50e-01 | 0.1517 |
5366 | PMAIP1 | GSM4909306 | Human | Breast | IDC | 4.61e-02 | -2.93e-01 | 0.1564 |
5366 | PMAIP1 | GSM4909307 | Human | Breast | IDC | 1.55e-03 | -3.30e-01 | 0.1569 |
5366 | PMAIP1 | GSM4909311 | Human | Breast | IDC | 2.53e-19 | -4.48e-01 | 0.1534 |
5366 | PMAIP1 | GSM4909312 | Human | Breast | IDC | 4.33e-13 | -4.03e-01 | 0.1552 |
5366 | PMAIP1 | GSM4909319 | Human | Breast | IDC | 5.48e-20 | -4.35e-01 | 0.1563 |
5366 | PMAIP1 | GSM4909320 | Human | Breast | IDC | 4.22e-03 | -4.29e-01 | 0.1575 |
5366 | PMAIP1 | GSM4909321 | Human | Breast | IDC | 9.42e-04 | -4.56e-02 | 0.1559 |
5366 | PMAIP1 | NCCBC14 | Human | Breast | DCIS | 1.32e-06 | -3.82e-01 | 0.2021 |
5366 | PMAIP1 | NCCBC3 | Human | Breast | DCIS | 2.85e-12 | -4.19e-01 | 0.1198 |
5366 | PMAIP1 | NCCBC5 | Human | Breast | DCIS | 9.09e-05 | -1.48e-01 | 0.2046 |
5366 | PMAIP1 | P1 | Human | Breast | IDC | 1.23e-10 | -3.25e-01 | 0.1527 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005188117 | Skin | AK | regulation of mitochondrial membrane potential | 18/1910 | 74/18723 | 3.61e-04 | 3.58e-03 | 18 |
GO:003166727 | Skin | AK | response to nutrient levels | 72/1910 | 474/18723 | 3.74e-04 | 3.63e-03 | 72 |
GO:003166924 | Skin | AK | cellular response to nutrient levels | 38/1910 | 215/18723 | 5.37e-04 | 4.86e-03 | 38 |
GO:001082120 | Skin | AK | regulation of mitochondrion organization | 28/1910 | 144/18723 | 6.05e-04 | 5.32e-03 | 28 |
GO:000683926 | Skin | AK | mitochondrial transport | 43/1910 | 254/18723 | 6.18e-04 | 5.42e-03 | 43 |
GO:00433311 | Skin | AK | response to dsRNA | 14/1910 | 55/18723 | 9.79e-04 | 7.78e-03 | 14 |
GO:003629325 | Skin | AK | response to decreased oxygen levels | 51/1910 | 322/18723 | 9.99e-04 | 7.88e-03 | 51 |
GO:000166625 | Skin | AK | response to hypoxia | 49/1910 | 307/18723 | 1.05e-03 | 8.20e-03 | 49 |
GO:000862520 | Skin | AK | extrinsic apoptotic signaling pathway via death domain receptors | 18/1910 | 82/18723 | 1.32e-03 | 9.92e-03 | 18 |
GO:00435169 | Skin | AK | regulation of DNA damage response, signal transduction by p53 class mediator | 10/1910 | 34/18723 | 1.57e-03 | 1.13e-02 | 10 |
GO:007048225 | Skin | AK | response to oxygen levels | 53/1910 | 347/18723 | 1.84e-03 | 1.27e-02 | 53 |
GO:009055910 | Skin | AK | regulation of membrane permeability | 17/1910 | 78/18723 | 1.93e-03 | 1.31e-02 | 17 |
GO:19058986 | Skin | AK | positive regulation of response to endoplasmic reticulum stress | 10/1910 | 35/18723 | 2.00e-03 | 1.35e-02 | 10 |
GO:000926720 | Skin | AK | cellular response to starvation | 28/1910 | 156/18723 | 2.15e-03 | 1.43e-02 | 28 |
GO:004259420 | Skin | AK | response to starvation | 32/1910 | 197/18723 | 5.47e-03 | 3.02e-02 | 32 |
GO:004328024 | Skin | AK | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 23/1910 | 129/18723 | 5.54e-03 | 3.05e-02 | 23 |
GO:000183620 | Skin | AK | release of cytochrome c from mitochondria | 13/1910 | 59/18723 | 5.70e-03 | 3.12e-02 | 13 |
GO:003629420 | Skin | AK | cellular response to decreased oxygen levels | 27/1910 | 161/18723 | 6.64e-03 | 3.50e-02 | 27 |
GO:007145320 | Skin | AK | cellular response to oxygen levels | 29/1910 | 177/18723 | 7.00e-03 | 3.63e-02 | 29 |
GO:00109174 | Skin | AK | negative regulation of mitochondrial membrane potential | 5/1910 | 13/18723 | 7.01e-03 | 3.63e-02 | 5 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa042108 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa052036 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0421013 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa0520312 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0421022 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0520322 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa041157 | Breast | IDC | p53 signaling pathway | 16/867 | 74/8465 | 2.86e-03 | 1.86e-02 | 1.39e-02 | 16 |
hsa052109 | Breast | IDC | Colorectal cancer | 17/867 | 86/8465 | 5.70e-03 | 3.13e-02 | 2.34e-02 | 17 |
hsa0421032 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0520332 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0411512 | Breast | IDC | p53 signaling pathway | 16/867 | 74/8465 | 2.86e-03 | 1.86e-02 | 1.39e-02 | 16 |
hsa0521014 | Breast | IDC | Colorectal cancer | 17/867 | 86/8465 | 5.70e-03 | 3.13e-02 | 2.34e-02 | 17 |
hsa0421041 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
hsa0520341 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa0411521 | Breast | DCIS | p53 signaling pathway | 16/846 | 74/8465 | 2.23e-03 | 1.47e-02 | 1.08e-02 | 16 |
hsa0521024 | Breast | DCIS | Colorectal cancer | 16/846 | 86/8465 | 1.03e-02 | 4.50e-02 | 3.32e-02 | 16 |
hsa0421051 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
hsa052035 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa0411531 | Breast | DCIS | p53 signaling pathway | 16/846 | 74/8465 | 2.23e-03 | 1.47e-02 | 1.08e-02 | 16 |
hsa0521034 | Breast | DCIS | Colorectal cancer | 16/846 | 86/8465 | 1.03e-02 | 4.50e-02 | 3.32e-02 | 16 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PMAIP1 | SNV | Missense_Mutation | novel | c.4C>T | p.Pro2Ser | p.P2S | Q13794 | protein_coding | deleterious(0.01) | possibly_damaging(0.561) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
PMAIP1 | SNV | Missense_Mutation | novel | c.97G>A | p.Gly33Arg | p.G33R | Q13794 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-7383-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5366 | PMAIP1 | CLINICALLY ACTIONABLE | BORTEZOMIB | BORTEZOMIB | 16024631 |
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