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Gene: KHDRBS1 |
Gene summary for KHDRBS1 |
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Gene information | Species | Human | Gene symbol | KHDRBS1 | Gene ID | 10657 |
Gene name | KH RNA binding domain containing, signal transduction associated 1 | |
Gene Alias | Sam68 | |
Cytomap | 1p35.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q07666 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10657 | KHDRBS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.42e-04 | 5.69e-01 | -0.0811 |
10657 | KHDRBS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.06e-02 | 4.86e-01 | -0.1088 |
10657 | KHDRBS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.61e-14 | 7.14e-01 | -0.1954 |
10657 | KHDRBS1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.35e-05 | 7.00e-01 | -0.059 |
10657 | KHDRBS1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.84e-03 | 5.09e-01 | 0.0674 |
10657 | KHDRBS1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.78e-12 | 7.09e-01 | 0.294 |
10657 | KHDRBS1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 7.94e-11 | 1.40e+00 | 0.3487 |
10657 | KHDRBS1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.55e-11 | 8.39e-01 | 0.281 |
10657 | KHDRBS1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.89e-03 | 6.76e-01 | 0.3859 |
10657 | KHDRBS1 | F007 | Human | Colorectum | FAP | 7.65e-04 | -3.64e-01 | 0.1176 |
10657 | KHDRBS1 | A001-C-207 | Human | Colorectum | FAP | 1.38e-02 | -2.73e-01 | 0.1278 |
10657 | KHDRBS1 | A015-C-203 | Human | Colorectum | FAP | 1.19e-26 | -4.43e-01 | -0.1294 |
10657 | KHDRBS1 | A015-C-204 | Human | Colorectum | FAP | 3.84e-05 | -2.84e-01 | -0.0228 |
10657 | KHDRBS1 | A014-C-040 | Human | Colorectum | FAP | 2.15e-04 | -4.96e-01 | -0.1184 |
10657 | KHDRBS1 | A002-C-201 | Human | Colorectum | FAP | 1.10e-08 | -2.28e-01 | 0.0324 |
10657 | KHDRBS1 | A002-C-203 | Human | Colorectum | FAP | 6.29e-04 | -1.81e-01 | 0.2786 |
10657 | KHDRBS1 | A001-C-119 | Human | Colorectum | FAP | 1.07e-02 | -2.34e-01 | -0.1557 |
10657 | KHDRBS1 | A001-C-108 | Human | Colorectum | FAP | 1.04e-14 | -2.81e-01 | -0.0272 |
10657 | KHDRBS1 | A002-C-205 | Human | Colorectum | FAP | 1.33e-18 | -3.89e-01 | -0.1236 |
10657 | KHDRBS1 | A015-C-005 | Human | Colorectum | FAP | 5.07e-03 | -2.75e-01 | -0.0336 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004483911 | Skin | cSCC | cell cycle G2/M phase transition | 61/4864 | 148/18723 | 3.61e-05 | 3.90e-04 | 61 |
GO:00459484 | Skin | cSCC | positive regulation of translational initiation | 18/4864 | 30/18723 | 8.53e-05 | 8.08e-04 | 18 |
GO:004683114 | Skin | cSCC | regulation of RNA export from nucleus | 8/4864 | 12/18723 | 3.61e-03 | 1.94e-02 | 8 |
GO:005085221 | Skin | cSCC | T cell receptor signaling pathway | 44/4864 | 123/18723 | 1.02e-02 | 4.47e-02 | 44 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:0000375113 | Thyroid | PTC | RNA splicing, via transesterification reactions | 202/5968 | 324/18723 | 6.81e-30 | 3.91e-27 | 202 |
GO:0000377113 | Thyroid | PTC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:0000398113 | Thyroid | PTC | mRNA splicing, via spliceosome | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:1903311112 | Thyroid | PTC | regulation of mRNA metabolic process | 181/5968 | 288/18723 | 1.60e-27 | 5.94e-25 | 181 |
GO:0032386111 | Thyroid | PTC | regulation of intracellular transport | 202/5968 | 337/18723 | 1.12e-26 | 3.93e-24 | 202 |
GO:0006913112 | Thyroid | PTC | nucleocytoplasmic transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
GO:0051169112 | Thyroid | PTC | nuclear transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
GO:0032388112 | Thyroid | PTC | positive regulation of intracellular transport | 132/5968 | 202/18723 | 1.10e-22 | 2.57e-20 | 132 |
GO:0006403112 | Thyroid | PTC | RNA localization | 130/5968 | 201/18723 | 9.23e-22 | 1.94e-19 | 130 |
GO:0050684112 | Thyroid | PTC | regulation of mRNA processing | 98/5968 | 137/18723 | 1.53e-21 | 3.10e-19 | 98 |
GO:0043484113 | Thyroid | PTC | regulation of RNA splicing | 102/5968 | 148/18723 | 2.03e-20 | 3.21e-18 | 102 |
GO:0051168112 | Thyroid | PTC | nuclear export | 102/5968 | 154/18723 | 1.78e-18 | 2.01e-16 | 102 |
GO:0006413112 | Thyroid | PTC | translational initiation | 84/5968 | 118/18723 | 1.89e-18 | 2.09e-16 | 84 |
GO:0006417113 | Thyroid | PTC | regulation of translation | 236/5968 | 468/18723 | 2.70e-17 | 2.52e-15 | 236 |
GO:004682223 | Thyroid | PTC | regulation of nucleocytoplasmic transport | 76/5968 | 106/18723 | 4.11e-17 | 3.70e-15 | 76 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KHDRBS1 | SNV | Missense_Mutation | novel | c.845N>A | p.Arg282His | p.R282H | Q07666 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
KHDRBS1 | SNV | Missense_Mutation | novel | c.308N>G | p.Tyr103Cys | p.Y103C | Q07666 | protein_coding | tolerated(0.05) | probably_damaging(0.981) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KHDRBS1 | SNV | Missense_Mutation | c.1106N>G | p.Tyr369Cys | p.Y369C | Q07666 | protein_coding | deleterious(0.02) | benign(0.322) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KHDRBS1 | SNV | Missense_Mutation | c.637N>T | p.Arg213Cys | p.R213C | Q07666 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
KHDRBS1 | SNV | Missense_Mutation | c.538N>A | p.Gln180Lys | p.Q180K | Q07666 | protein_coding | tolerated(0.76) | benign(0.127) | TCGA-AD-6548-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KHDRBS1 | SNV | Missense_Mutation | novel | c.854G>A | p.Gly285Glu | p.G285E | Q07666 | protein_coding | deleterious(0.03) | benign(0.131) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KHDRBS1 | insertion | Frame_Shift_Ins | novel | c.261_262insC | p.Ser90LeufsTer41 | p.S90Lfs*41 | Q07666 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | ||
KHDRBS1 | insertion | Frame_Shift_Ins | novel | c.934dupG | p.Ala312GlyfsTer56 | p.A312Gfs*56 | Q07666 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
KHDRBS1 | SNV | Missense_Mutation | novel | c.1049N>T | p.Ala350Val | p.A350V | Q07666 | protein_coding | deleterious(0.03) | benign(0.105) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KHDRBS1 | SNV | Missense_Mutation | novel | c.871C>T | p.Arg291Trp | p.R291W | Q07666 | protein_coding | deleterious(0.04) | benign(0.019) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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