Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: EIF5

Gene summary for EIF5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

EIF5

Gene ID

1983

Gene nameeukaryotic translation initiation factor 5
Gene AliasEIF-5
Cytomap14q32.32
Gene Typeprotein-coding
GO ID

GO:0001731

UniProtAcc

A0A024R6Q1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1983EIF5GSM4909277HumanBreastPrecancer1.37e-055.06e-010.0177
1983EIF5GSM4909285HumanBreastIDC3.38e-03-2.66e-010.21
1983EIF5GSM4909286HumanBreastIDC1.62e-05-2.41e-010.1081
1983EIF5GSM4909287HumanBreastIDC1.16e-03-4.08e-010.2057
1983EIF5GSM4909293HumanBreastIDC1.17e-03-3.32e-010.1581
1983EIF5GSM4909294HumanBreastIDC1.79e-04-3.68e-010.2022
1983EIF5GSM4909296HumanBreastIDC7.00e-10-3.77e-010.1524
1983EIF5GSM4909297HumanBreastIDC1.79e-15-3.42e-010.1517
1983EIF5GSM4909301HumanBreastIDC1.59e-03-3.70e-010.1577
1983EIF5GSM4909302HumanBreastIDC4.19e-11-5.55e-010.1545
1983EIF5GSM4909311HumanBreastIDC6.26e-37-6.88e-010.1534
1983EIF5GSM4909312HumanBreastIDC5.68e-15-4.79e-010.1552
1983EIF5GSM4909313HumanBreastIDC1.26e-06-4.69e-010.0391
1983EIF5GSM4909319HumanBreastIDC6.07e-43-6.40e-010.1563
1983EIF5GSM4909320HumanBreastIDC3.52e-04-3.47e-010.1575
1983EIF5GSM4909321HumanBreastIDC2.92e-11-2.65e-010.1559
1983EIF5brca1HumanBreastPrecancer1.15e-144.19e-01-0.0338
1983EIF5brca10HumanBreastPrecancer6.85e-05-4.55e-01-0.0029
1983EIF5NCCBC14HumanBreastDCIS2.66e-07-1.32e-010.2021
1983EIF5NCCBC5HumanBreastDCIS1.01e-11-3.84e-010.2046
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003461231Oral cavityNEOLPresponse to tumor necrosis factor55/2005253/187232.23e-077.28e-0655
GO:200123532Oral cavityNEOLPpositive regulation of apoptotic signaling pathway34/2005126/187232.55e-078.23e-0634
GO:005065731Oral cavityNEOLPnucleic acid transport40/2005163/187233.74e-071.15e-0540
GO:005065831Oral cavityNEOLPRNA transport40/2005163/187233.74e-071.15e-0540
GO:000644631Oral cavityNEOLPregulation of translational initiation25/200579/187233.75e-071.15e-0525
GO:004572732Oral cavityNEOLPpositive regulation of translation35/2005136/187235.91e-071.74e-0535
GO:005123631Oral cavityNEOLPestablishment of RNA localization40/2005166/187236.24e-071.82e-0540
GO:007135631Oral cavityNEOLPcellular response to tumor necrosis factor50/2005229/187236.79e-071.93e-0550
GO:000173232Oral cavityNEOLPformation of cytoplasmic translation initiation complex10/200516/187238.46e-072.30e-0510
GO:003425033Oral cavityNEOLPpositive regulation of cellular amide metabolic process39/2005162/187238.79e-072.37e-0539
GO:001593131Oral cavityNEOLPnucleobase-containing compound transport48/2005222/187231.51e-063.77e-0548
GO:003320931Oral cavityNEOLPtumor necrosis factor-mediated signaling pathway27/200599/187233.40e-067.60e-0527
GO:007233134Oral cavityNEOLPsignal transduction by p53 class mediator37/2005163/187237.22e-061.43e-0437
GO:005102831Oral cavityNEOLPmRNA transport31/2005130/187231.38e-052.43e-0431
GO:190225331Oral cavityNEOLPregulation of intrinsic apoptotic signaling pathway by p53 class mediator12/200529/187231.99e-053.32e-0412
GO:190179833Oral cavityNEOLPpositive regulation of signal transduction by p53 class mediator11/200525/187232.21e-053.60e-0411
GO:004324421Oral cavityNEOLPregulation of protein-containing complex disassembly29/2005121/187232.33e-053.72e-0429
GO:003298431Oral cavityNEOLPprotein-containing complex disassembly45/2005224/187232.33e-053.72e-0445
GO:190179634Oral cavityNEOLPregulation of signal transduction by p53 class mediator24/200593/187233.18e-054.80e-0424
GO:007233232Oral cavityNEOLPintrinsic apoptotic signaling pathway by p53 class mediator21/200576/187233.26e-054.86e-0421
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
EIF5SNVMissense_Mutationc.39C>Gp.Phe13Leup.F13LP55010protein_codingdeleterious(0.03)possibly_damaging(0.558)TCGA-A2-A0YL-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
EIF5SNVMissense_Mutationc.238C>Tp.His80Tyrp.H80YP55010protein_codingdeleterious(0)benign(0.277)TCGA-A2-A0YL-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
EIF5SNVMissense_Mutationrs779336285c.124G>Ap.Val42Ilep.V42IP55010protein_codingtolerated(0.55)benign(0.013)TCGA-D8-A1JD-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
EIF5SNVMissense_Mutationc.33N>Gp.Asp11Glup.D11EP55010protein_codingdeleterious(0)possibly_damaging(0.87)TCGA-E2-A14O-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyarimidexSD
EIF5insertionIn_Frame_Insnovelc.321_322insTGTCTTGCAGCTTATTCGCCTCATp.Thr107_Asp108insCysLeuAlaAlaTyrSerProHisp.T107_D108insCLAAYSPHP55010protein_codingTCGA-A7-A0CE-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
EIF5insertionNonsense_Mutationnovelc.507_508insCGAGGTCAGGAGTTCTAGACCAGCCTAGCCAACATp.Asn170ArgfsTer6p.N170Rfs*6P55010protein_codingTCGA-A8-A09W-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
EIF5insertionNonsense_Mutationnovelc.311_312insCGTCTGATTGCCAAGGTAATAAACTGCTCTTCAATTTAGTp.Pro105ValfsTer2p.P105Vfs*2P55010protein_codingTCGA-A8-A09X-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
EIF5SNVMissense_Mutationnovelc.1204N>Ap.Glu402Lysp.E402KP55010protein_codingdeleterious(0.02)benign(0.173)TCGA-C5-A1MN-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinSD
EIF5SNVMissense_Mutationnovelc.89N>Gp.Asn30Serp.N30SP55010protein_codingdeleterious(0)probably_damaging(0.946)TCGA-MA-AA3Z-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
EIF5SNVMissense_Mutationnovelc.173N>Tp.Gly58Valp.G58VP55010protein_codingdeleterious(0)benign(0.267)TCGA-VS-A9V5-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycarboplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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