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Gene: DDX3X |
Gene summary for DDX3X |
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Gene information | Species | Human | Gene symbol | DDX3X | Gene ID | 1654 |
Gene name | DEAD-box helicase 3 X-linked | |
Gene Alias | CAP-Rf | |
Cytomap | Xp11.4 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O00571 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1654 | DDX3X | GSM4909282 | Human | Breast | IDC | 1.60e-08 | -4.66e-01 | -0.0288 |
1654 | DDX3X | GSM4909285 | Human | Breast | IDC | 2.26e-03 | -3.03e-01 | 0.21 |
1654 | DDX3X | GSM4909286 | Human | Breast | IDC | 1.38e-07 | -2.68e-01 | 0.1081 |
1654 | DDX3X | GSM4909293 | Human | Breast | IDC | 7.56e-05 | 2.20e-01 | 0.1581 |
1654 | DDX3X | GSM4909294 | Human | Breast | IDC | 3.00e-05 | -2.81e-01 | 0.2022 |
1654 | DDX3X | GSM4909296 | Human | Breast | IDC | 1.49e-15 | -4.01e-01 | 0.1524 |
1654 | DDX3X | GSM4909297 | Human | Breast | IDC | 1.39e-14 | -1.92e-01 | 0.1517 |
1654 | DDX3X | GSM4909301 | Human | Breast | IDC | 1.01e-02 | -3.16e-01 | 0.1577 |
1654 | DDX3X | GSM4909311 | Human | Breast | IDC | 5.10e-37 | -5.06e-01 | 0.1534 |
1654 | DDX3X | GSM4909312 | Human | Breast | IDC | 9.85e-13 | -2.67e-01 | 0.1552 |
1654 | DDX3X | GSM4909313 | Human | Breast | IDC | 1.09e-04 | 1.49e-01 | 0.0391 |
1654 | DDX3X | GSM4909317 | Human | Breast | IDC | 4.79e-07 | 3.61e-01 | 0.1355 |
1654 | DDX3X | GSM4909319 | Human | Breast | IDC | 8.78e-39 | -6.57e-01 | 0.1563 |
1654 | DDX3X | GSM4909320 | Human | Breast | IDC | 1.57e-05 | -5.09e-01 | 0.1575 |
1654 | DDX3X | GSM4909321 | Human | Breast | IDC | 1.04e-15 | -2.05e-01 | 0.1559 |
1654 | DDX3X | brca1 | Human | Breast | Precancer | 6.61e-04 | -3.33e-01 | -0.0338 |
1654 | DDX3X | brca10 | Human | Breast | Precancer | 4.37e-07 | -4.79e-01 | -0.0029 |
1654 | DDX3X | NCCBC14 | Human | Breast | DCIS | 3.00e-06 | -1.85e-01 | 0.2021 |
1654 | DDX3X | NCCBC5 | Human | Breast | DCIS | 5.30e-12 | -3.22e-01 | 0.2046 |
1654 | DDX3X | P1 | Human | Breast | IDC | 1.12e-23 | 2.15e-02 | 0.1527 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00705342 | Liver | Cirrhotic | protein K63-linked ubiquitination | 22/4634 | 56/18723 | 1.14e-02 | 4.96e-02 | 22 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
GO:003497612 | Liver | HCC | response to endoplasmic reticulum stress | 189/7958 | 256/18723 | 1.43e-24 | 4.06e-22 | 189 |
GO:001905822 | Liver | HCC | viral life cycle | 209/7958 | 317/18723 | 2.05e-17 | 2.09e-15 | 209 |
GO:190332022 | Liver | HCC | regulation of protein modification by small protein conjugation or removal | 167/7958 | 242/18723 | 4.99e-17 | 4.72e-15 | 167 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:000641322 | Liver | HCC | translational initiation | 94/7958 | 118/18723 | 1.39e-16 | 1.24e-14 | 94 |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
GO:004586222 | Liver | HCC | positive regulation of proteolysis | 232/7958 | 372/18723 | 5.66e-15 | 3.98e-13 | 232 |
GO:003139622 | Liver | HCC | regulation of protein ubiquitination | 142/7958 | 210/18723 | 1.39e-13 | 7.81e-12 | 142 |
GO:009719322 | Liver | HCC | intrinsic apoptotic signaling pathway | 184/7958 | 288/18723 | 1.50e-13 | 8.32e-12 | 184 |
GO:00064732 | Liver | HCC | protein acetylation | 135/7958 | 201/18723 | 1.20e-12 | 5.92e-11 | 135 |
GO:00435432 | Liver | HCC | protein acylation | 157/7958 | 243/18723 | 2.40e-12 | 1.12e-10 | 157 |
GO:009719122 | Liver | HCC | extrinsic apoptotic signaling pathway | 143/7958 | 219/18723 | 6.99e-12 | 2.97e-10 | 143 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052036 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0520312 | Breast | Precancer | Viral carcinogenesis | 27/684 | 204/8465 | 7.19e-03 | 4.06e-02 | 3.11e-02 | 27 |
hsa0520322 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0520332 | Breast | IDC | Viral carcinogenesis | 34/867 | 204/8465 | 2.82e-03 | 1.86e-02 | 1.39e-02 | 34 |
hsa0520341 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa052035 | Breast | DCIS | Viral carcinogenesis | 34/846 | 204/8465 | 1.88e-03 | 1.27e-02 | 9.33e-03 | 34 |
hsa052039 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0520315 | Esophagus | HGIN | Viral carcinogenesis | 53/1383 | 204/8465 | 2.58e-04 | 2.71e-03 | 2.15e-03 | 53 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa051619 | Esophagus | ESCC | Hepatitis B | 108/4205 | 162/8465 | 7.68e-06 | 4.15e-05 | 2.12e-05 | 108 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0516114 | Esophagus | ESCC | Hepatitis B | 108/4205 | 162/8465 | 7.68e-06 | 4.15e-05 | 2.12e-05 | 108 |
hsa05203 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa052031 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa051612 | Liver | HCC | Hepatitis B | 91/4020 | 162/8465 | 1.56e-02 | 3.76e-02 | 2.09e-02 | 91 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa0516111 | Liver | HCC | Hepatitis B | 91/4020 | 162/8465 | 1.56e-02 | 3.76e-02 | 2.09e-02 | 91 |
hsa051618 | Oral cavity | OSCC | Hepatitis B | 103/3704 | 162/8465 | 2.34e-07 | 1.51e-06 | 7.69e-07 | 103 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX3X | SNV | Missense_Mutation | c.1675N>A | p.Leu559Ile | p.L559I | O00571 | protein_coding | tolerated(0.31) | benign(0.182) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DDX3X | SNV | Missense_Mutation | novel | c.878C>A | p.Ser293Tyr | p.S293Y | O00571 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DDX3X | SNV | Missense_Mutation | c.425N>T | p.Pro142Leu | p.P142L | O00571 | protein_coding | tolerated(0.11) | benign(0.179) | TCGA-AO-A03L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
DDX3X | SNV | Missense_Mutation | novel | c.536N>C | p.Ile179Thr | p.I179T | O00571 | protein_coding | deleterious(0.03) | benign(0.336) | TCGA-B6-A402-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PD |
DDX3X | SNV | Missense_Mutation | c.203C>T | p.Ala68Val | p.A68V | O00571 | protein_coding | tolerated(0.15) | benign(0) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
DDX3X | SNV | Missense_Mutation | c.1907N>A | p.Gly636Glu | p.G636E | O00571 | protein_coding | tolerated(0.09) | probably_damaging(0.994) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DDX3X | SNV | Missense_Mutation | c.81N>C | p.Gln27His | p.Q27H | O00571 | protein_coding | deleterious(0.04) | possibly_damaging(0.462) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
DDX3X | SNV | Missense_Mutation | novel | c.1321G>C | p.Asp441His | p.D441H | O00571 | protein_coding | deleterious(0.02) | possibly_damaging(0.749) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
DDX3X | SNV | Missense_Mutation | novel | c.1873N>A | p.Gly625Arg | p.G625R | O00571 | protein_coding | deleterious(0.04) | benign(0.009) | TCGA-E2-A1B0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
DDX3X | SNV | Missense_Mutation | novel | c.577N>A | p.Gly193Arg | p.G193R | O00571 | protein_coding | tolerated(0.4) | benign(0.272) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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