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Gene: DDX39B |
Gene summary for DDX39B |
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Gene information | Species | Human | Gene symbol | DDX39B | Gene ID | 7919 |
Gene name | DExD-box helicase 39B | |
Gene Alias | BAT1 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | A0A024RCM3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7919 | DDX39B | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.05e-23 | 4.15e-01 | 0.0155 |
7919 | DDX39B | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.82e-20 | 5.88e-01 | -0.1808 |
7919 | DDX39B | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.84e-10 | 5.85e-01 | 0.0216 |
7919 | DDX39B | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.76e-31 | 7.71e-01 | -0.0811 |
7919 | DDX39B | HTA11_78_2000001011 | Human | Colorectum | AD | 3.57e-32 | 6.94e-01 | -0.1088 |
7919 | DDX39B | HTA11_347_2000001011 | Human | Colorectum | AD | 3.89e-58 | 9.40e-01 | -0.1954 |
7919 | DDX39B | HTA11_411_2000001011 | Human | Colorectum | SER | 6.89e-14 | 9.53e-01 | -0.2602 |
7919 | DDX39B | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.90e-09 | 5.59e-01 | -0.2196 |
7919 | DDX39B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.96e-16 | 5.89e-01 | -0.1207 |
7919 | DDX39B | HTA11_83_2000001011 | Human | Colorectum | SER | 2.91e-27 | 7.43e-01 | -0.1526 |
7919 | DDX39B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.66e-48 | 7.71e-01 | -0.1464 |
7919 | DDX39B | HTA11_866_2000001011 | Human | Colorectum | AD | 1.68e-40 | 7.09e-01 | -0.1001 |
7919 | DDX39B | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.17e-42 | 1.01e+00 | -0.059 |
7919 | DDX39B | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.50e-12 | 5.66e-01 | -0.1706 |
7919 | DDX39B | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.91e-11 | 4.78e-01 | -0.2061 |
7919 | DDX39B | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.17e-09 | 4.66e-01 | -0.1462 |
7919 | DDX39B | HTA11_546_2000001011 | Human | Colorectum | AD | 2.07e-24 | 8.00e-01 | -0.0842 |
7919 | DDX39B | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.27e-11 | 4.04e-01 | -0.0179 |
7919 | DDX39B | HTA11_866_3004761011 | Human | Colorectum | AD | 1.47e-27 | 6.15e-01 | 0.096 |
7919 | DDX39B | HTA11_4255_2000001011 | Human | Colorectum | SER | 6.82e-15 | 6.95e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226136 | Stomach | GC | ribonucleoprotein complex biogenesis | 49/1159 | 463/18723 | 1.72e-04 | 3.02e-03 | 49 |
GO:20002786 | Stomach | GC | regulation of DNA biosynthetic process | 15/1159 | 106/18723 | 2.21e-03 | 2.18e-02 | 15 |
GO:00511686 | Stomach | GC | nuclear export | 19/1159 | 154/18723 | 3.14e-03 | 2.79e-02 | 19 |
GO:00064176 | Stomach | GC | regulation of translation | 44/1159 | 468/18723 | 3.81e-03 | 3.22e-02 | 44 |
GO:004440311 | Stomach | CAG with IM | biological process involved in symbiotic interaction | 36/1050 | 290/18723 | 6.58e-06 | 2.40e-04 | 36 |
GO:004572711 | Stomach | CAG with IM | positive regulation of translation | 22/1050 | 136/18723 | 6.73e-06 | 2.42e-04 | 22 |
GO:007182611 | Stomach | CAG with IM | ribonucleoprotein complex subunit organization | 30/1050 | 227/18723 | 1.12e-05 | 3.70e-04 | 30 |
GO:002261311 | Stomach | CAG with IM | ribonucleoprotein complex biogenesis | 49/1050 | 463/18723 | 1.47e-05 | 4.77e-04 | 49 |
GO:002261811 | Stomach | CAG with IM | ribonucleoprotein complex assembly | 29/1050 | 220/18723 | 1.64e-05 | 5.16e-04 | 29 |
GO:003425011 | Stomach | CAG with IM | positive regulation of cellular amide metabolic process | 23/1050 | 162/18723 | 3.71e-05 | 1.02e-03 | 23 |
GO:005170111 | Stomach | CAG with IM | biological process involved in interaction with host | 26/1050 | 203/18723 | 7.20e-05 | 1.74e-03 | 26 |
GO:004873211 | Stomach | CAG with IM | gland development | 44/1050 | 436/18723 | 1.20e-04 | 2.54e-03 | 44 |
GO:000188911 | Stomach | CAG with IM | liver development | 19/1050 | 147/18723 | 5.76e-04 | 8.41e-03 | 19 |
GO:006100811 | Stomach | CAG with IM | hepaticobiliary system development | 19/1050 | 150/18723 | 7.41e-04 | 1.01e-02 | 19 |
GO:200027811 | Stomach | CAG with IM | regulation of DNA biosynthetic process | 15/1050 | 106/18723 | 8.29e-04 | 1.09e-02 | 15 |
GO:005116811 | Stomach | CAG with IM | nuclear export | 19/1050 | 154/18723 | 1.02e-03 | 1.29e-02 | 19 |
GO:000641711 | Stomach | CAG with IM | regulation of translation | 43/1050 | 468/18723 | 1.03e-03 | 1.29e-02 | 43 |
GO:00083806 | Stomach | CAG with IM | RNA splicing | 39/1050 | 434/18723 | 2.55e-03 | 2.49e-02 | 39 |
GO:20005736 | Stomach | CAG with IM | positive regulation of DNA biosynthetic process | 10/1050 | 66/18723 | 3.55e-03 | 3.17e-02 | 10 |
GO:0042770 | Stomach | CAG with IM | signal transduction in response to DNA damage | 19/1050 | 172/18723 | 3.68e-03 | 3.27e-02 | 19 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03015 | Colorectum | AD | mRNA surveillance pathway | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa030151 | Colorectum | AD | mRNA surveillance pathway | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa030159 | Esophagus | HGIN | mRNA surveillance pathway | 30/1383 | 97/8465 | 2.48e-04 | 2.69e-03 | 2.14e-03 | 30 |
hsa030137 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa0304019 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
hsa0301514 | Esophagus | HGIN | mRNA surveillance pathway | 30/1383 | 97/8465 | 2.48e-04 | 2.69e-03 | 2.14e-03 | 30 |
hsa0301312 | Esophagus | HGIN | Nucleocytoplasmic transport | 31/1383 | 108/8465 | 8.29e-04 | 7.95e-03 | 6.31e-03 | 31 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301524 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301534 | Esophagus | ESCC | mRNA surveillance pathway | 72/4205 | 97/8465 | 6.12e-07 | 4.10e-06 | 2.10e-06 | 72 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304010 | Prostate | BPH | Spliceosome | 62/1718 | 217/8465 | 1.99e-03 | 7.92e-03 | 4.90e-03 | 62 |
hsa030155 | Prostate | BPH | mRNA surveillance pathway | 32/1718 | 97/8465 | 2.20e-03 | 8.63e-03 | 5.34e-03 | 32 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DDX39B | SNV | Missense_Mutation | novel | c.1126G>T | p.Ala376Ser | p.A376S | Q13838 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
DDX39B | SNV | Missense_Mutation | c.1013N>A | p.Arg338Gln | p.R338Q | Q13838 | protein_coding | tolerated(0.09) | benign(0.011) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
DDX39B | SNV | Missense_Mutation | novel | c.599N>C | p.Lys200Thr | p.K200T | Q13838 | protein_coding | deleterious(0.03) | possibly_damaging(0.885) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DDX39B | deletion | Frame_Shift_Del | c.447delT | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
DDX39B | deletion | Frame_Shift_Del | c.447delN | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DDX39B | deletion | Frame_Shift_Del | c.447delT | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
DDX39B | deletion | Frame_Shift_Del | c.447delN | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |||
DDX39B | deletion | Frame_Shift_Del | c.447delT | p.Phe149LeufsTer13 | p.F149Lfs*13 | Q13838 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |||
DDX39B | deletion | In_Frame_Del | novel | c.814_816delNNN | p.Asn272del | p.N272del | Q13838 | protein_coding | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
DDX39B | SNV | Missense_Mutation | novel | c.1139N>A | p.Arg380Gln | p.R380Q | Q13838 | protein_coding | deleterious(0.01) | possibly_damaging(0.55) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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