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Gene: WWTR1 |
Gene summary for WWTR1 |
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Gene information | Species | Human | Gene symbol | WWTR1 | Gene ID | 25937 |
Gene name | WW domain containing transcription regulator 1 | |
Gene Alias | TAZ | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9GZV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25937 | WWTR1 | CA_HPV_3 | Human | Cervix | CC | 2.68e-03 | 1.21e-01 | 0.0414 |
25937 | WWTR1 | CCI_1 | Human | Cervix | CC | 2.45e-02 | 7.22e-01 | 0.528 |
25937 | WWTR1 | CCI_2 | Human | Cervix | CC | 2.19e-16 | 1.85e+00 | 0.5249 |
25937 | WWTR1 | CCI_3 | Human | Cervix | CC | 1.52e-13 | 9.59e-01 | 0.516 |
25937 | WWTR1 | T1 | Human | Cervix | CC | 3.93e-10 | 4.51e-01 | 0.0918 |
25937 | WWTR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.21e-05 | 2.92e-01 | -0.0811 |
25937 | WWTR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.23e-10 | 3.10e-01 | -0.1954 |
25937 | WWTR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.27e-02 | 5.72e-01 | -0.2602 |
25937 | WWTR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.49e-08 | 3.78e-01 | -0.059 |
25937 | WWTR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.25e-02 | 2.64e-01 | -0.0179 |
25937 | WWTR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.18e-05 | 3.62e-01 | 0.096 |
25937 | WWTR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.50e-21 | 5.46e-01 | 0.294 |
25937 | WWTR1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 9.49e-08 | 9.05e-01 | 0.3487 |
25937 | WWTR1 | A001-C-119 | Human | Colorectum | FAP | 6.01e-04 | 4.34e-01 | -0.1557 |
25937 | WWTR1 | AEH-subject1 | Human | Endometrium | AEH | 1.24e-07 | 3.40e-01 | -0.3059 |
25937 | WWTR1 | AEH-subject2 | Human | Endometrium | AEH | 5.66e-08 | 2.41e-01 | -0.2525 |
25937 | WWTR1 | AEH-subject3 | Human | Endometrium | AEH | 1.33e-07 | 9.98e-02 | -0.2576 |
25937 | WWTR1 | AEH-subject4 | Human | Endometrium | AEH | 2.00e-08 | 3.56e-01 | -0.2657 |
25937 | WWTR1 | AEH-subject5 | Human | Endometrium | AEH | 1.96e-33 | 8.33e-01 | -0.2953 |
25937 | WWTR1 | EEC-subject1 | Human | Endometrium | EEC | 2.73e-26 | 6.79e-01 | -0.2682 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00107171 | Prostate | Tumor | regulation of epithelial to mesenchymal transition | 31/3246 | 99/18723 | 4.74e-04 | 3.54e-03 | 31 |
GO:007200113 | Prostate | Tumor | renal system development | 75/3246 | 302/18723 | 5.74e-04 | 4.13e-03 | 75 |
GO:007216013 | Prostate | Tumor | nephron tubule epithelial cell differentiation | 8/3246 | 14/18723 | 8.99e-04 | 5.96e-03 | 8 |
GO:004566911 | Prostate | Tumor | positive regulation of osteoblast differentiation | 23/3246 | 69/18723 | 9.47e-04 | 6.20e-03 | 23 |
GO:003017813 | Prostate | Tumor | negative regulation of Wnt signaling pathway | 46/3246 | 170/18723 | 9.84e-04 | 6.37e-03 | 46 |
GO:004559811 | Prostate | Tumor | regulation of fat cell differentiation | 39/3246 | 139/18723 | 1.11e-03 | 7.12e-03 | 39 |
GO:009009012 | Prostate | Tumor | negative regulation of canonical Wnt signaling pathway | 38/3246 | 137/18723 | 1.60e-03 | 9.71e-03 | 38 |
GO:007218212 | Prostate | Tumor | regulation of nephron tubule epithelial cell differentiation | 7/3246 | 12/18723 | 1.64e-03 | 9.79e-03 | 7 |
GO:00107181 | Prostate | Tumor | positive regulation of epithelial to mesenchymal transition | 18/3246 | 52/18723 | 2.03e-03 | 1.16e-02 | 18 |
GO:000189416 | Prostate | Tumor | tissue homeostasis | 65/3246 | 268/18723 | 2.39e-03 | 1.35e-02 | 65 |
GO:007200913 | Prostate | Tumor | nephron epithelium development | 31/3246 | 109/18723 | 2.70e-03 | 1.48e-02 | 31 |
GO:006024915 | Prostate | Tumor | anatomical structure homeostasis | 74/3246 | 314/18723 | 2.82e-03 | 1.54e-02 | 74 |
GO:003526412 | Prostate | Tumor | multicellular organism growth | 36/3246 | 132/18723 | 2.85e-03 | 1.55e-02 | 36 |
GO:000165612 | Prostate | Tumor | metanephros development | 25/3246 | 85/18723 | 4.12e-03 | 2.08e-02 | 25 |
GO:007208013 | Prostate | Tumor | nephron tubule development | 26/3246 | 91/18723 | 5.32e-03 | 2.54e-02 | 26 |
GO:003532911 | Prostate | Tumor | hippo signaling | 14/3246 | 40/18723 | 5.52e-03 | 2.61e-02 | 14 |
GO:007200613 | Prostate | Tumor | nephron development | 37/3246 | 142/18723 | 5.73e-03 | 2.67e-02 | 37 |
GO:006132612 | Prostate | Tumor | renal tubule development | 26/3246 | 94/18723 | 8.40e-03 | 3.66e-02 | 26 |
GO:003585012 | Prostate | Tumor | epithelial cell differentiation involved in kidney development | 15/3246 | 47/18723 | 1.07e-02 | 4.45e-02 | 15 |
GO:005134830 | Thyroid | HT | negative regulation of transferase activity | 45/1272 | 268/18723 | 1.49e-08 | 1.20e-06 | 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0439014 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
hsa0439023 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa0439033 | Endometrium | EEC | Hippo signaling pathway | 39/1237 | 157/8465 | 4.54e-04 | 3.47e-03 | 2.59e-03 | 39 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa043907 | Lung | IAC | Hippo signaling pathway | 35/1053 | 157/8465 | 3.60e-04 | 3.45e-03 | 2.29e-03 | 35 |
hsa0439012 | Lung | IAC | Hippo signaling pathway | 35/1053 | 157/8465 | 3.60e-04 | 3.45e-03 | 2.29e-03 | 35 |
hsa0439022 | Lung | AIS | Hippo signaling pathway | 34/961 | 157/8465 | 1.36e-04 | 1.63e-03 | 1.05e-03 | 34 |
hsa0439032 | Lung | AIS | Hippo signaling pathway | 34/961 | 157/8465 | 1.36e-04 | 1.63e-03 | 1.05e-03 | 34 |
hsa0439041 | Lung | MIAC | Hippo signaling pathway | 21/507 | 157/8465 | 4.20e-04 | 7.19e-03 | 5.20e-03 | 21 |
hsa0439051 | Lung | MIAC | Hippo signaling pathway | 21/507 | 157/8465 | 4.20e-04 | 7.19e-03 | 5.20e-03 | 21 |
hsa0439016 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
hsa0439017 | Oral cavity | OSCC | Hippo signaling pathway | 86/3704 | 157/8465 | 3.30e-03 | 8.24e-03 | 4.20e-03 | 86 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WWTR1 | SNV | Missense_Mutation | c.32C>T | p.Pro11Leu | p.P11L | Q9GZV5 | protein_coding | deleterious(0) | benign(0.007) | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
WWTR1 | SNV | Missense_Mutation | rs756242761 | c.235N>T | p.Ala79Ser | p.A79S | Q9GZV5 | protein_coding | tolerated(0.47) | benign(0.038) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WWTR1 | deletion | Frame_Shift_Del | novel | c.666delN | p.Asn223MetfsTer3 | p.N223Mfs*3 | Q9GZV5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
WWTR1 | SNV | Missense_Mutation | novel | c.1125N>T | p.Glu375Asp | p.E375D | Q9GZV5 | protein_coding | deleterious(0.02) | benign(0.124) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WWTR1 | SNV | Missense_Mutation | c.872N>C | p.Ile291Thr | p.I291T | Q9GZV5 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WWTR1 | SNV | Missense_Mutation | c.14N>T | p.Ser5Leu | p.S5L | Q9GZV5 | protein_coding | deleterious_low_confidence(0.01) | benign(0.028) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WWTR1 | deletion | Frame_Shift_Del | c.603delC | p.Ser202ValfsTer3 | p.S202Vfs*3 | Q9GZV5 | protein_coding | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
WWTR1 | SNV | Missense_Mutation | novel | c.910N>A | p.Pro304Thr | p.P304T | Q9GZV5 | protein_coding | tolerated(1) | benign(0.006) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
WWTR1 | SNV | Missense_Mutation | rs766572084 | c.671C>T | p.Ala224Val | p.A224V | Q9GZV5 | protein_coding | tolerated(0.08) | benign(0.23) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
WWTR1 | SNV | Missense_Mutation | novel | c.364G>A | p.Asp122Asn | p.D122N | Q9GZV5 | protein_coding | deleterious(0) | benign(0.169) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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