![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SIRT2 |
Gene summary for SIRT2 |
![]() |
Gene information | Species | Human | Gene symbol | SIRT2 | Gene ID | 22933 |
Gene name | sirtuin 2 | |
Gene Alias | SIR2 | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A0A0MRF5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22933 | SIRT2 | LZE2T | Human | Esophagus | ESCC | 4.48e-02 | 1.98e-01 | 0.082 |
22933 | SIRT2 | LZE4T | Human | Esophagus | ESCC | 4.05e-14 | 3.10e-01 | 0.0811 |
22933 | SIRT2 | LZE7T | Human | Esophagus | ESCC | 1.29e-04 | 2.03e-01 | 0.0667 |
22933 | SIRT2 | LZE8T | Human | Esophagus | ESCC | 3.31e-09 | 1.32e-01 | 0.067 |
22933 | SIRT2 | LZE20T | Human | Esophagus | ESCC | 2.91e-03 | -2.22e-02 | 0.0662 |
22933 | SIRT2 | LZE22D1 | Human | Esophagus | HGIN | 9.77e-07 | 1.27e-01 | 0.0595 |
22933 | SIRT2 | LZE24T | Human | Esophagus | ESCC | 4.70e-09 | 2.45e-01 | 0.0596 |
22933 | SIRT2 | LZE6T | Human | Esophagus | ESCC | 2.36e-03 | 2.38e-02 | 0.0845 |
22933 | SIRT2 | P1T-E | Human | Esophagus | ESCC | 2.30e-15 | 9.91e-01 | 0.0875 |
22933 | SIRT2 | P2T-E | Human | Esophagus | ESCC | 8.87e-17 | 3.32e-01 | 0.1177 |
22933 | SIRT2 | P4T-E | Human | Esophagus | ESCC | 3.42e-16 | 3.44e-01 | 0.1323 |
22933 | SIRT2 | P5T-E | Human | Esophagus | ESCC | 3.56e-09 | 8.50e-02 | 0.1327 |
22933 | SIRT2 | P8T-E | Human | Esophagus | ESCC | 6.70e-35 | 6.80e-01 | 0.0889 |
22933 | SIRT2 | P9T-E | Human | Esophagus | ESCC | 2.73e-08 | 1.32e-01 | 0.1131 |
22933 | SIRT2 | P10T-E | Human | Esophagus | ESCC | 5.18e-30 | 6.59e-01 | 0.116 |
22933 | SIRT2 | P11T-E | Human | Esophagus | ESCC | 2.53e-16 | 7.47e-01 | 0.1426 |
22933 | SIRT2 | P12T-E | Human | Esophagus | ESCC | 1.97e-18 | 3.79e-01 | 0.1122 |
22933 | SIRT2 | P15T-E | Human | Esophagus | ESCC | 1.29e-16 | 3.30e-01 | 0.1149 |
22933 | SIRT2 | P16T-E | Human | Esophagus | ESCC | 5.53e-16 | 1.76e-01 | 0.1153 |
22933 | SIRT2 | P17T-E | Human | Esophagus | ESCC | 4.16e-06 | 4.33e-01 | 0.1278 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006141812 | Thyroid | PTC | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 9/5968 | 13/18723 | 6.33e-03 | 2.79e-02 | 9 |
GO:00709333 | Thyroid | PTC | histone H4 deacetylation | 8/5968 | 11/18723 | 6.50e-03 | 2.83e-02 | 8 |
GO:001470617 | Thyroid | PTC | striated muscle tissue development | 144/5968 | 384/18723 | 1.05e-02 | 4.22e-02 | 144 |
GO:00107991 | Thyroid | PTC | regulation of peptidyl-threonine phosphorylation | 23/5968 | 47/18723 | 1.09e-02 | 4.35e-02 | 23 |
GO:00064712 | Thyroid | PTC | protein ADP-ribosylation | 18/5968 | 35/18723 | 1.26e-02 | 4.90e-02 | 18 |
GO:00140375 | Thyroid | PTC | Schwann cell differentiation | 20/5968 | 40/18723 | 1.28e-02 | 4.95e-02 | 20 |
GO:001049832 | Thyroid | ATC | proteasomal protein catabolic process | 309/6293 | 490/18723 | 1.78e-41 | 1.13e-37 | 309 |
GO:0043161210 | Thyroid | ATC | proteasome-mediated ubiquitin-dependent protein catabolic process | 265/6293 | 412/18723 | 7.09e-38 | 1.49e-34 | 265 |
GO:0009896210 | Thyroid | ATC | positive regulation of catabolic process | 290/6293 | 492/18723 | 2.15e-31 | 1.94e-28 | 290 |
GO:0031331210 | Thyroid | ATC | positive regulation of cellular catabolic process | 258/6293 | 427/18723 | 2.09e-30 | 1.65e-27 | 258 |
GO:004217635 | Thyroid | ATC | regulation of protein catabolic process | 239/6293 | 391/18723 | 2.63e-29 | 1.85e-26 | 239 |
GO:190336235 | Thyroid | ATC | regulation of cellular protein catabolic process | 168/6293 | 255/18723 | 3.50e-26 | 1.58e-23 | 168 |
GO:190305035 | Thyroid | ATC | regulation of proteolysis involved in cellular protein catabolic process | 146/6293 | 221/18723 | 4.18e-23 | 1.20e-20 | 146 |
GO:006113633 | Thyroid | ATC | regulation of proteasomal protein catabolic process | 128/6293 | 187/18723 | 1.63e-22 | 4.30e-20 | 128 |
GO:2000058210 | Thyroid | ATC | regulation of ubiquitin-dependent protein catabolic process | 116/6293 | 164/18723 | 2.15e-22 | 5.43e-20 | 116 |
GO:0032434210 | Thyroid | ATC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 100/6293 | 134/18723 | 2.41e-22 | 5.86e-20 | 100 |
GO:0045732210 | Thyroid | ATC | positive regulation of protein catabolic process | 148/6293 | 231/18723 | 1.93e-21 | 4.36e-19 | 148 |
GO:000697934 | Thyroid | ATC | response to oxidative stress | 246/6293 | 446/18723 | 2.98e-21 | 6.09e-19 | 246 |
GO:190336434 | Thyroid | ATC | positive regulation of cellular protein catabolic process | 109/6293 | 155/18723 | 8.26e-21 | 1.49e-18 | 109 |
GO:014001416 | Thyroid | ATC | mitotic nuclear division | 171/6293 | 287/18723 | 1.13e-19 | 1.66e-17 | 171 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIRT2 | SNV | Missense_Mutation | c.562N>A | p.Gly188Ser | p.G188S | Q8IXJ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
SIRT2 | SNV | Missense_Mutation | rs199855116 | c.1036C>T | p.Arg346Trp | p.R346W | Q8IXJ6 | protein_coding | deleterious(0) | possibly_damaging(0.466) | TCGA-D8-A1Y3-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
SIRT2 | SNV | Missense_Mutation | novel | c.1150N>A | p.Glu384Lys | p.E384K | Q8IXJ6 | protein_coding | tolerated_low_confidence(0.1) | benign(0.049) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
SIRT2 | SNV | Missense_Mutation | novel | c.788C>A | p.Ser263Tyr | p.S263Y | Q8IXJ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SIRT2 | SNV | Missense_Mutation | rs200811137 | c.1048G>A | p.Ala350Thr | p.A350T | Q8IXJ6 | protein_coding | tolerated(0.35) | benign(0.006) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SIRT2 | SNV | Missense_Mutation | c.911N>A | p.Gly304Glu | p.G304E | Q8IXJ6 | protein_coding | tolerated(0.18) | benign(0.015) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
SIRT2 | SNV | Missense_Mutation | c.94N>A | p.Ala32Thr | p.A32T | Q8IXJ6 | protein_coding | tolerated(0.46) | benign(0) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIRT2 | SNV | Missense_Mutation | rs200616294 | c.586N>A | p.Val196Ile | p.V196I | Q8IXJ6 | protein_coding | tolerated(0.52) | benign(0.001) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
SIRT2 | SNV | Missense_Mutation | rs199856206 | c.383N>T | p.Pro128Leu | p.P128L | Q8IXJ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SIRT2 | SNV | Missense_Mutation | c.389N>A | p.Pro130His | p.P130H | Q8IXJ6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | ZINC915379 | |||
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | BDBM50363782 | |||
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | GW5074 | CHEMBL1794051 | 20030343 | |
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | US9359293, TM | |||
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | BDBM50363773 | |||
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | inhibitor | 249565779 | ||
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | AC1LOJYQ | |||
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | US9359293, TB | |||
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | AC1LFGWU | |||
22933 | SIRT2 | TRANSCRIPTION FACTOR BINDING, TUMOR SUPPRESSOR, DRUGGABLE GENOME, ENZYME, KINASE, TRANSCRIPTION FACTOR | TRICHOSTATIN | TRICHOSTATIN | 20030343,17149860 |
Page: 1 2 |