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Gene: MIF |
Gene summary for MIF |
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Gene information | Species | Human | Gene symbol | MIF | Gene ID | 4282 |
Gene name | macrophage migration inhibitory factor | |
Gene Alias | GIF | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | I4AY87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4282 | MIF | GSM4909281 | Human | Breast | IDC | 1.08e-77 | 6.83e-01 | 0.21 |
4282 | MIF | GSM4909285 | Human | Breast | IDC | 3.07e-22 | -3.93e-01 | 0.21 |
4282 | MIF | GSM4909286 | Human | Breast | IDC | 8.78e-17 | 4.21e-01 | 0.1081 |
4282 | MIF | GSM4909287 | Human | Breast | IDC | 1.14e-64 | 6.20e-01 | 0.2057 |
4282 | MIF | GSM4909288 | Human | Breast | IDC | 1.58e-02 | -2.18e-01 | 0.0988 |
4282 | MIF | GSM4909289 | Human | Breast | IDC | 8.47e-24 | 6.06e-01 | 0.1064 |
4282 | MIF | GSM4909290 | Human | Breast | IDC | 6.70e-79 | 7.59e-01 | 0.2096 |
4282 | MIF | GSM4909291 | Human | Breast | IDC | 8.23e-96 | 9.02e-01 | 0.1753 |
4282 | MIF | GSM4909292 | Human | Breast | IDC | 1.56e-10 | 4.37e-01 | 0.1236 |
4282 | MIF | GSM4909293 | Human | Breast | IDC | 8.84e-15 | -2.18e-01 | 0.1581 |
4282 | MIF | GSM4909294 | Human | Breast | IDC | 5.48e-12 | 1.47e-01 | 0.2022 |
4282 | MIF | GSM4909296 | Human | Breast | IDC | 2.28e-100 | 7.95e-01 | 0.1524 |
4282 | MIF | GSM4909297 | Human | Breast | IDC | 4.42e-22 | 9.80e-02 | 0.1517 |
4282 | MIF | GSM4909298 | Human | Breast | IDC | 1.16e-07 | 3.32e-01 | 0.1551 |
4282 | MIF | GSM4909300 | Human | Breast | IDC | 1.08e-14 | 4.42e-01 | 0.0334 |
4282 | MIF | GSM4909301 | Human | Breast | IDC | 1.40e-12 | 3.11e-01 | 0.1577 |
4282 | MIF | GSM4909302 | Human | Breast | IDC | 1.21e-18 | 2.14e-01 | 0.1545 |
4282 | MIF | GSM4909305 | Human | Breast | IDC | 4.92e-06 | 2.89e-01 | 0.0436 |
4282 | MIF | GSM4909306 | Human | Breast | IDC | 4.10e-81 | 7.13e-01 | 0.1564 |
4282 | MIF | GSM4909307 | Human | Breast | IDC | 6.23e-27 | 4.11e-01 | 0.1569 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00466517 | Oral cavity | OSCC | lymphocyte proliferation | 131/7305 | 288/18723 | 1.41e-02 | 4.67e-02 | 131 |
GO:00706657 | Oral cavity | OSCC | positive regulation of leukocyte proliferation | 72/7305 | 150/18723 | 1.53e-02 | 4.95e-02 | 72 |
GO:00066363 | Oral cavity | OSCC | unsaturated fatty acid biosynthetic process | 28/7305 | 51/18723 | 1.54e-02 | 4.99e-02 | 28 |
GO:0097193110 | Oral cavity | LP | intrinsic apoptotic signaling pathway | 146/4623 | 288/18723 | 9.76e-22 | 2.78e-19 | 146 |
GO:2001233110 | Oral cavity | LP | regulation of apoptotic signaling pathway | 168/4623 | 356/18723 | 1.35e-20 | 3.02e-18 | 168 |
GO:2001242110 | Oral cavity | LP | regulation of intrinsic apoptotic signaling pathway | 95/4623 | 164/18723 | 9.85e-20 | 1.99e-17 | 95 |
GO:000641319 | Oral cavity | LP | translational initiation | 75/4623 | 118/18723 | 3.96e-19 | 7.52e-17 | 75 |
GO:2001243110 | Oral cavity | LP | negative regulation of intrinsic apoptotic signaling pathway | 56/4623 | 98/18723 | 6.93e-12 | 5.48e-10 | 56 |
GO:2001234110 | Oral cavity | LP | negative regulation of apoptotic signaling pathway | 102/4623 | 224/18723 | 7.22e-12 | 5.58e-10 | 102 |
GO:000644616 | Oral cavity | LP | regulation of translational initiation | 48/4623 | 79/18723 | 1.04e-11 | 7.66e-10 | 48 |
GO:0045727110 | Oral cavity | LP | positive regulation of translation | 68/4623 | 136/18723 | 1.53e-10 | 8.51e-09 | 68 |
GO:0006417110 | Oral cavity | LP | regulation of translation | 175/4623 | 468/18723 | 4.49e-10 | 2.22e-08 | 175 |
GO:0034250110 | Oral cavity | LP | positive regulation of cellular amide metabolic process | 76/4623 | 162/18723 | 6.11e-10 | 2.97e-08 | 76 |
GO:000863019 | Oral cavity | LP | intrinsic apoptotic signaling pathway in response to DNA damage | 51/4623 | 99/18723 | 8.01e-09 | 3.20e-07 | 51 |
GO:0072331110 | Oral cavity | LP | signal transduction by p53 class mediator | 72/4623 | 163/18723 | 3.99e-08 | 1.41e-06 | 72 |
GO:000756819 | Oral cavity | LP | aging | 125/4623 | 339/18723 | 3.29e-07 | 9.62e-06 | 125 |
GO:0072332110 | Oral cavity | LP | intrinsic apoptotic signaling pathway by p53 class mediator | 39/4623 | 76/18723 | 5.10e-07 | 1.40e-05 | 39 |
GO:004277119 | Oral cavity | LP | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 25/4623 | 43/18723 | 3.00e-06 | 6.47e-05 | 25 |
GO:1901796110 | Oral cavity | LP | regulation of signal transduction by p53 class mediator | 42/4623 | 93/18723 | 1.31e-05 | 2.33e-04 | 42 |
GO:200102018 | Oral cavity | LP | regulation of response to DNA damage stimulus | 82/4623 | 219/18723 | 1.71e-05 | 2.97e-04 | 82 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | ADJ |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | DCIS |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | DCIS |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | DCIS |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Healthy |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Healthy |
MIF | ACKR3 | MIF_ACKR3 | MIF | Breast | Healthy |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | IDC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | IDC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Breast | Precancer |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Breast | Precancer |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | ADJ |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | ADJ |
MIF | ACKR3 | MIF_ACKR3 | MIF | Cervix | ADJ |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | CC |
MIF | CD74_CD44 | MIF_CD74_CD44 | MIF | Cervix | CC |
MIF | ACKR3 | MIF_ACKR3 | MIF | Cervix | CC |
MIF | CD74_CXCR4 | MIF_CD74_CXCR4 | MIF | Cervix | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIF | SNV | Missense_Mutation | novel | c.266N>C | p.Arg89Pro | p.R89P | P14174 | protein_coding | tolerated(0.21) | benign(0.219) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MIF | insertion | Frame_Shift_Ins | rs767392036 | c.99_100insC | p.Gln36ProfsTer? | p.Q36Pfs*? | P14174 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIF | SNV | Missense_Mutation | novel | c.95N>A | p.Gly32Asp | p.G32D | P14174 | protein_coding | tolerated(0.06) | benign(0.136) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MIF | insertion | Frame_Shift_Ins | rs767392036 | c.99_100insC | p.Gln36ProfsTer? | p.Q36Pfs*? | P14174 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MIF | SNV | Missense_Mutation | c.52N>T | p.Gly18Trp | p.G18W | P14174 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | ANTI-MIF MONOCLONAL ANTIBODY | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | COR100140 | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | PPD | 393437 | ||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | Anti-MIF antibodies | 22238348 | ||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | TCMDC-124484 | CHEMBL524449 | 21719283 | |
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | ISO-1 | |||
4282 | MIF | DRUGGABLE GENOME, CELL SURFACE | PMA | 3305746 |
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