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Gene: EDN1 |
Gene summary for EDN1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | EDN1 | Gene ID | 1906 |
| Gene name | endothelin 1 | |
| Gene Alias | ARCND3 | |
| Cytomap | 6p24.1 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P05305 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1906 | EDN1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.20e-08 | 6.73e-01 | -0.0811 |
| 1906 | EDN1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.64e-08 | 3.18e-01 | -0.1954 |
| 1906 | EDN1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.11e-04 | 3.55e-01 | 0.0588 |
| 1906 | EDN1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.92e-16 | 7.07e-01 | 0.281 |
| 1906 | EDN1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.37e-02 | 1.20e-01 | 0.3859 |
| 1906 | EDN1 | A002-C-203 | Human | Colorectum | FAP | 3.23e-04 | 2.57e-01 | 0.2786 |
| 1906 | EDN1 | A001-C-108 | Human | Colorectum | FAP | 1.25e-09 | 4.49e-01 | -0.0272 |
| 1906 | EDN1 | A001-C-104 | Human | Colorectum | FAP | 2.57e-10 | 4.46e-01 | 0.0184 |
| 1906 | EDN1 | A001-C-014 | Human | Colorectum | FAP | 1.01e-02 | 1.82e-01 | 0.0135 |
| 1906 | EDN1 | A001-C-203 | Human | Colorectum | FAP | 8.84e-07 | 3.38e-01 | -0.0481 |
| 1906 | EDN1 | A008-E-015 | Human | Colorectum | FAP | 5.76e-04 | 1.90e-01 | 0.0177 |
| 1906 | EDN1 | LZE4T | Human | Esophagus | ESCC | 2.68e-17 | 1.08e+00 | 0.0811 |
| 1906 | EDN1 | LZE7T | Human | Esophagus | ESCC | 3.83e-09 | 1.57e+00 | 0.0667 |
| 1906 | EDN1 | LZE22T | Human | Esophagus | ESCC | 2.92e-02 | 1.55e+00 | 0.068 |
| 1906 | EDN1 | LZE24T | Human | Esophagus | ESCC | 2.82e-15 | 1.54e+00 | 0.0596 |
| 1906 | EDN1 | P4T-E | Human | Esophagus | ESCC | 1.02e-06 | 7.29e-01 | 0.1323 |
| 1906 | EDN1 | P5T-E | Human | Esophagus | ESCC | 9.20e-18 | 1.02e+00 | 0.1327 |
| 1906 | EDN1 | P8T-E | Human | Esophagus | ESCC | 2.00e-19 | 1.13e+00 | 0.0889 |
| 1906 | EDN1 | P9T-E | Human | Esophagus | ESCC | 2.01e-24 | 1.31e+00 | 0.1131 |
| 1906 | EDN1 | P10T-E | Human | Esophagus | ESCC | 5.95e-14 | 4.31e-01 | 0.116 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00434103 | Lung | IAC | positive regulation of MAPK cascade | 78/2061 | 480/18723 | 2.72e-04 | 4.50e-03 | 78 |
| GO:0042692 | Lung | IAC | muscle cell differentiation | 65/2061 | 384/18723 | 2.75e-04 | 4.54e-03 | 65 |
| GO:00486394 | Lung | IAC | positive regulation of developmental growth | 35/2061 | 174/18723 | 2.96e-04 | 4.79e-03 | 35 |
| GO:0007585 | Lung | IAC | respiratory gaseous exchange by respiratory system | 18/2061 | 68/18723 | 2.99e-04 | 4.82e-03 | 18 |
| GO:00515924 | Lung | IAC | response to calcium ion | 31/2061 | 149/18723 | 3.47e-04 | 5.42e-03 | 31 |
| GO:00434052 | Lung | IAC | regulation of MAP kinase activity | 35/2061 | 177/18723 | 4.15e-04 | 6.23e-03 | 35 |
| GO:00346127 | Lung | IAC | response to tumor necrosis factor | 46/2061 | 253/18723 | 4.28e-04 | 6.37e-03 | 46 |
| GO:00359943 | Lung | IAC | response to muscle stretch | 9/2061 | 23/18723 | 4.51e-04 | 6.66e-03 | 9 |
| GO:00488633 | Lung | IAC | stem cell differentiation | 38/2061 | 206/18723 | 9.79e-04 | 1.18e-02 | 38 |
| GO:00100388 | Lung | IAC | response to metal ion | 61/2061 | 373/18723 | 1.02e-03 | 1.22e-02 | 61 |
| GO:00900684 | Lung | IAC | positive regulation of cell cycle process | 42/2061 | 236/18723 | 1.15e-03 | 1.35e-02 | 42 |
| GO:00713567 | Lung | IAC | cellular response to tumor necrosis factor | 41/2061 | 229/18723 | 1.16e-03 | 1.35e-02 | 41 |
| GO:00096125 | Lung | IAC | response to mechanical stimulus | 39/2061 | 216/18723 | 1.29e-03 | 1.45e-02 | 39 |
| GO:00030124 | Lung | IAC | muscle system process | 71/2061 | 452/18723 | 1.29e-03 | 1.45e-02 | 71 |
| GO:00611382 | Lung | IAC | morphogenesis of a branching epithelium | 34/2061 | 182/18723 | 1.41e-03 | 1.54e-02 | 34 |
| GO:00513847 | Lung | IAC | response to glucocorticoid | 29/2061 | 148/18723 | 1.44e-03 | 1.55e-02 | 29 |
| GO:00480162 | Lung | IAC | inositol phosphate-mediated signaling | 14/2061 | 55/18723 | 2.04e-03 | 2.05e-02 | 14 |
| GO:00902577 | Lung | IAC | regulation of muscle system process | 43/2061 | 252/18723 | 2.35e-03 | 2.28e-02 | 43 |
| GO:0001961 | Lung | IAC | positive regulation of cytokine-mediated signaling pathway | 13/2061 | 50/18723 | 2.38e-03 | 2.30e-02 | 13 |
| GO:00713855 | Lung | IAC | cellular response to glucocorticoid stimulus | 14/2061 | 56/18723 | 2.45e-03 | 2.33e-02 | 14 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
| hsa05418 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
| hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
| hsa054181 | Colorectum | AD | Fluid shear stress and atherosclerosis | 54/2092 | 139/8465 | 1.41e-04 | 1.16e-03 | 7.37e-04 | 54 |
| hsa054184 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
| hsa040664 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
| hsa04926 | Colorectum | MSS | Relaxin signaling pathway | 40/1875 | 129/8465 | 1.18e-02 | 3.99e-02 | 2.44e-02 | 40 |
| hsa054185 | Colorectum | MSS | Fluid shear stress and atherosclerosis | 51/1875 | 139/8465 | 6.06e-05 | 5.80e-04 | 3.55e-04 | 51 |
| hsa040665 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
| hsa049261 | Colorectum | MSS | Relaxin signaling pathway | 40/1875 | 129/8465 | 1.18e-02 | 3.99e-02 | 2.44e-02 | 40 |
| hsa040666 | Colorectum | FAP | HIF-1 signaling pathway | 38/1404 | 109/8465 | 2.43e-06 | 4.28e-05 | 2.60e-05 | 38 |
| hsa054188 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
| hsa04933 | Colorectum | FAP | AGE-RAGE signaling pathway in diabetic complications | 27/1404 | 100/8465 | 5.55e-03 | 2.15e-02 | 1.31e-02 | 27 |
| hsa04024 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
| hsa04270 | Colorectum | FAP | Vascular smooth muscle contraction | 33/1404 | 134/8465 | 1.05e-02 | 3.74e-02 | 2.28e-02 | 33 |
| hsa040667 | Colorectum | FAP | HIF-1 signaling pathway | 38/1404 | 109/8465 | 2.43e-06 | 4.28e-05 | 2.60e-05 | 38 |
| hsa054189 | Colorectum | FAP | Fluid shear stress and atherosclerosis | 45/1404 | 139/8465 | 3.05e-06 | 4.63e-05 | 2.81e-05 | 45 |
| hsa049331 | Colorectum | FAP | AGE-RAGE signaling pathway in diabetic complications | 27/1404 | 100/8465 | 5.55e-03 | 2.15e-02 | 1.31e-02 | 27 |
| hsa040241 | Colorectum | FAP | cAMP signaling pathway | 51/1404 | 225/8465 | 1.02e-02 | 3.68e-02 | 2.24e-02 | 51 |
| hsa042701 | Colorectum | FAP | Vascular smooth muscle contraction | 33/1404 | 134/8465 | 1.05e-02 | 3.74e-02 | 2.28e-02 | 33 |
| Page: 1 2 3 4 5 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Breast | ADJ |
| EDN1 | EDNRB | EDN1_EDNRB | EDN | Breast | ADJ |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Breast | DCIS |
| EDN1 | EDNRB | EDN1_EDNRB | EDN | Breast | DCIS |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Breast | Healthy |
| EDN1 | EDNRB | EDN1_EDNRB | EDN | Breast | Healthy |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Breast | Precancer |
| EDN1 | EDNRB | EDN1_EDNRB | EDN | Breast | Precancer |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Cervix | ADJ |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Cervix | CC |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | CRC | MSI-H |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Endometrium | ADJ |
| EDN1 | EDNRB | EDN1_EDNRB | EDN | Endometrium | ADJ |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Endometrium | AEH |
| EDN1 | EDNRB | EDN1_EDNRB | EDN | Endometrium | AEH |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Endometrium | EEC |
| EDN1 | EDNRB | EDN1_EDNRB | EDN | Endometrium | EEC |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Endometrium | Healthy |
| EDN1 | EDNRB | EDN1_EDNRB | EDN | Endometrium | Healthy |
| EDN1 | EDNRA | EDN1_EDNRA | EDN | Esophagus | ESCC |
| Page: 1 2 3 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| EDN1 | BAS | Lung | Healthy | KRT17,CXCL1,IER3, etc. | 1.53e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| EDN1 | SNV | Missense_Mutation | c.346N>T | p.Asp116Tyr | p.D116Y | P05305 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| EDN1 | SNV | Missense_Mutation | rs777308039 | c.446C>A | p.Ser149Tyr | p.S149Y | P05305 | protein_coding | tolerated(0.07) | benign(0.121) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| EDN1 | SNV | Missense_Mutation | c.557T>A | p.Val186Asp | p.V186D | P05305 | protein_coding | deleterious(0) | possibly_damaging(0.559) | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
| EDN1 | insertion | Frame_Shift_Ins | novel | c.155_156insTAACTTATCGTTTTATTATTATTATTCCATTATGTGTTTC | p.Cys53AsnfsTer22 | p.C53Nfs*22 | P05305 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
| EDN1 | deletion | Frame_Shift_Del | c.457delN | p.Lys154SerfsTer7 | p.K154Sfs*7 | P05305 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| EDN1 | SNV | Missense_Mutation | c.285N>T | p.Glu95Asp | p.E95D | P05305 | protein_coding | tolerated(0.09) | benign(0.104) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| EDN1 | SNV | Missense_Mutation | novel | c.221N>G | p.Val74Gly | p.V74G | P05305 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| EDN1 | deletion | Frame_Shift_Del | c.457delN | p.Lys154SerfsTer7 | p.K154Sfs*7 | P05305 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
| EDN1 | SNV | Missense_Mutation | rs368802545 | c.143N>A | p.Arg48His | p.R48H | P05305 | protein_coding | tolerated(0.07) | benign(0.031) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| EDN1 | SNV | Missense_Mutation | c.285N>T | p.Glu95Asp | p.E95D | P05305 | protein_coding | tolerated(0.09) | benign(0.104) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
| Page: 1 2 3 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | muraglitazar | MURAGLITAZAR | 18794727 | |
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | ANTICONVULSANT | 7509966 | ||
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | OXYGEN THERAPY | 9736447 | ||
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | ANTIPLATELET AGENT | 15253106 | ||
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | TAMOXIFEN | TAMOXIFEN | 8425178 | |
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | NORETHISTERONE ACETATE | 11915588 | ||
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | CANDESARTAN CILEXETIL | 10029562 | ||
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | INSULIN | INSULIN | 11600523 | |
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | THIOURACIL | THIOURACIL | 10967532 | |
| 1906 | EDN1 | HORMONE ACTIVITY, DRUGGABLE GENOME | CELECOXIB | CELECOXIB | 15539607 |
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