Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/CTNNA1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CTNNA1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CTNNA1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CTNNA1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CTNNA1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CTNNA1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/CTNNA1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CTNNA1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CTNNA1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CTNNA1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CTNNA1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034329110 | Skin | SCCIS | cell junction assembly | 52/919 | 420/18723 | 7.89e-10 | 5.23e-07 | 52 |
GO:0007568110 | Skin | SCCIS | aging | 41/919 | 339/18723 | 9.54e-08 | 1.29e-05 | 41 |
GO:0007163110 | Skin | SCCIS | establishment or maintenance of cell polarity | 31/919 | 218/18723 | 9.72e-08 | 1.29e-05 | 31 |
GO:0048608110 | Skin | SCCIS | reproductive structure development | 47/919 | 424/18723 | 1.60e-07 | 1.85e-05 | 47 |
GO:0061458111 | Skin | SCCIS | reproductive system development | 47/919 | 427/18723 | 1.98e-07 | 2.10e-05 | 47 |
GO:004001315 | Skin | SCCIS | negative regulation of locomotion | 44/919 | 391/18723 | 2.61e-07 | 2.61e-05 | 44 |
GO:2001236112 | Skin | SCCIS | regulation of extrinsic apoptotic signaling pathway | 24/919 | 151/18723 | 3.42e-07 | 3.03e-05 | 24 |
GO:006156417 | Skin | SCCIS | axon development | 49/919 | 467/18723 | 4.63e-07 | 3.77e-05 | 49 |
GO:2001234112 | Skin | SCCIS | negative regulation of apoptotic signaling pathway | 30/919 | 224/18723 | 5.83e-07 | 4.62e-05 | 30 |
GO:200014616 | Skin | SCCIS | negative regulation of cell motility | 40/919 | 359/18723 | 1.17e-06 | 7.78e-05 | 40 |
GO:005127116 | Skin | SCCIS | negative regulation of cellular component movement | 40/919 | 367/18723 | 2.04e-06 | 1.09e-04 | 40 |
GO:2001235111 | Skin | SCCIS | positive regulation of apoptotic signaling pathway | 20/919 | 126/18723 | 3.27e-06 | 1.53e-04 | 20 |
GO:0045216110 | Skin | SCCIS | cell-cell junction organization | 26/919 | 200/18723 | 5.65e-06 | 2.29e-04 | 26 |
GO:200123819 | Skin | SCCIS | positive regulation of extrinsic apoptotic signaling pathway | 11/919 | 48/18723 | 1.59e-05 | 4.98e-04 | 11 |
GO:0097191112 | Skin | SCCIS | extrinsic apoptotic signaling pathway | 26/919 | 219/18723 | 2.87e-05 | 7.82e-04 | 26 |
GO:0007015111 | Skin | SCCIS | actin filament organization | 40/919 | 442/18723 | 1.50e-04 | 3.04e-03 | 40 |
GO:2001237112 | Skin | SCCIS | negative regulation of extrinsic apoptotic signaling pathway | 14/919 | 97/18723 | 2.67e-04 | 4.79e-03 | 14 |
GO:0007043110 | Skin | SCCIS | cell-cell junction assembly | 18/919 | 146/18723 | 2.94e-04 | 5.23e-03 | 18 |
GO:003109918 | Skin | SCCIS | regeneration | 22/919 | 198/18723 | 3.00e-04 | 5.31e-03 | 22 |
GO:1900181 | Skin | SCCIS | negative regulation of protein localization to nucleus | 7/919 | 33/18723 | 9.34e-04 | 1.19e-02 | 7 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0467020 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0510020 | Cervix | CC | Bacterial invasion of epithelial cells | 23/1267 | 77/8465 | 6.25e-04 | 2.93e-03 | 1.73e-03 | 23 |
hsa0521310 | Cervix | CC | Endometrial cancer | 18/1267 | 58/8465 | 1.46e-03 | 6.30e-03 | 3.73e-03 | 18 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa04670110 | Cervix | CC | Leukocyte transendothelial migration | 36/1267 | 114/8465 | 5.22e-06 | 4.83e-05 | 2.86e-05 | 36 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa05100110 | Cervix | CC | Bacterial invasion of epithelial cells | 23/1267 | 77/8465 | 6.25e-04 | 2.93e-03 | 1.73e-03 | 23 |
hsa0521313 | Cervix | CC | Endometrial cancer | 18/1267 | 58/8465 | 1.46e-03 | 6.30e-03 | 3.73e-03 | 18 |
hsa0467025 | Cervix | HSIL_HPV | Leukocyte transendothelial migration | 16/459 | 114/8465 | 4.04e-04 | 3.49e-03 | 2.82e-03 | 16 |
hsa054127 | Cervix | HSIL_HPV | Arrhythmogenic right ventricular cardiomyopathy | 10/459 | 77/8465 | 8.34e-03 | 4.70e-02 | 3.80e-02 | 10 |
hsa0467035 | Cervix | HSIL_HPV | Leukocyte transendothelial migration | 16/459 | 114/8465 | 4.04e-04 | 3.49e-03 | 2.82e-03 | 16 |
hsa0541212 | Cervix | HSIL_HPV | Arrhythmogenic right ventricular cardiomyopathy | 10/459 | 77/8465 | 8.34e-03 | 4.70e-02 | 3.80e-02 | 10 |
hsa0510025 | Cervix | N_HPV | Bacterial invasion of epithelial cells | 10/349 | 77/8465 | 1.17e-03 | 7.93e-03 | 6.20e-03 | 10 |
hsa0467045 | Cervix | N_HPV | Leukocyte transendothelial migration | 12/349 | 114/8465 | 2.50e-03 | 1.45e-02 | 1.13e-02 | 12 |
hsa0510035 | Cervix | N_HPV | Bacterial invasion of epithelial cells | 10/349 | 77/8465 | 1.17e-03 | 7.93e-03 | 6.20e-03 | 10 |
hsa0467055 | Cervix | N_HPV | Leukocyte transendothelial migration | 12/349 | 114/8465 | 2.50e-03 | 1.45e-02 | 1.13e-02 | 12 |
hsa05100 | Colorectum | AD | Bacterial invasion of epithelial cells | 44/2092 | 77/8465 | 1.13e-09 | 2.22e-08 | 1.42e-08 | 44 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTNNA1 | SNV | Missense_Mutation | rs781520852 | c.160N>T | p.Arg54Cys | p.R54C | P35221 | protein_coding | tolerated(0.07) | possibly_damaging(0.873) | TCGA-AC-A3TM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
CTNNA1 | SNV | Missense_Mutation | | c.1294G>C | p.Glu432Gln | p.E432Q | P35221 | protein_coding | tolerated(0.07) | benign(0.405) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CTNNA1 | SNV | Missense_Mutation | | c.1673C>T | p.Ser558Leu | p.S558L | P35221 | protein_coding | deleterious(0) | benign(0.295) | TCGA-BH-A18U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CTNNA1 | insertion | Nonsense_Mutation | novel | c.451_452insAACAAATAAAAGAATGAATGATCTCCATCT | p.Leu151delinsGlnGlnIleLysGluTerMetIleSerIlePhe | p.L151delinsQQIKE*MISIF | P35221 | protein_coding | | | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
CTNNA1 | SNV | Missense_Mutation | | c.2350G>A | p.Ala784Thr | p.A784T | P35221 | protein_coding | tolerated(0.41) | benign(0.131) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CTNNA1 | SNV | Missense_Mutation | novel | c.2411G>A | p.Gly804Asp | p.G804D | P35221 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CTNNA1 | SNV | Missense_Mutation | | c.1939N>C | p.Asp647His | p.D647H | P35221 | protein_coding | deleterious(0.01) | probably_damaging(0.95) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
CTNNA1 | SNV | Missense_Mutation | novel | c.2163N>C | p.Met721Ile | p.M721I | P35221 | protein_coding | deleterious(0.04) | possibly_damaging(0.516) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
CTNNA1 | SNV | Missense_Mutation | novel | c.1027G>A | p.Ala343Thr | p.A343T | P35221 | protein_coding | deleterious(0.02) | benign(0.12) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CTNNA1 | SNV | Missense_Mutation | | c.2397N>T | p.Glu799Asp | p.E799D | P35221 | protein_coding | tolerated(0.88) | benign(0.071) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |