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Gene: PRDX2 |
Gene summary for PRDX2 |
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Gene information | Species | Human | Gene symbol | PRDX2 | Gene ID | 7001 |
Gene name | peroxiredoxin 2 | |
Gene Alias | HEL-S-2a | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | P32119 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7001 | PRDX2 | GSM4909281 | Human | Breast | IDC | 1.18e-02 | 3.08e-01 | 0.21 |
7001 | PRDX2 | GSM4909282 | Human | Breast | IDC | 6.87e-39 | 6.09e-01 | -0.0288 |
7001 | PRDX2 | GSM4909285 | Human | Breast | IDC | 4.48e-60 | 8.36e-01 | 0.21 |
7001 | PRDX2 | GSM4909286 | Human | Breast | IDC | 6.82e-03 | 1.06e-01 | 0.1081 |
7001 | PRDX2 | GSM4909287 | Human | Breast | IDC | 4.67e-12 | 3.41e-01 | 0.2057 |
7001 | PRDX2 | GSM4909289 | Human | Breast | IDC | 7.11e-06 | 4.58e-01 | 0.1064 |
7001 | PRDX2 | GSM4909290 | Human | Breast | IDC | 2.92e-18 | 5.08e-01 | 0.2096 |
7001 | PRDX2 | GSM4909291 | Human | Breast | IDC | 1.69e-03 | 2.53e-01 | 0.1753 |
7001 | PRDX2 | GSM4909293 | Human | Breast | IDC | 5.60e-14 | 4.91e-01 | 0.1581 |
7001 | PRDX2 | GSM4909294 | Human | Breast | IDC | 7.78e-26 | 4.87e-01 | 0.2022 |
7001 | PRDX2 | GSM4909296 | Human | Breast | IDC | 1.93e-27 | 3.68e-01 | 0.1524 |
7001 | PRDX2 | GSM4909297 | Human | Breast | IDC | 2.46e-22 | 1.06e-01 | 0.1517 |
7001 | PRDX2 | GSM4909301 | Human | Breast | IDC | 2.42e-04 | 2.52e-01 | 0.1577 |
7001 | PRDX2 | GSM4909302 | Human | Breast | IDC | 2.82e-07 | 2.14e-01 | 0.1545 |
7001 | PRDX2 | GSM4909304 | Human | Breast | IDC | 6.66e-42 | 7.09e-01 | 0.1636 |
7001 | PRDX2 | GSM4909305 | Human | Breast | IDC | 1.98e-02 | 1.96e-01 | 0.0436 |
7001 | PRDX2 | GSM4909306 | Human | Breast | IDC | 1.79e-20 | 5.49e-01 | 0.1564 |
7001 | PRDX2 | GSM4909307 | Human | Breast | IDC | 1.45e-15 | 4.35e-01 | 0.1569 |
7001 | PRDX2 | GSM4909308 | Human | Breast | IDC | 2.01e-34 | 6.23e-01 | 0.158 |
7001 | PRDX2 | GSM4909309 | Human | Breast | IDC | 4.81e-02 | 9.66e-02 | 0.0483 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:2001234110 | Oral cavity | LP | negative regulation of apoptotic signaling pathway | 102/4623 | 224/18723 | 7.22e-12 | 5.58e-10 | 102 |
GO:0000302110 | Oral cavity | LP | response to reactive oxygen species | 95/4623 | 222/18723 | 2.23e-09 | 9.98e-08 | 95 |
GO:0062197110 | Oral cavity | LP | cellular response to chemical stress | 130/4623 | 337/18723 | 8.94e-09 | 3.52e-07 | 130 |
GO:0097191110 | Oral cavity | LP | extrinsic apoptotic signaling pathway | 91/4623 | 219/18723 | 2.69e-08 | 9.80e-07 | 91 |
GO:0034599110 | Oral cavity | LP | cellular response to oxidative stress | 110/4623 | 288/18723 | 2.19e-07 | 6.65e-06 | 110 |
GO:200037717 | Oral cavity | LP | regulation of reactive oxygen species metabolic process | 67/4623 | 157/18723 | 5.54e-07 | 1.51e-05 | 67 |
GO:2001236110 | Oral cavity | LP | regulation of extrinsic apoptotic signaling pathway | 63/4623 | 151/18723 | 2.98e-06 | 6.47e-05 | 63 |
GO:0048732110 | Oral cavity | LP | gland development | 149/4623 | 436/18723 | 4.51e-06 | 9.17e-05 | 149 |
GO:005109015 | Oral cavity | LP | regulation of DNA-binding transcription factor activity | 147/4623 | 440/18723 | 2.00e-05 | 3.35e-04 | 147 |
GO:000283211 | Oral cavity | LP | negative regulation of response to biotic stimulus | 46/4623 | 108/18723 | 3.31e-05 | 5.02e-04 | 46 |
GO:0034614110 | Oral cavity | LP | cellular response to reactive oxygen species | 61/4623 | 155/18723 | 3.66e-05 | 5.43e-04 | 61 |
GO:0042060110 | Oral cavity | LP | wound healing | 139/4623 | 422/18723 | 7.10e-05 | 9.48e-04 | 139 |
GO:007259317 | Oral cavity | LP | reactive oxygen species metabolic process | 85/4623 | 239/18723 | 1.04e-04 | 1.26e-03 | 85 |
GO:000283112 | Oral cavity | LP | regulation of response to biotic stimulus | 109/4623 | 327/18723 | 2.45e-04 | 2.60e-03 | 109 |
GO:003249618 | Oral cavity | LP | response to lipopolysaccharide | 112/4623 | 343/18723 | 4.90e-04 | 4.60e-03 | 112 |
GO:007121616 | Oral cavity | LP | cellular response to biotic stimulus | 84/4623 | 246/18723 | 5.17e-04 | 4.82e-03 | 84 |
GO:004545418 | Oral cavity | LP | cell redox homeostasis | 18/4623 | 35/18723 | 5.86e-04 | 5.39e-03 | 18 |
GO:2001237110 | Oral cavity | LP | negative regulation of extrinsic apoptotic signaling pathway | 38/4623 | 97/18723 | 1.11e-03 | 9.13e-03 | 38 |
GO:000223718 | Oral cavity | LP | response to molecule of bacterial origin | 115/4623 | 363/18723 | 1.42e-03 | 1.13e-02 | 115 |
GO:000963619 | Oral cavity | LP | response to toxic substance | 86/4623 | 262/18723 | 1.74e-03 | 1.32e-02 | 86 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRDX2 | SNV | Missense_Mutation | novel | c.544A>T | p.Thr182Ser | p.T182S | P32119 | protein_coding | deleterious(0.03) | possibly_damaging(0.515) | TCGA-A7-A4SA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
PRDX2 | SNV | Missense_Mutation | novel | c.565N>T | p.Asp189Tyr | p.D189Y | P32119 | protein_coding | deleterious(0.01) | benign(0.102) | TCGA-OL-A66L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRDX2 | insertion | Frame_Shift_Ins | novel | c.245_246insGGGAGGAGGTTGCAGTAAG | p.His83GlyfsTer30 | p.H83Gfs*30 | P32119 | protein_coding | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PRDX2 | SNV | Missense_Mutation | novel | c.169N>A | p.Ala57Thr | p.A57T | P32119 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PRDX2 | SNV | Missense_Mutation | novel | c.452C>T | p.Ser151Phe | p.S151F | P32119 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PRDX2 | SNV | Missense_Mutation | rs534702204 | c.334T>C | p.Ser112Pro | p.S112P | P32119 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PRDX2 | SNV | Missense_Mutation | rs755166073 | c.448N>T | p.Arg150Cys | p.R150C | P32119 | protein_coding | deleterious(0.05) | probably_damaging(0.98) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PRDX2 | SNV | Missense_Mutation | rs764907738 | c.559N>A | p.Val187Met | p.V187M | P32119 | protein_coding | tolerated(0.06) | benign(0.376) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PRDX2 | SNV | Missense_Mutation | rs369634820 | c.272G>A | p.Arg91Gln | p.R91Q | P32119 | protein_coding | deleterious(0.03) | possibly_damaging(0.74) | TCGA-D5-7000-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRDX2 | SNV | Missense_Mutation | c.38N>T | p.Pro13Leu | p.P13L | P32119 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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