Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/MUC1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/MUC1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/MUC1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/MUC1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/MUC1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MUC1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/MUC1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/MUC1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/MUC1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/MUC1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/MUC1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MUC1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123318 | Prostate | BPH | regulation of apoptotic signaling pathway | 134/3107 | 356/18723 | 5.06e-22 | 7.84e-19 | 134 |
GO:009719318 | Prostate | BPH | intrinsic apoptotic signaling pathway | 110/3107 | 288/18723 | 7.36e-19 | 2.85e-16 | 110 |
GO:200124218 | Prostate | BPH | regulation of intrinsic apoptotic signaling pathway | 70/3107 | 164/18723 | 2.34e-15 | 3.72e-13 | 70 |
GO:007233118 | Prostate | BPH | signal transduction by p53 class mediator | 64/3107 | 163/18723 | 3.51e-12 | 2.82e-10 | 64 |
GO:200123418 | Prostate | BPH | negative regulation of apoptotic signaling pathway | 79/3107 | 224/18723 | 7.67e-12 | 5.94e-10 | 79 |
GO:004362018 | Prostate | BPH | regulation of DNA-templated transcription in response to stress | 28/3107 | 53/18723 | 1.57e-09 | 6.70e-08 | 28 |
GO:007233217 | Prostate | BPH | intrinsic apoptotic signaling pathway by p53 class mediator | 34/3107 | 76/18723 | 8.04e-09 | 2.77e-07 | 34 |
GO:200124318 | Prostate | BPH | negative regulation of intrinsic apoptotic signaling pathway | 40/3107 | 98/18723 | 1.03e-08 | 3.44e-07 | 40 |
GO:190179618 | Prostate | BPH | regulation of signal transduction by p53 class mediator | 38/3107 | 93/18723 | 2.31e-08 | 6.99e-07 | 38 |
GO:004361818 | Prostate | BPH | regulation of transcription from RNA polymerase II promoter in response to stress | 24/3107 | 47/18723 | 5.48e-08 | 1.50e-06 | 24 |
GO:00447727 | Prostate | BPH | mitotic cell cycle phase transition | 112/3107 | 424/18723 | 1.57e-07 | 3.58e-06 | 112 |
GO:00165706 | Prostate | BPH | histone modification | 120/3107 | 463/18723 | 1.73e-07 | 3.89e-06 | 120 |
GO:003033016 | Prostate | BPH | DNA damage response, signal transduction by p53 class mediator | 30/3107 | 72/18723 | 4.09e-07 | 8.44e-06 | 30 |
GO:00073468 | Prostate | BPH | regulation of mitotic cell cycle | 115/3107 | 457/18723 | 1.52e-06 | 2.62e-05 | 115 |
GO:00071628 | Prostate | BPH | negative regulation of cell adhesion | 82/3107 | 303/18723 | 2.51e-06 | 4.04e-05 | 82 |
GO:00448435 | Prostate | BPH | cell cycle G1/S phase transition | 68/3107 | 241/18723 | 3.80e-06 | 5.83e-05 | 68 |
GO:00000825 | Prostate | BPH | G1/S transition of mitotic cell cycle | 62/3107 | 214/18723 | 3.93e-06 | 5.97e-05 | 62 |
GO:003600310 | Prostate | BPH | positive regulation of transcription from RNA polymerase II promoter in response to stress | 14/3107 | 24/18723 | 4.33e-06 | 6.49e-05 | 14 |
GO:00182055 | Prostate | BPH | peptidyl-lysine modification | 96/3107 | 376/18723 | 5.70e-06 | 8.39e-05 | 96 |
GO:000863016 | Prostate | BPH | intrinsic apoptotic signaling pathway in response to DNA damage | 34/3107 | 99/18723 | 1.29e-05 | 1.70e-04 | 34 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC1 | SNV | Missense_Mutation | novel | c.640C>A | p.Pro214Thr | p.P214T | | protein_coding | tolerated(0.08) | possibly_damaging(0.503) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
MUC1 | SNV | Missense_Mutation | | c.1102N>T | p.Val368Phe | p.V368F | | protein_coding | deleterious(0.05) | benign(0.186) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD |
MUC1 | SNV | Missense_Mutation | novel | c.998C>A | p.Thr333Asn | p.T333N | | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-D8-A1XC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MUC1 | deletion | Frame_Shift_Del | novel | c.643_697delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Ala215ProfsTer100 | p.A215Pfs*100 | | protein_coding | | | TCGA-E2-A15S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
MUC1 | SNV | Missense_Mutation | rs759820018 | c.247N>G | p.Gln83Glu | p.Q83E | | protein_coding | tolerated(0.8) | benign(0.101) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MUC1 | SNV | Missense_Mutation | novel | c.620N>G | p.Ser207Cys | p.S207C | | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-HM-A3JJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
MUC1 | SNV | Missense_Mutation | novel | c.701N>G | p.Leu234Arg | p.L234R | | protein_coding | tolerated(0.37) | benign(0.299) | TCGA-R2-A69V-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
MUC1 | SNV | Missense_Mutation | novel | c.1183N>A | p.Leu395Met | p.L395M | | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MUC1 | SNV | Missense_Mutation | novel | c.854N>T | p.Ser285Phe | p.S285F | | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MUC1 | SNV | Missense_Mutation | novel | c.175G>A | p.Glu59Lys | p.E59K | | protein_coding | tolerated(0.48) | possibly_damaging(0.497) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | Anti-MUC1 mab | | |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | G0-203-2c | | |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | SODIUM BUTYRATE | | 2211839 |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | MUC-1 CART cell immunotherapy | | |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | Pankomab-GEX | | |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | BREVAREX MAB | | |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | AS-1402 | HUHMFG1 | |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | SAR-566658 | SAR-566658 | |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | GO-203-2c | GO-203-2C | |
4582 | MUC1 | CLINICALLY ACTIONABLE, ENZYME, DRUGGABLE GENOME | | AS1402 | HUHMFG1 | |