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Gene: ME2 |
Gene summary for ME2 |
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Gene information | Species | Human | Gene symbol | ME2 | Gene ID | 4200 |
Gene name | malic enzyme 2 | |
Gene Alias | ODS1 | |
Cytomap | 18q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | P23368 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4200 | ME2 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.06e-05 | 3.20e-01 | -0.1954 |
4200 | ME2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.68e-02 | -1.89e-01 | -0.1464 |
4200 | ME2 | A002-C-010 | Human | Colorectum | FAP | 2.99e-02 | -1.63e-01 | 0.242 |
4200 | ME2 | A001-C-207 | Human | Colorectum | FAP | 8.50e-04 | -3.23e-01 | 0.1278 |
4200 | ME2 | A015-C-203 | Human | Colorectum | FAP | 6.11e-16 | -2.57e-01 | -0.1294 |
4200 | ME2 | A002-C-201 | Human | Colorectum | FAP | 3.19e-09 | -3.41e-01 | 0.0324 |
4200 | ME2 | A002-C-203 | Human | Colorectum | FAP | 1.78e-04 | -2.28e-01 | 0.2786 |
4200 | ME2 | A001-C-119 | Human | Colorectum | FAP | 1.50e-02 | -2.75e-01 | -0.1557 |
4200 | ME2 | A001-C-108 | Human | Colorectum | FAP | 2.45e-14 | -2.82e-01 | -0.0272 |
4200 | ME2 | A002-C-205 | Human | Colorectum | FAP | 6.00e-11 | -3.55e-01 | -0.1236 |
4200 | ME2 | A015-C-005 | Human | Colorectum | FAP | 2.20e-03 | -2.89e-01 | -0.0336 |
4200 | ME2 | A015-C-006 | Human | Colorectum | FAP | 1.79e-06 | -3.20e-01 | -0.0994 |
4200 | ME2 | A015-C-106 | Human | Colorectum | FAP | 7.19e-04 | -1.77e-01 | -0.0511 |
4200 | ME2 | A002-C-114 | Human | Colorectum | FAP | 7.03e-09 | -3.07e-01 | -0.1561 |
4200 | ME2 | A015-C-104 | Human | Colorectum | FAP | 5.39e-18 | -3.47e-01 | -0.1899 |
4200 | ME2 | A001-C-014 | Human | Colorectum | FAP | 1.05e-06 | -3.08e-01 | 0.0135 |
4200 | ME2 | A002-C-016 | Human | Colorectum | FAP | 1.31e-13 | -2.37e-01 | 0.0521 |
4200 | ME2 | A015-C-002 | Human | Colorectum | FAP | 4.21e-07 | -4.38e-01 | -0.0763 |
4200 | ME2 | A001-C-203 | Human | Colorectum | FAP | 4.24e-05 | -2.15e-01 | -0.0481 |
4200 | ME2 | A002-C-116 | Human | Colorectum | FAP | 5.46e-12 | -2.56e-01 | -0.0452 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000616417 | Esophagus | ESCC | purine nucleotide biosynthetic process | 113/8552 | 191/18723 | 1.16e-04 | 8.04e-04 | 113 |
GO:000920118 | Esophagus | ESCC | ribonucleoside triphosphate biosynthetic process | 50/8552 | 74/18723 | 1.16e-04 | 8.04e-04 | 50 |
GO:005067318 | Esophagus | ESCC | epithelial cell proliferation | 238/8552 | 437/18723 | 1.19e-04 | 8.20e-04 | 238 |
GO:000913219 | Esophagus | ESCC | nucleoside diphosphate metabolic process | 77/8552 | 124/18723 | 1.65e-04 | 1.09e-03 | 77 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:1903706110 | Esophagus | ESCC | regulation of hemopoiesis | 201/8552 | 367/18723 | 2.60e-04 | 1.58e-03 | 201 |
GO:00072299 | Esophagus | ESCC | integrin-mediated signaling pathway | 67/8552 | 107/18723 | 3.03e-04 | 1.81e-03 | 67 |
GO:000914519 | Esophagus | ESCC | purine nucleoside triphosphate biosynthetic process | 46/8552 | 69/18723 | 3.46e-04 | 2.03e-03 | 46 |
GO:00062203 | Esophagus | ESCC | pyrimidine nucleotide metabolic process | 35/8552 | 50/18723 | 4.33e-04 | 2.44e-03 | 35 |
GO:00091473 | Esophagus | ESCC | pyrimidine nucleoside triphosphate metabolic process | 20/8552 | 25/18723 | 4.81e-04 | 2.69e-03 | 20 |
GO:000920619 | Esophagus | ESCC | purine ribonucleoside triphosphate biosynthetic process | 45/8552 | 68/18723 | 5.13e-04 | 2.84e-03 | 45 |
GO:005067817 | Esophagus | ESCC | regulation of epithelial cell proliferation | 206/8552 | 381/18723 | 5.51e-04 | 3.02e-03 | 206 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:00725273 | Esophagus | ESCC | pyrimidine-containing compound metabolic process | 52/8552 | 82/18723 | 9.03e-04 | 4.61e-03 | 52 |
GO:0045637111 | Esophagus | ESCC | regulation of myeloid cell differentiation | 118/8552 | 210/18723 | 1.35e-03 | 6.43e-03 | 118 |
GO:190210510 | Esophagus | ESCC | regulation of leukocyte differentiation | 152/8552 | 279/18723 | 1.82e-03 | 8.35e-03 | 152 |
GO:004693919 | Esophagus | ESCC | nucleotide phosphorylation | 61/8552 | 101/18723 | 2.03e-03 | 9.08e-03 | 61 |
GO:00456167 | Esophagus | ESCC | regulation of keratinocyte differentiation | 26/8552 | 37/18723 | 2.16e-03 | 9.62e-03 | 26 |
GO:00456841 | Esophagus | ESCC | positive regulation of epidermis development | 23/8552 | 32/18723 | 2.43e-03 | 1.06e-02 | 23 |
GO:200004513 | Esophagus | ESCC | regulation of G1/S transition of mitotic cell cycle | 82/8552 | 142/18723 | 2.49e-03 | 1.08e-02 | 82 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00620 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa006201 | Colorectum | AD | Pyruvate metabolism | 28/2092 | 47/8465 | 3.71e-07 | 5.41e-06 | 3.45e-06 | 28 |
hsa012006 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
hsa006206 | Colorectum | FAP | Pyruvate metabolism | 17/1404 | 47/8465 | 9.18e-04 | 5.20e-03 | 3.16e-03 | 17 |
hsa012007 | Colorectum | FAP | Carbon metabolism | 38/1404 | 115/8465 | 1.04e-05 | 1.44e-04 | 8.76e-05 | 38 |
hsa006207 | Colorectum | FAP | Pyruvate metabolism | 17/1404 | 47/8465 | 9.18e-04 | 5.20e-03 | 3.16e-03 | 17 |
hsa012008 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa012009 | Colorectum | CRC | Carbon metabolism | 28/1091 | 115/8465 | 5.43e-04 | 5.48e-03 | 3.72e-03 | 28 |
hsa0120023 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0062023 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa0120033 | Esophagus | ESCC | Carbon metabolism | 79/4205 | 115/8465 | 2.50e-05 | 1.21e-04 | 6.22e-05 | 79 |
hsa0062033 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa0120041 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0062021 | Liver | HCC | Pyruvate metabolism | 37/4020 | 47/8465 | 1.10e-05 | 8.03e-05 | 4.46e-05 | 37 |
hsa0120051 | Liver | HCC | Carbon metabolism | 89/4020 | 115/8465 | 3.92e-11 | 6.56e-10 | 3.65e-10 | 89 |
hsa0062031 | Liver | HCC | Pyruvate metabolism | 37/4020 | 47/8465 | 1.10e-05 | 8.03e-05 | 4.46e-05 | 37 |
hsa0120014 | Oral cavity | OSCC | Carbon metabolism | 74/3704 | 115/8465 | 6.10e-06 | 3.05e-05 | 1.55e-05 | 74 |
hsa006209 | Oral cavity | OSCC | Pyruvate metabolism | 31/3704 | 47/8465 | 1.74e-03 | 4.73e-03 | 2.41e-03 | 31 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ME2 | SNV | Missense_Mutation | c.985G>C | p.Glu329Gln | p.E329Q | P23368 | protein_coding | tolerated(0.24) | benign(0.045) | TCGA-AR-A0TT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ME2 | SNV | Missense_Mutation | c.1312G>C | p.Glu438Gln | p.E438Q | P23368 | protein_coding | tolerated(0.34) | benign(0.009) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ME2 | SNV | Missense_Mutation | c.1722A>T | p.Glu574Asp | p.E574D | P23368 | protein_coding | tolerated(0.15) | benign(0.006) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
ME2 | SNV | Missense_Mutation | rs777347174 | c.437N>C | p.Ile146Thr | p.I146T | P23368 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ME2 | SNV | Missense_Mutation | c.1099C>T | p.His367Tyr | p.H367Y | P23368 | protein_coding | deleterious(0.04) | probably_damaging(0.987) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
ME2 | SNV | Missense_Mutation | rs766432811 | c.763G>A | p.Glu255Lys | p.E255K | P23368 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ME2 | SNV | Missense_Mutation | c.1222N>A | p.Ala408Thr | p.A408T | P23368 | protein_coding | deleterious(0.05) | possibly_damaging(0.555) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ME2 | SNV | Missense_Mutation | c.79N>T | p.Pro27Ser | p.P27S | P23368 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ME2 | SNV | Missense_Mutation | novel | c.733N>G | p.Arg245Gly | p.R245G | P23368 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ME2 | SNV | Missense_Mutation | c.1014N>C | p.Gln338His | p.Q338H | P23368 | protein_coding | tolerated(0.49) | benign(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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