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Gene: ARL2 |
Gene summary for ARL2 |
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Gene information | Species | Human | Gene symbol | ARL2 | Gene ID | 402 |
Gene name | ADP ribosylation factor like GTPase 2 | |
Gene Alias | ARFL2 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P36404 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
402 | ARL2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.30e-05 | 1.28e-01 | 0.0155 |
402 | ARL2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.65e-07 | 2.15e-01 | -0.1808 |
402 | ARL2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.59e-07 | 2.21e-01 | -0.0811 |
402 | ARL2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.35e-06 | 1.98e-01 | -0.1088 |
402 | ARL2 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.42e-16 | 3.08e-01 | -0.1954 |
402 | ARL2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.29e-05 | 3.67e-01 | -0.2196 |
402 | ARL2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.09e-06 | 2.67e-01 | -0.1207 |
402 | ARL2 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.74e-08 | 2.58e-01 | -0.1526 |
402 | ARL2 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.11e-14 | 2.80e-01 | -0.1464 |
402 | ARL2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-07 | 1.97e-01 | -0.1001 |
402 | ARL2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.53e-17 | 4.04e-01 | -0.059 |
402 | ARL2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.31e-08 | 4.22e-01 | -0.1706 |
402 | ARL2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.12e-05 | 3.01e-01 | -0.2061 |
402 | ARL2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.34e-04 | 2.80e-01 | -0.1462 |
402 | ARL2 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-08 | 3.04e-01 | -0.0842 |
402 | ARL2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.77e-13 | 3.19e-01 | 0.096 |
402 | ARL2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.03e-05 | 4.36e-01 | 0.0451 |
402 | ARL2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.49e-06 | 2.87e-01 | 0.0528 |
402 | ARL2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-08 | 4.07e-01 | 0.0131 |
402 | ARL2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.46e-06 | 2.63e-01 | -0.0177 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005125825 | Oral cavity | EOLP | protein polymerization | 74/2218 | 297/18723 | 2.65e-10 | 2.45e-08 | 74 |
GO:003450422 | Oral cavity | EOLP | protein localization to nucleus | 72/2218 | 290/18723 | 5.47e-10 | 4.31e-08 | 72 |
GO:190290525 | Oral cavity | EOLP | positive regulation of supramolecular fiber organization | 57/2218 | 209/18723 | 8.27e-10 | 6.12e-08 | 57 |
GO:003158925 | Oral cavity | EOLP | cell-substrate adhesion | 84/2218 | 363/18723 | 8.71e-10 | 6.29e-08 | 84 |
GO:004578526 | Oral cavity | EOLP | positive regulation of cell adhesion | 95/2218 | 437/18723 | 2.30e-09 | 1.47e-07 | 95 |
GO:004603426 | Oral cavity | EOLP | ATP metabolic process | 68/2218 | 277/18723 | 2.72e-09 | 1.71e-07 | 68 |
GO:003227325 | Oral cavity | EOLP | positive regulation of protein polymerization | 42/2218 | 138/18723 | 4.07e-09 | 2.39e-07 | 42 |
GO:001081025 | Oral cavity | EOLP | regulation of cell-substrate adhesion | 57/2218 | 221/18723 | 7.77e-09 | 3.94e-07 | 57 |
GO:005123525 | Oral cavity | EOLP | maintenance of location | 75/2218 | 327/18723 | 1.04e-08 | 4.98e-07 | 75 |
GO:005165125 | Oral cavity | EOLP | maintenance of location in cell | 54/2218 | 214/18723 | 4.26e-08 | 1.64e-06 | 54 |
GO:005149524 | Oral cavity | EOLP | positive regulation of cytoskeleton organization | 55/2218 | 226/18723 | 1.19e-07 | 3.99e-06 | 55 |
GO:003111621 | Oral cavity | EOLP | positive regulation of microtubule polymerization | 15/2218 | 33/18723 | 1.55e-06 | 3.65e-05 | 15 |
GO:004518522 | Oral cavity | EOLP | maintenance of protein location | 28/2218 | 94/18723 | 2.44e-06 | 5.45e-05 | 28 |
GO:003250724 | Oral cavity | EOLP | maintenance of protein location in cell | 22/2218 | 65/18723 | 2.82e-06 | 6.18e-05 | 22 |
GO:0010811110 | Oral cavity | EOLP | positive regulation of cell-substrate adhesion | 33/2218 | 123/18723 | 4.19e-06 | 8.76e-05 | 33 |
GO:003111221 | Oral cavity | EOLP | positive regulation of microtubule polymerization or depolymerization | 15/2218 | 37/18723 | 8.82e-06 | 1.65e-04 | 15 |
GO:003111321 | Oral cavity | EOLP | regulation of microtubule polymerization | 18/2218 | 55/18723 | 3.72e-05 | 5.14e-04 | 18 |
GO:004678521 | Oral cavity | EOLP | microtubule polymerization | 23/2218 | 83/18723 | 6.67e-05 | 8.27e-04 | 23 |
GO:004308714 | Oral cavity | EOLP | regulation of GTPase activity | 66/2218 | 348/18723 | 6.92e-05 | 8.55e-04 | 66 |
GO:005134625 | Oral cavity | EOLP | negative regulation of hydrolase activity | 70/2218 | 379/18723 | 9.98e-05 | 1.14e-03 | 70 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL2 | SNV | Missense_Mutation | c.221G>T | p.Arg74Leu | p.R74L | P36404 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A0YE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Taxotere | SD | |
ARL2 | SNV | Missense_Mutation | rs766982672 | c.280G>A | p.Ala94Thr | p.A94T | P36404 | protein_coding | tolerated(0.64) | benign(0.011) | TCGA-C5-A1BF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ARL2 | SNV | Missense_Mutation | rs146832019 | c.443G>A | p.Arg148His | p.R148H | P36404 | protein_coding | deleterious(0.04) | benign(0.001) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARL2 | SNV | Missense_Mutation | c.409N>A | p.Ala137Thr | p.A137T | P36404 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL2 | SNV | Missense_Mutation | rs746518542 | c.124G>A | p.Asp42Asn | p.D42N | P36404 | protein_coding | tolerated(0.47) | benign(0.007) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ARL2 | SNV | Missense_Mutation | novel | c.140C>T | p.Thr47Met | p.T47M | P36404 | protein_coding | deleterious(0.02) | probably_damaging(0.941) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
ARL2 | SNV | Missense_Mutation | rs748651201 | c.221N>A | p.Arg74Gln | p.R74Q | P36404 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AJ-A8CV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL2 | SNV | Missense_Mutation | rs778402408 | c.310N>T | p.Arg104Trp | p.R104W | P36404 | protein_coding | deleterious(0.02) | benign(0.022) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL2 | SNV | Missense_Mutation | rs758628032 | c.475G>A | p.Ala159Thr | p.A159T | P36404 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
ARL2 | SNV | Missense_Mutation | rs779164260 | c.394G>A | p.Ala132Thr | p.A132T | P36404 | protein_coding | deleterious(0) | possibly_damaging(0.903) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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