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Gene: TF |
Gene summary for TF |
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Gene information | Species | Human | Gene symbol | TF | Gene ID | 7018 |
Gene name | transferrin | |
Gene Alias | HEL-S-71p | |
Cytomap | 3q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | A0PJA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7018 | TF | P8T-E | Human | Esophagus | ESCC | 1.25e-10 | 4.06e-01 | 0.0889 |
7018 | TF | P10T-E | Human | Esophagus | ESCC | 1.42e-06 | -5.41e-02 | 0.116 |
7018 | TF | P16T-E | Human | Esophagus | ESCC | 1.60e-16 | 2.50e-01 | 0.1153 |
7018 | TF | P22T-E | Human | Esophagus | ESCC | 2.40e-03 | -8.78e-02 | 0.1236 |
7018 | TF | P57T-E | Human | Esophagus | ESCC | 9.24e-21 | 1.12e+00 | 0.0926 |
7018 | TF | P74T-E | Human | Esophagus | ESCC | 2.85e-03 | 1.43e-01 | 0.1479 |
7018 | TF | P76T-E | Human | Esophagus | ESCC | 5.67e-12 | 8.38e-01 | 0.1207 |
7018 | TF | P128T-E | Human | Esophagus | ESCC | 5.02e-19 | 1.31e+00 | 0.1241 |
7018 | TF | NAFLD1 | Human | Liver | NAFLD | 1.33e-14 | 1.52e+00 | -0.04 |
7018 | TF | S43 | Human | Liver | Cirrhotic | 1.96e-06 | 4.81e-01 | -0.0187 |
7018 | TF | HCC1_Meng | Human | Liver | HCC | 7.28e-77 | 1.16e+00 | 0.0246 |
7018 | TF | HCC2_Meng | Human | Liver | HCC | 6.25e-19 | -6.79e-01 | 0.0107 |
7018 | TF | cirrhotic1 | Human | Liver | Cirrhotic | 3.69e-15 | -1.70e-01 | 0.0202 |
7018 | TF | cirrhotic2 | Human | Liver | Cirrhotic | 1.67e-15 | -1.87e-01 | 0.0201 |
7018 | TF | cirrhotic3 | Human | Liver | Cirrhotic | 2.61e-02 | -4.09e-01 | 0.0215 |
7018 | TF | HCC1 | Human | Liver | HCC | 7.61e-40 | 8.09e+00 | 0.5336 |
7018 | TF | HCC2 | Human | Liver | HCC | 6.48e-53 | 8.08e+00 | 0.5341 |
7018 | TF | HCC5 | Human | Liver | HCC | 3.83e-07 | 4.78e+00 | 0.4932 |
7018 | TF | Pt13.a | Human | Liver | HCC | 1.44e-27 | 2.57e-01 | 0.021 |
7018 | TF | Pt13.b | Human | Liver | HCC | 8.21e-34 | 3.51e-02 | 0.0251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004563711 | Stomach | CAG with IM | regulation of myeloid cell differentiation | 28/1050 | 210/18723 | 1.84e-05 | 5.64e-04 | 28 |
GO:190370611 | Stomach | CAG with IM | regulation of hemopoiesis | 41/1050 | 367/18723 | 2.08e-05 | 6.09e-04 | 41 |
GO:003596711 | Stomach | CAG with IM | cellular response to topologically incorrect protein | 19/1050 | 116/18723 | 2.34e-05 | 6.67e-04 | 19 |
GO:001907911 | Stomach | CAG with IM | viral genome replication | 20/1050 | 131/18723 | 4.12e-05 | 1.10e-03 | 20 |
GO:003166711 | Stomach | CAG with IM | response to nutrient levels | 48/1050 | 474/18723 | 5.51e-05 | 1.38e-03 | 48 |
GO:00022371 | Stomach | CAG with IM | response to molecule of bacterial origin | 39/1050 | 363/18723 | 7.73e-05 | 1.82e-03 | 39 |
GO:00197311 | Stomach | CAG with IM | antibacterial humoral response | 12/1050 | 60/18723 | 1.04e-04 | 2.28e-03 | 12 |
GO:005079211 | Stomach | CAG with IM | regulation of viral process | 22/1050 | 164/18723 | 1.28e-04 | 2.64e-03 | 22 |
GO:004362011 | Stomach | CAG with IM | regulation of DNA-templated transcription in response to stress | 11/1050 | 53/18723 | 1.42e-04 | 2.86e-03 | 11 |
GO:004312211 | Stomach | CAG with IM | regulation of I-kappaB kinase/NF-kappaB signaling | 29/1050 | 249/18723 | 1.58e-04 | 3.07e-03 | 29 |
GO:00086251 | Stomach | CAG with IM | extrinsic apoptotic signaling pathway via death domain receptors | 14/1050 | 82/18723 | 1.72e-04 | 3.30e-03 | 14 |
GO:00026831 | Stomach | CAG with IM | negative regulation of immune system process | 43/1050 | 434/18723 | 2.14e-04 | 3.94e-03 | 43 |
GO:003009911 | Stomach | CAG with IM | myeloid cell differentiation | 39/1050 | 381/18723 | 2.14e-04 | 3.94e-03 | 39 |
GO:004361811 | Stomach | CAG with IM | regulation of transcription from RNA polymerase II promoter in response to stress | 10/1050 | 47/18723 | 2.28e-04 | 4.15e-03 | 10 |
GO:190390011 | Stomach | CAG with IM | regulation of viral life cycle | 20/1050 | 148/18723 | 2.31e-04 | 4.18e-03 | 20 |
GO:200011711 | Stomach | CAG with IM | negative regulation of cysteine-type endopeptidase activity | 14/1050 | 86/18723 | 2.88e-04 | 4.99e-03 | 14 |
GO:19020411 | Stomach | CAG with IM | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 10/1050 | 49/18723 | 3.27e-04 | 5.39e-03 | 10 |
GO:00324961 | Stomach | CAG with IM | response to lipopolysaccharide | 35/1050 | 343/18723 | 4.68e-04 | 7.13e-03 | 35 |
GO:19021051 | Stomach | CAG with IM | regulation of leukocyte differentiation | 30/1050 | 279/18723 | 4.91e-04 | 7.43e-03 | 30 |
GO:19021061 | Stomach | CAG with IM | negative regulation of leukocyte differentiation | 15/1050 | 102/18723 | 5.49e-04 | 8.15e-03 | 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0406629 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa04066113 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0421621 | Liver | Cirrhotic | Ferroptosis | 23/2530 | 41/8465 | 4.09e-04 | 2.57e-03 | 1.58e-03 | 23 |
hsa0406612 | Liver | Cirrhotic | HIF-1 signaling pathway | 46/2530 | 109/8465 | 4.00e-03 | 1.59e-02 | 9.78e-03 | 46 |
hsa0421631 | Liver | Cirrhotic | Ferroptosis | 23/2530 | 41/8465 | 4.09e-04 | 2.57e-03 | 1.58e-03 | 23 |
hsa0406613 | Liver | Cirrhotic | HIF-1 signaling pathway | 46/2530 | 109/8465 | 4.00e-03 | 1.59e-02 | 9.78e-03 | 46 |
hsa0421641 | Liver | HCC | Ferroptosis | 33/4020 | 41/8465 | 1.42e-05 | 9.88e-05 | 5.50e-05 | 33 |
hsa0406622 | Liver | HCC | HIF-1 signaling pathway | 70/4020 | 109/8465 | 2.96e-04 | 1.36e-03 | 7.57e-04 | 70 |
hsa0421651 | Liver | HCC | Ferroptosis | 33/4020 | 41/8465 | 1.42e-05 | 9.88e-05 | 5.50e-05 | 33 |
hsa0406632 | Liver | HCC | HIF-1 signaling pathway | 70/4020 | 109/8465 | 2.96e-04 | 1.36e-03 | 7.57e-04 | 70 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TF | SNV | Missense_Mutation | c.1906N>T | p.Gly636Cys | p.G636C | P02787 | protein_coding | deleterious(0.01) | possibly_damaging(0.767) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
TF | SNV | Missense_Mutation | novel | c.693N>T | p.Glu231Asp | p.E231D | P02787 | protein_coding | tolerated(0.09) | benign(0.138) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TF | SNV | Missense_Mutation | c.1009N>C | p.Glu337Gln | p.E337Q | P02787 | protein_coding | tolerated(0.24) | benign(0.03) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TF | SNV | Missense_Mutation | c.1565N>C | p.Leu522Pro | p.L522P | P02787 | protein_coding | tolerated(0.35) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
TF | SNV | Missense_Mutation | novel | c.1816N>C | p.Val606Leu | p.V606L | P02787 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TF | SNV | Missense_Mutation | novel | c.1073G>T | p.Cys358Phe | p.C358F | P02787 | protein_coding | deleterious(0.05) | benign(0.097) | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
TF | SNV | Missense_Mutation | novel | c.161N>T | p.Pro54Leu | p.P54L | P02787 | protein_coding | tolerated(0.06) | possibly_damaging(0.843) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TF | SNV | Missense_Mutation | c.1907N>T | p.Gly636Val | p.G636V | P02787 | protein_coding | tolerated(0.05) | benign(0.375) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TF | SNV | Missense_Mutation | c.493C>G | p.Leu165Val | p.L165V | P02787 | protein_coding | tolerated(0.45) | benign(0.035) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
TF | insertion | Frame_Shift_Ins | novel | c.2011_2012insCCTCTGGGGGAACAACCACTCA | p.Gly671AlafsTer17 | p.G671Afs*17 | P02787 | protein_coding | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | adalimumab | ADALIMUMAB | 27115882 | |
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | Ademetionine | ADEMETIONINE | ||
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | CALAA-01 | |||
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | PF-06763809 | |||
7018 | TF | CELL SURFACE, DRUGGABLE GENOME | EP-2167 |
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