GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004259312 | Liver | Cirrhotic | glucose homeostasis | 86/4634 | 258/18723 | 1.12e-03 | 7.73e-03 | 86 |
GO:00713316 | Liver | Cirrhotic | cellular response to hexose stimulus | 55/4634 | 153/18723 | 1.27e-03 | 8.56e-03 | 55 |
GO:003350012 | Liver | Cirrhotic | carbohydrate homeostasis | 86/4634 | 259/18723 | 1.28e-03 | 8.61e-03 | 86 |
GO:00713266 | Liver | Cirrhotic | cellular response to monosaccharide stimulus | 55/4634 | 154/18723 | 1.51e-03 | 9.91e-03 | 55 |
GO:000614011 | Liver | Cirrhotic | regulation of nucleotide metabolic process | 34/4634 | 86/18723 | 1.71e-03 | 1.09e-02 | 34 |
GO:00713226 | Liver | Cirrhotic | cellular response to carbohydrate stimulus | 57/4634 | 163/18723 | 2.18e-03 | 1.34e-02 | 57 |
GO:19005423 | Liver | Cirrhotic | regulation of purine nucleotide metabolic process | 32/4634 | 84/18723 | 4.53e-03 | 2.40e-02 | 32 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:000989622 | Liver | HCC | positive regulation of catabolic process | 335/7958 | 492/18723 | 3.83e-31 | 1.87e-28 | 335 |
GO:003133122 | Liver | HCC | positive regulation of cellular catabolic process | 295/7958 | 427/18723 | 3.20e-29 | 1.45e-26 | 295 |
GO:004603422 | Liver | HCC | ATP metabolic process | 198/7958 | 277/18723 | 8.30e-23 | 1.55e-20 | 198 |
GO:000911722 | Liver | HCC | nucleotide metabolic process | 300/7958 | 489/18723 | 1.61e-17 | 1.71e-15 | 300 |
GO:000675322 | Liver | HCC | nucleoside phosphate metabolic process | 304/7958 | 497/18723 | 1.78e-17 | 1.85e-15 | 304 |
GO:001969322 | Liver | HCC | ribose phosphate metabolic process | 248/7958 | 396/18723 | 3.15e-16 | 2.70e-14 | 248 |
GO:000925922 | Liver | HCC | ribonucleotide metabolic process | 240/7958 | 385/18723 | 2.07e-15 | 1.51e-13 | 240 |
GO:000915022 | Liver | HCC | purine ribonucleotide metabolic process | 226/7958 | 368/18723 | 1.36e-13 | 7.69e-12 | 226 |
GO:007252122 | Liver | HCC | purine-containing compound metabolic process | 250/7958 | 416/18723 | 2.26e-13 | 1.24e-11 | 250 |
GO:000616322 | Liver | HCC | purine nucleotide metabolic process | 236/7958 | 396/18723 | 3.59e-12 | 1.62e-10 | 236 |
GO:004346722 | Liver | HCC | regulation of generation of precursor metabolites and energy | 89/7958 | 130/18723 | 1.84e-09 | 5.35e-08 | 89 |
GO:000609022 | Liver | HCC | pyruvate metabolic process | 73/7958 | 106/18723 | 3.52e-08 | 7.82e-07 | 73 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB2 | SNV | Missense_Mutation | | c.764N>T | p.Ala255Val | p.A255V | Q8N680 | protein_coding | tolerated(0.98) | benign(0.07) | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB2 | SNV | Missense_Mutation | | c.233N>G | p.His78Arg | p.H78R | Q8N680 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-AR-A1AW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
ZBTB2 | SNV | Missense_Mutation | | c.406C>G | p.Gln136Glu | p.Q136E | Q8N680 | protein_coding | deleterious(0) | possibly_damaging(0.622) | TCGA-BH-A0C0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZBTB2 | SNV | Missense_Mutation | | c.239N>A | p.Met80Lys | p.M80K | Q8N680 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-D8-A1XZ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen+anastrozolum | SD |
ZBTB2 | SNV | Missense_Mutation | | c.629N>G | p.Pro210Arg | p.P210R | Q8N680 | protein_coding | tolerated(0.58) | benign(0.044) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZBTB2 | SNV | Missense_Mutation | | c.28N>G | p.Leu10Val | p.L10V | Q8N680 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
ZBTB2 | insertion | Frame_Shift_Ins | novel | c.823_824insCGAAGGGCGATCCATTCTCCTGGGC | p.Ile275ThrfsTer18 | p.I275Tfs*18 | Q8N680 | protein_coding | | | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
ZBTB2 | SNV | Missense_Mutation | | c.602N>T | p.Ser201Leu | p.S201L | Q8N680 | protein_coding | tolerated(0.22) | benign(0.144) | TCGA-EA-A439-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ZBTB2 | SNV | Missense_Mutation | rs762417728 | c.635C>T | p.Pro212Leu | p.P212L | Q8N680 | protein_coding | tolerated(0.33) | benign(0.025) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
ZBTB2 | SNV | Missense_Mutation | rs191541534 | c.340N>A | p.Ala114Thr | p.A114T | Q8N680 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-DM-A28H-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |