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Gene: SUN2 |
Gene summary for SUN2 |
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Gene information | Species | Human | Gene symbol | SUN2 | Gene ID | 25777 |
Gene name | Sad1 and UNC84 domain containing 2 | |
Gene Alias | UNC84B | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4E2A6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25777 | SUN2 | LZE2T | Human | Esophagus | ESCC | 2.61e-06 | 5.79e-01 | 0.082 |
25777 | SUN2 | LZE4T | Human | Esophagus | ESCC | 2.56e-08 | 2.42e-02 | 0.0811 |
25777 | SUN2 | LZE7T | Human | Esophagus | ESCC | 2.43e-04 | 1.08e-01 | 0.0667 |
25777 | SUN2 | LZE20T | Human | Esophagus | ESCC | 6.89e-04 | 1.13e-01 | 0.0662 |
25777 | SUN2 | LZE24T | Human | Esophagus | ESCC | 9.03e-07 | -1.59e-02 | 0.0596 |
25777 | SUN2 | LZE6T | Human | Esophagus | ESCC | 4.84e-02 | 1.35e-02 | 0.0845 |
25777 | SUN2 | P1T-E | Human | Esophagus | ESCC | 1.58e-11 | 7.04e-01 | 0.0875 |
25777 | SUN2 | P2T-E | Human | Esophagus | ESCC | 4.77e-16 | 5.14e-01 | 0.1177 |
25777 | SUN2 | P4T-E | Human | Esophagus | ESCC | 8.63e-17 | 3.91e-01 | 0.1323 |
25777 | SUN2 | P8T-E | Human | Esophagus | ESCC | 3.61e-21 | 3.94e-01 | 0.0889 |
25777 | SUN2 | P9T-E | Human | Esophagus | ESCC | 1.34e-06 | 1.26e-01 | 0.1131 |
25777 | SUN2 | P10T-E | Human | Esophagus | ESCC | 1.12e-07 | 6.63e-01 | 0.116 |
25777 | SUN2 | P11T-E | Human | Esophagus | ESCC | 1.24e-18 | 6.59e-01 | 0.1426 |
25777 | SUN2 | P12T-E | Human | Esophagus | ESCC | 2.50e-21 | 3.02e-01 | 0.1122 |
25777 | SUN2 | P15T-E | Human | Esophagus | ESCC | 4.87e-19 | 6.97e-01 | 0.1149 |
25777 | SUN2 | P16T-E | Human | Esophagus | ESCC | 3.18e-21 | 6.68e-01 | 0.1153 |
25777 | SUN2 | P17T-E | Human | Esophagus | ESCC | 2.99e-09 | 5.22e-01 | 0.1278 |
25777 | SUN2 | P19T-E | Human | Esophagus | ESCC | 1.09e-09 | 6.77e-01 | 0.1662 |
25777 | SUN2 | P20T-E | Human | Esophagus | ESCC | 1.63e-11 | 1.55e-01 | 0.1124 |
25777 | SUN2 | P21T-E | Human | Esophagus | ESCC | 1.35e-26 | 7.52e-01 | 0.1617 |
Page: 1 2 3 4 5 6 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
GO:1902369110 | Thyroid | PTC | negative regulation of RNA catabolic process | 38/5968 | 75/18723 | 5.41e-04 | 3.47e-03 | 38 |
GO:19019885 | Thyroid | PTC | negative regulation of cell cycle phase transition | 104/5968 | 249/18723 | 6.01e-04 | 3.82e-03 | 104 |
GO:006184210 | Thyroid | PTC | microtubule organizing center localization | 20/5968 | 33/18723 | 6.26e-04 | 3.96e-03 | 20 |
GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
GO:009951517 | Thyroid | PTC | actin filament-based transport | 14/5968 | 21/18723 | 1.11e-03 | 6.51e-03 | 14 |
GO:005164210 | Thyroid | PTC | centrosome localization | 19/5968 | 32/18723 | 1.21e-03 | 6.94e-03 | 19 |
GO:004206315 | Thyroid | PTC | gliogenesis | 121/5968 | 301/18723 | 1.30e-03 | 7.41e-03 | 121 |
GO:00000756 | Thyroid | PTC | cell cycle checkpoint | 72/5968 | 169/18723 | 2.09e-03 | 1.11e-02 | 72 |
GO:00215438 | Thyroid | PTC | pallium development | 72/5968 | 169/18723 | 2.09e-03 | 1.11e-02 | 72 |
GO:004886318 | Thyroid | PTC | stem cell differentiation | 85/5968 | 206/18723 | 2.71e-03 | 1.36e-02 | 85 |
GO:00215373 | Thyroid | PTC | telencephalon development | 100/5968 | 248/18723 | 2.90e-03 | 1.44e-02 | 100 |
GO:00083471 | Thyroid | PTC | glial cell migration | 27/5968 | 53/18723 | 2.98e-03 | 1.47e-02 | 27 |
GO:002198713 | Thyroid | PTC | cerebral cortex development | 50/5968 | 114/18723 | 4.71e-03 | 2.21e-02 | 50 |
GO:00218011 | Thyroid | PTC | cerebral cortex radial glia guided migration | 14/5968 | 24/18723 | 6.65e-03 | 2.89e-02 | 14 |
GO:00220301 | Thyroid | PTC | telencephalon glial cell migration | 14/5968 | 24/18723 | 6.65e-03 | 2.89e-02 | 14 |
GO:00309007 | Thyroid | PTC | forebrain development | 143/5968 | 379/18723 | 8.47e-03 | 3.56e-02 | 143 |
GO:000709710 | Thyroid | PTC | nuclear migration | 12/5968 | 20/18723 | 8.78e-03 | 3.66e-02 | 12 |
GO:004348916 | Thyroid | PTC | RNA stabilization | 30/5968 | 65/18723 | 1.11e-02 | 4.42e-02 | 30 |
GO:003238632 | Thyroid | ATC | regulation of intracellular transport | 203/6293 | 337/18723 | 6.16e-24 | 1.85e-21 | 203 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUN2 | SNV | Missense_Mutation | c.1171T>A | p.Ser391Thr | p.S391T | Q9UH99 | protein_coding | tolerated(0.39) | benign(0.014) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
SUN2 | SNV | Missense_Mutation | rs142901119 | c.1106N>A | p.Arg369His | p.R369H | Q9UH99 | protein_coding | tolerated(0.15) | benign(0.033) | TCGA-WT-AB44-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
SUN2 | SNV | Missense_Mutation | c.2203N>A | p.Glu735Lys | p.E735K | Q9UH99 | protein_coding | deleterious(0) | benign(0.151) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
SUN2 | SNV | Missense_Mutation | c.686N>T | p.Ser229Leu | p.S229L | Q9UH99 | protein_coding | tolerated(0.41) | benign(0.21) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SUN2 | SNV | Missense_Mutation | rs142753729 | c.277N>A | p.Ala93Thr | p.A93T | Q9UH99 | protein_coding | tolerated(0.73) | benign(0.026) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SUN2 | SNV | Missense_Mutation | c.481C>A | p.Pro161Thr | p.P161T | Q9UH99 | protein_coding | tolerated(0.57) | benign(0.051) | TCGA-WL-A834-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
SUN2 | SNV | Missense_Mutation | rs145042745 | c.661N>A | p.Val221Ile | p.V221I | Q9UH99 | protein_coding | deleterious(0.01) | probably_damaging(0.945) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SUN2 | SNV | Missense_Mutation | rs752409009 | c.734N>T | p.Thr245Met | p.T245M | Q9UH99 | protein_coding | deleterious(0.02) | possibly_damaging(0.742) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SUN2 | SNV | Missense_Mutation | rs752150588 | c.1775N>T | p.Thr592Met | p.T592M | Q9UH99 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SUN2 | SNV | Missense_Mutation | c.2023N>T | p.Asp675Tyr | p.D675Y | Q9UH99 | protein_coding | deleterious(0) | possibly_damaging(0.725) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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