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Gene: SKI |
Gene summary for SKI |
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Gene information | Species | Human | Gene symbol | SKI | Gene ID | 6497 |
Gene name | SKI proto-oncogene | |
Gene Alias | SGS | |
Cytomap | 1p36.33-p36.32 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P12755 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6497 | SKI | LZE7T | Human | Esophagus | ESCC | 2.91e-05 | 2.53e-02 | 0.0667 |
6497 | SKI | LZE8T | Human | Esophagus | ESCC | 3.04e-06 | -2.10e-02 | 0.067 |
6497 | SKI | LZE24D1 | Human | Esophagus | HGIN | 1.88e-03 | 3.97e-01 | 0.054 |
6497 | SKI | LZE24T | Human | Esophagus | ESCC | 7.94e-05 | 6.44e-02 | 0.0596 |
6497 | SKI | P1T-E | Human | Esophagus | ESCC | 2.62e-04 | 5.29e-02 | 0.0875 |
6497 | SKI | P2T-E | Human | Esophagus | ESCC | 1.00e-14 | 2.93e-01 | 0.1177 |
6497 | SKI | P4T-E | Human | Esophagus | ESCC | 1.79e-06 | 1.46e-01 | 0.1323 |
6497 | SKI | P5T-E | Human | Esophagus | ESCC | 1.27e-12 | -3.21e-02 | 0.1327 |
6497 | SKI | P8T-E | Human | Esophagus | ESCC | 1.12e-18 | 4.26e-01 | 0.0889 |
6497 | SKI | P9T-E | Human | Esophagus | ESCC | 1.37e-10 | 2.68e-02 | 0.1131 |
6497 | SKI | P10T-E | Human | Esophagus | ESCC | 2.55e-11 | 3.13e-01 | 0.116 |
6497 | SKI | P11T-E | Human | Esophagus | ESCC | 6.32e-11 | 9.20e-02 | 0.1426 |
6497 | SKI | P12T-E | Human | Esophagus | ESCC | 7.72e-10 | 2.74e-01 | 0.1122 |
6497 | SKI | P15T-E | Human | Esophagus | ESCC | 8.66e-11 | 1.12e-01 | 0.1149 |
6497 | SKI | P16T-E | Human | Esophagus | ESCC | 9.05e-15 | 1.43e-01 | 0.1153 |
6497 | SKI | P20T-E | Human | Esophagus | ESCC | 5.25e-10 | 4.43e-02 | 0.1124 |
6497 | SKI | P21T-E | Human | Esophagus | ESCC | 4.21e-19 | 1.77e-01 | 0.1617 |
6497 | SKI | P22T-E | Human | Esophagus | ESCC | 1.64e-09 | -8.58e-02 | 0.1236 |
6497 | SKI | P23T-E | Human | Esophagus | ESCC | 2.27e-04 | 1.16e-01 | 0.108 |
6497 | SKI | P24T-E | Human | Esophagus | ESCC | 1.52e-05 | -1.57e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004887218 | Prostate | BPH | homeostasis of number of cells | 79/3107 | 272/18723 | 1.79e-07 | 3.99e-06 | 79 |
GO:00715607 | Prostate | BPH | cellular response to transforming growth factor beta stimulus | 72/3107 | 250/18723 | 8.71e-07 | 1.61e-05 | 72 |
GO:20012448 | Prostate | BPH | positive regulation of intrinsic apoptotic signaling pathway | 25/3107 | 58/18723 | 1.76e-06 | 2.94e-05 | 25 |
GO:00507695 | Prostate | BPH | positive regulation of neurogenesis | 63/3107 | 225/18723 | 1.11e-05 | 1.51e-04 | 63 |
GO:00071797 | Prostate | BPH | transforming growth factor beta receptor signaling pathway | 57/3107 | 198/18723 | 1.17e-05 | 1.58e-04 | 57 |
GO:000863016 | Prostate | BPH | intrinsic apoptotic signaling pathway in response to DNA damage | 34/3107 | 99/18723 | 1.29e-05 | 1.70e-04 | 34 |
GO:190204110 | Prostate | BPH | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 21/3107 | 49/18723 | 1.30e-05 | 1.72e-04 | 21 |
GO:00507678 | Prostate | BPH | regulation of neurogenesis | 92/3107 | 364/18723 | 1.36e-05 | 1.78e-04 | 92 |
GO:00071788 | Prostate | BPH | transmembrane receptor protein serine/threonine kinase signaling pathway | 90/3107 | 355/18723 | 1.48e-05 | 1.90e-04 | 90 |
GO:000862514 | Prostate | BPH | extrinsic apoptotic signaling pathway via death domain receptors | 29/3107 | 82/18723 | 2.92e-05 | 3.34e-04 | 29 |
GO:00615649 | Prostate | BPH | axon development | 111/3107 | 467/18723 | 3.51e-05 | 3.88e-04 | 111 |
GO:200102015 | Prostate | BPH | regulation of response to DNA damage stimulus | 60/3107 | 219/18723 | 3.58e-05 | 3.92e-04 | 60 |
GO:00074099 | Prostate | BPH | axonogenesis | 98/3107 | 418/18723 | 1.68e-04 | 1.45e-03 | 98 |
GO:00519623 | Prostate | BPH | positive regulation of nervous system development | 67/3107 | 272/18723 | 4.15e-04 | 3.01e-03 | 67 |
GO:19038445 | Prostate | BPH | regulation of cellular response to transforming growth factor beta stimulus | 37/3107 | 131/18723 | 5.57e-04 | 3.89e-03 | 37 |
GO:00519604 | Prostate | BPH | regulation of nervous system development | 100/3107 | 443/18723 | 6.02e-04 | 4.16e-03 | 100 |
GO:00170154 | Prostate | BPH | regulation of transforming growth factor beta receptor signaling pathway | 36/3107 | 128/18723 | 7.16e-04 | 4.76e-03 | 36 |
GO:19022296 | Prostate | BPH | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 14/3107 | 36/18723 | 1.16e-03 | 7.17e-03 | 14 |
GO:0090287 | Prostate | BPH | regulation of cellular response to growth factor stimulus | 70/3107 | 304/18723 | 2.18e-03 | 1.21e-02 | 70 |
GO:00507706 | Prostate | BPH | regulation of axonogenesis | 39/3107 | 154/18723 | 3.65e-03 | 1.85e-02 | 39 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SKI | SNV | Missense_Mutation | novel | c.644N>T | p.Glu215Val | p.E215V | P12755 | protein_coding | deleterious(0.02) | possibly_damaging(0.81) | TCGA-OL-A5D6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SKI | SNV | Missense_Mutation | c.1435N>A | p.Asp479Asn | p.D479N | P12755 | protein_coding | tolerated(0.06) | benign(0.011) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
SKI | SNV | Missense_Mutation | novel | c.833N>G | p.Ser278Trp | p.S278W | P12755 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-VS-A8QM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SKI | SNV | Missense_Mutation | rs752151031 | c.1400N>T | p.Thr467Met | p.T467M | P12755 | protein_coding | tolerated(0.15) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
SKI | SNV | Missense_Mutation | c.892G>A | p.Ala298Thr | p.A298T | P12755 | protein_coding | tolerated(0.26) | benign(0.027) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SKI | SNV | Missense_Mutation | c.1670A>T | p.Glu557Val | p.E557V | P12755 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-DC-4749-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SKI | SNV | Missense_Mutation | novel | c.1597N>A | p.Asp533Asn | p.D533N | P12755 | protein_coding | tolerated(0.27) | benign(0.059) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SKI | SNV | Missense_Mutation | novel | c.434A>G | p.Glu145Gly | p.E145G | P12755 | protein_coding | deleterious(0) | possibly_damaging(0.553) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
SKI | SNV | Missense_Mutation | novel | c.1945N>A | p.Val649Met | p.V649M | P12755 | protein_coding | deleterious(0.01) | benign(0.38) | TCGA-AX-A2H4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
SKI | SNV | Missense_Mutation | c.477G>T | p.Glu159Asp | p.E159D | P12755 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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