Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/PPP1CA_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PPP1CA_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PPP1CA_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/PPP1CA_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PPP1CA_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/PPP1CA_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PPP1CA_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PPP1CA_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PPP1CA_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00325355 | Stomach | GC | regulation of cellular component size | 44/1159 | 383/18723 | 5.66e-05 | 1.31e-03 | 44 |
GO:00434675 | Stomach | GC | regulation of generation of precursor metabolites and energy | 20/1159 | 130/18723 | 1.43e-04 | 2.64e-03 | 20 |
GO:00059964 | Stomach | GC | monosaccharide metabolic process | 31/1159 | 257/18723 | 2.90e-04 | 4.67e-03 | 31 |
GO:00193184 | Stomach | GC | hexose metabolic process | 29/1159 | 237/18723 | 3.53e-04 | 5.54e-03 | 29 |
GO:0009314 | Stomach | GC | response to radiation | 47/1159 | 456/18723 | 4.21e-04 | 6.33e-03 | 47 |
GO:00433936 | Stomach | GC | regulation of protein binding | 25/1159 | 196/18723 | 4.72e-04 | 6.84e-03 | 25 |
GO:00160525 | Stomach | GC | carbohydrate catabolic process | 21/1159 | 154/18723 | 5.38e-04 | 7.55e-03 | 21 |
GO:00511005 | Stomach | GC | negative regulation of binding | 21/1159 | 162/18723 | 1.05e-03 | 1.24e-02 | 21 |
GO:00320913 | Stomach | GC | negative regulation of protein binding | 14/1159 | 94/18723 | 1.87e-03 | 1.93e-02 | 14 |
GO:00060064 | Stomach | GC | glucose metabolic process | 23/1159 | 196/18723 | 2.39e-03 | 2.29e-02 | 23 |
GO:2001238 | Stomach | GC | positive regulation of extrinsic apoptotic signaling pathway | 9/1159 | 48/18723 | 2.43e-03 | 2.30e-02 | 9 |
GO:00064176 | Stomach | GC | regulation of translation | 44/1159 | 468/18723 | 3.81e-03 | 3.22e-02 | 44 |
GO:00224116 | Stomach | GC | cellular component disassembly | 42/1159 | 443/18723 | 3.99e-03 | 3.35e-02 | 42 |
GO:0009649 | Stomach | GC | entrainment of circadian clock | 7/1159 | 34/18723 | 4.21e-03 | 3.49e-02 | 7 |
GO:20012353 | Stomach | GC | positive regulation of apoptotic signaling pathway | 16/1159 | 126/18723 | 4.84e-03 | 3.87e-02 | 16 |
GO:00076235 | Stomach | GC | circadian rhythm | 23/1159 | 210/18723 | 5.64e-03 | 4.34e-02 | 23 |
GO:0070873 | Stomach | GC | regulation of glycogen metabolic process | 7/1159 | 36/18723 | 5.87e-03 | 4.44e-02 | 7 |
GO:00380343 | Stomach | GC | signal transduction in absence of ligand | 10/1159 | 65/18723 | 6.34e-03 | 4.73e-02 | 10 |
GO:00971923 | Stomach | GC | extrinsic apoptotic signaling pathway in absence of ligand | 10/1159 | 65/18723 | 6.34e-03 | 4.73e-02 | 10 |
GO:000609111 | Stomach | CAG with IM | generation of precursor metabolites and energy | 86/1050 | 490/18723 | 1.45e-21 | 1.93e-18 | 86 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP1CA | insertion | In_Frame_Ins | novel | c.223_224insGACCCAGAAGCTCCAAGTTAC | p.Asp75delinsGlyProArgSerSerLysLeuHis | p.D75delinsGPRSSKLH | P62136 | protein_coding | | | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1CA | insertion | Frame_Shift_Ins | novel | c.221_222insCGGGAAGATCCCT | p.Asp75GlyfsTer5 | p.D75Gfs*5 | P62136 | protein_coding | | | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1CA | insertion | Frame_Shift_Ins | novel | c.348_349insGGAGT | p.Leu117GlyfsTer61 | p.L117Gfs*61 | P62136 | protein_coding | | | TCGA-BH-A0B9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PPP1CA | insertion | Frame_Shift_Ins | novel | c.347_348insTTTCTTTACTTTTTTGAGA | p.Leu117PhefsTer12 | p.L117Ffs*12 | P62136 | protein_coding | | | TCGA-BH-A0B9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
PPP1CA | deletion | Frame_Shift_Del | novel | c.620delC | p.Pro207LeufsTer56 | p.P207Lfs*56 | P62136 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
PPP1CA | SNV | Missense_Mutation | | c.461N>A | p.Arg154His | p.R154H | P62136 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.966) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP1CA | SNV | Missense_Mutation | novel | c.441N>A | p.Phe147Leu | p.F147L | P62136 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.727) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
PPP1CA | SNV | Missense_Mutation | | c.848N>G | p.Tyr283Cys | p.Y283C | P62136 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(1) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
PPP1CA | SNV | Missense_Mutation | novel | c.379N>A | p.Glu127Lys | p.E127K | P62136 | protein_coding | deleterious_low_confidence(0.01) | benign(0.057) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PPP1CA | SNV | Missense_Mutation | rs774510465 | c.931N>A | p.Asp311Asn | p.D311N | P62136 | protein_coding | deleterious_low_confidence(0.05) | benign(0) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |