Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/PARG_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PARG_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PARG_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PARG_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PARG_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00229004 | Colorectum | FAP | electron transport chain | 51/2622 | 175/18723 | 1.44e-07 | 9.03e-06 | 51 |
GO:00069794 | Colorectum | FAP | response to oxidative stress | 102/2622 | 446/18723 | 2.29e-07 | 1.33e-05 | 102 |
GO:00328683 | Colorectum | FAP | response to insulin | 68/2622 | 264/18723 | 2.71e-07 | 1.55e-05 | 68 |
GO:00485454 | Colorectum | FAP | response to steroid hormone | 81/2622 | 339/18723 | 6.22e-07 | 3.08e-05 | 81 |
GO:00305223 | Colorectum | FAP | intracellular receptor signaling pathway | 67/2622 | 265/18723 | 6.84e-07 | 3.28e-05 | 67 |
GO:00163113 | Colorectum | FAP | dephosphorylation | 95/2622 | 417/18723 | 7.07e-07 | 3.32e-05 | 95 |
GO:00434014 | Colorectum | FAP | steroid hormone mediated signaling pathway | 41/2622 | 136/18723 | 8.82e-07 | 4.03e-05 | 41 |
GO:00076233 | Colorectum | FAP | circadian rhythm | 56/2622 | 210/18723 | 9.12e-07 | 4.14e-05 | 56 |
GO:00510524 | Colorectum | FAP | regulation of DNA metabolic process | 84/2622 | 359/18723 | 9.80e-07 | 4.38e-05 | 84 |
GO:00469394 | Colorectum | FAP | nucleotide phosphorylation | 33/2622 | 101/18723 | 1.40e-06 | 6.17e-05 | 33 |
GO:00328693 | Colorectum | FAP | cellular response to insulin stimulus | 54/2622 | 203/18723 | 1.54e-06 | 6.59e-05 | 54 |
GO:00485113 | Colorectum | FAP | rhythmic process | 72/2622 | 298/18723 | 1.67e-06 | 6.99e-05 | 72 |
GO:00160523 | Colorectum | FAP | carbohydrate catabolic process | 44/2622 | 154/18723 | 1.82e-06 | 7.42e-05 | 44 |
GO:00097554 | Colorectum | FAP | hormone-mediated signaling pathway | 51/2622 | 190/18723 | 2.23e-06 | 8.87e-05 | 51 |
GO:00097434 | Colorectum | FAP | response to carbohydrate | 63/2622 | 253/18723 | 2.52e-06 | 9.77e-05 | 63 |
GO:00510544 | Colorectum | FAP | positive regulation of DNA metabolic process | 53/2622 | 201/18723 | 2.55e-06 | 9.82e-05 | 53 |
GO:00061654 | Colorectum | FAP | nucleoside diphosphate phosphorylation | 32/2622 | 99/18723 | 2.61e-06 | 9.94e-05 | 32 |
GO:00508214 | Colorectum | FAP | protein stabilization | 51/2622 | 191/18723 | 2.63e-06 | 9.96e-05 | 51 |
GO:00229044 | Colorectum | FAP | respiratory electron transport chain | 35/2622 | 114/18723 | 3.43e-06 | 1.23e-04 | 35 |
GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PARG | SNV | Missense_Mutation | novel | c.2006N>T | p.Ser669Leu | p.S669L | Q86W56 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-AQ-A54N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PARG | insertion | Frame_Shift_Ins | novel | c.1451_1452insCT | p.Arg485PhefsTer3 | p.R485Ffs*3 | Q86W56 | protein_coding | | | TCGA-S3-AA11-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | CR |
PARG | SNV | Missense_Mutation | rs4614387 | c.1453N>T | p.Arg485Trp | p.R485W | Q86W56 | protein_coding | deleterious(0) | benign(0.072) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PARG | SNV | Missense_Mutation | novel | c.517N>G | p.Gln173Glu | p.Q173E | Q86W56 | protein_coding | tolerated_low_confidence(0.16) | benign(0.001) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PARG | SNV | Missense_Mutation | novel | c.2515N>C | p.Glu839Gln | p.E839Q | Q86W56 | protein_coding | tolerated(0.06) | benign(0.312) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PARG | SNV | Missense_Mutation | novel | c.815G>A | p.Gly272Asp | p.G272D | Q86W56 | protein_coding | tolerated_low_confidence(0.64) | benign(0.049) | TCGA-VS-A8EB-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | PD |
PARG | SNV | Missense_Mutation | novel | c.1199C>G | p.Ser400Cys | p.S400C | Q86W56 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.628) | TCGA-VS-A8Q8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
PARG | deletion | Frame_Shift_Del | novel | c.2808delN | p.Tyr936Ter | p.Y936* | Q86W56 | protein_coding | | | TCGA-C5-A7X3-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
PARG | SNV | Missense_Mutation | novel | c.2173N>G | p.Thr725Ala | p.T725A | Q86W56 | protein_coding | deleterious(0.02) | benign(0.359) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PARG | SNV | Missense_Mutation | novel | c.1865C>G | p.Ser622Cys | p.S622C | Q86W56 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-AA-3662-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PR |