GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003166917 | Prostate | Tumor | cellular response to nutrient levels | 66/3246 | 215/18723 | 1.00e-06 | 1.94e-05 | 66 |
GO:200123815 | Prostate | Tumor | positive regulation of extrinsic apoptotic signaling pathway | 23/3246 | 48/18723 | 1.02e-06 | 1.96e-05 | 23 |
GO:200124415 | Prostate | Tumor | positive regulation of intrinsic apoptotic signaling pathway | 26/3246 | 58/18723 | 1.03e-06 | 1.99e-05 | 26 |
GO:004328017 | Prostate | Tumor | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 45/3246 | 129/18723 | 1.17e-06 | 2.21e-05 | 45 |
GO:000862515 | Prostate | Tumor | extrinsic apoptotic signaling pathway via death domain receptors | 32/3246 | 82/18723 | 2.65e-06 | 4.44e-05 | 32 |
GO:003033017 | Prostate | Tumor | DNA damage response, signal transduction by p53 class mediator | 29/3246 | 72/18723 | 3.66e-06 | 5.91e-05 | 29 |
GO:000926716 | Prostate | Tumor | cellular response to starvation | 50/3246 | 156/18723 | 5.17e-06 | 8.00e-05 | 50 |
GO:200105617 | Prostate | Tumor | positive regulation of cysteine-type endopeptidase activity | 48/3246 | 148/18723 | 5.51e-06 | 8.48e-05 | 48 |
GO:007145316 | Prostate | Tumor | cellular response to oxygen levels | 54/3246 | 177/18723 | 1.13e-05 | 1.62e-04 | 54 |
GO:004259415 | Prostate | Tumor | response to starvation | 58/3246 | 197/18723 | 1.79e-05 | 2.38e-04 | 58 |
GO:007005918 | Prostate | Tumor | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 25/3246 | 63/18723 | 2.28e-05 | 2.88e-04 | 25 |
GO:190204114 | Prostate | Tumor | regulation of extrinsic apoptotic signaling pathway via death domain receptors | 21/3246 | 49/18723 | 2.59e-05 | 3.18e-04 | 21 |
GO:003629416 | Prostate | Tumor | cellular response to decreased oxygen levels | 49/3246 | 161/18723 | 3.02e-05 | 3.62e-04 | 49 |
GO:000863717 | Prostate | Tumor | apoptotic mitochondrial changes | 36/3246 | 107/18723 | 3.26e-05 | 3.86e-04 | 36 |
GO:001082116 | Prostate | Tumor | regulation of mitochondrion organization | 44/3246 | 144/18723 | 6.75e-05 | 7.21e-04 | 44 |
GO:007145614 | Prostate | Tumor | cellular response to hypoxia | 45/3246 | 151/18723 | 1.08e-04 | 1.03e-03 | 45 |
GO:000600613 | Prostate | Tumor | glucose metabolic process | 55/3246 | 196/18723 | 1.22e-04 | 1.14e-03 | 55 |
GO:004277012 | Prostate | Tumor | signal transduction in response to DNA damage | 49/3246 | 172/18723 | 1.87e-04 | 1.65e-03 | 49 |
GO:000183615 | Prostate | Tumor | release of cytochrome c from mitochondria | 22/3246 | 59/18723 | 2.05e-04 | 1.79e-03 | 22 |
GO:000610912 | Prostate | Tumor | regulation of carbohydrate metabolic process | 50/3246 | 178/18723 | 2.36e-04 | 2.00e-03 | 50 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAIP1 | SNV | Missense_Mutation | | c.742N>T | p.Val248Phe | p.V248F | Q8WWC4 | protein_coding | tolerated(0.08) | benign(0.233) | TCGA-A8-A08S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
MAIP1 | SNV | Missense_Mutation | | c.340N>A | p.Gly114Arg | p.G114R | Q8WWC4 | protein_coding | deleterious(0.03) | possibly_damaging(0.905) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAIP1 | SNV | Missense_Mutation | novel | c.608N>C | p.Phe203Ser | p.F203S | Q8WWC4 | protein_coding | deleterious(0) | benign(0.091) | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAIP1 | SNV | Missense_Mutation | novel | c.781N>A | p.Leu261Ile | p.L261I | Q8WWC4 | protein_coding | tolerated(0.07) | possibly_damaging(0.521) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAIP1 | SNV | Missense_Mutation | | c.363N>T | p.Trp121Cys | p.W121C | Q8WWC4 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-BH-A0HY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | taxotere | CR |
MAIP1 | SNV | Missense_Mutation | | c.520G>C | p.Glu174Gln | p.E174Q | Q8WWC4 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
MAIP1 | insertion | Frame_Shift_Ins | novel | c.607_608insCTCA | p.Phe203SerfsTer13 | p.F203Sfs*13 | Q8WWC4 | protein_coding | | | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
MAIP1 | insertion | Frame_Shift_Ins | novel | c.646_647insTGGC | p.Lys216MetfsTer8 | p.K216Mfs*8 | Q8WWC4 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAIP1 | insertion | Frame_Shift_Ins | novel | c.647_648insGCCTAGATTTC | p.Gly217ProfsTer12 | p.G217Pfs*12 | Q8WWC4 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAIP1 | SNV | Missense_Mutation | novel | c.37N>T | p.His13Tyr | p.H13Y | Q8WWC4 | protein_coding | deleterious_low_confidence(0.02) | benign(0.006) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |