Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/KDM1A_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/KDM1A_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/KDM1A_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/KDM1A_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/KDM1A_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/KDM1A_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/KDM1A_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007233128 | Skin | AK | signal transduction by p53 class mediator | 41/1910 | 163/18723 | 3.41e-08 | 1.80e-06 | 41 |
GO:005109926 | Skin | AK | positive regulation of binding | 42/1910 | 173/18723 | 6.92e-08 | 3.38e-06 | 42 |
GO:00165709 | Skin | AK | histone modification | 84/1910 | 463/18723 | 1.10e-07 | 4.95e-06 | 84 |
GO:007138326 | Skin | AK | cellular response to steroid hormone stimulus | 46/1910 | 204/18723 | 1.79e-07 | 7.37e-06 | 46 |
GO:003052226 | Skin | AK | intracellular receptor signaling pathway | 55/1910 | 265/18723 | 2.26e-07 | 9.03e-06 | 55 |
GO:001072015 | Skin | AK | positive regulation of cell development | 59/1910 | 298/18723 | 4.52e-07 | 1.67e-05 | 59 |
GO:001097517 | Skin | AK | regulation of neuron projection development | 79/1910 | 445/18723 | 6.49e-07 | 2.23e-05 | 79 |
GO:007233227 | Skin | AK | intrinsic apoptotic signaling pathway by p53 class mediator | 23/1910 | 76/18723 | 1.12e-06 | 3.54e-05 | 23 |
GO:000863024 | Skin | AK | intrinsic apoptotic signaling pathway in response to DNA damage | 27/1910 | 99/18723 | 1.34e-06 | 4.15e-05 | 27 |
GO:007147810 | Skin | AK | cellular response to radiation | 41/1910 | 186/18723 | 1.53e-06 | 4.61e-05 | 41 |
GO:00507698 | Skin | AK | positive regulation of neurogenesis | 46/1910 | 225/18723 | 3.30e-06 | 8.56e-05 | 46 |
GO:000931420 | Skin | AK | response to radiation | 78/1910 | 456/18723 | 3.32e-06 | 8.59e-05 | 78 |
GO:005159120 | Skin | AK | response to cAMP | 25/1910 | 93/18723 | 4.33e-06 | 1.05e-04 | 25 |
GO:190179628 | Skin | AK | regulation of signal transduction by p53 class mediator | 25/1910 | 93/18723 | 4.33e-06 | 1.05e-04 | 25 |
GO:005076713 | Skin | AK | regulation of neurogenesis | 65/1910 | 364/18723 | 5.10e-06 | 1.19e-04 | 65 |
GO:19022299 | Skin | AK | regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 14/1910 | 36/18723 | 5.46e-06 | 1.26e-04 | 14 |
GO:00182058 | Skin | AK | peptidyl-lysine modification | 66/1910 | 376/18723 | 7.80e-06 | 1.72e-04 | 66 |
GO:00309006 | Skin | AK | forebrain development | 66/1910 | 379/18723 | 1.02e-05 | 2.17e-04 | 66 |
GO:00064799 | Skin | AK | protein methylation | 38/1910 | 181/18723 | 1.21e-05 | 2.46e-04 | 38 |
GO:00082139 | Skin | AK | protein alkylation | 38/1910 | 181/18723 | 1.21e-05 | 2.46e-04 | 38 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDM1A | SNV | Missense_Mutation | | c.1189G>C | p.Glu397Gln | p.E397Q | O60341 | protein_coding | tolerated(0.07) | possibly_damaging(0.552) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KDM1A | SNV | Missense_Mutation | | c.812G>A | p.Arg271Gln | p.R271Q | O60341 | protein_coding | deleterious(0.04) | probably_damaging(0.941) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KDM1A | SNV | Missense_Mutation | | c.2426N>G | p.Ser809Trp | p.S809W | O60341 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
KDM1A | SNV | Missense_Mutation | | c.1189N>A | p.Glu397Lys | p.E397K | O60341 | protein_coding | deleterious(0.01) | benign(0.413) | TCGA-W8-A86G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
KDM1A | insertion | Nonsense_Mutation | novel | c.677_678insATAGAGATGGAGAAGAATATTATTCCAAGCATACATTAATGT | p.Thr226_Gln227insTer | p.T226_Q227ins* | O60341 | protein_coding | | | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
KDM1A | insertion | Nonsense_Mutation | novel | c.1919_1920insGATGACAGTTGAGGATTCTGAAGTTGAC | p.Tyr640Ter | p.Y640* | O60341 | protein_coding | | | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
KDM1A | insertion | Frame_Shift_Ins | novel | c.1816_1817insGAGCGTGGTGGCTCATGCCTGTAATACCAGCACTT | p.Leu606ArgfsTer13 | p.L606Rfs*13 | O60341 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KDM1A | SNV | Missense_Mutation | | c.817C>A | p.His273Asn | p.H273N | O60341 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-EA-A1QS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KDM1A | SNV | Missense_Mutation | novel | c.358T>C | p.Tyr120His | p.Y120H | O60341 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.991) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KDM1A | SNV | Missense_Mutation | novel | c.1844G>T | p.Arg615Leu | p.R615L | O60341 | protein_coding | deleterious(0.02) | possibly_damaging(0.69) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 178103603 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 310264760 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | | TRANYLCYPROMINE HYDROCHLORIDE | TRANYLCYPROMINE HYDROCHLORIDE | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | | 2-[N-(PHTHALIMIDO)]ETHYL CARBAMIMIDOTHIOATE HCL | CHEMBL2182009 | 22876979 |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 249565921 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | activator | 252166601 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 178103602 | | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | inhibitor | 178101964 | TRANYLCYPROMINE | |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | | PARNATE | PARNATE | 21382717 |
23028 | KDM1A | DRUGGABLE GENOME, ENZYME, CELL SURFACE, TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR BINDING | | NAMOLINE | NAMOLINE | 24007511 |