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Gene: HSD17B1 |
Gene summary for HSD17B1 |
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Gene information | Species | Human | Gene symbol | HSD17B1 | Gene ID | 3292 |
Gene name | hydroxysteroid 17-beta dehydrogenase 1 | |
Gene Alias | 17-beta-HSD | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P14061 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3292 | HSD17B1 | LZE4T | Human | Esophagus | ESCC | 2.61e-07 | 1.87e-01 | 0.0811 |
3292 | HSD17B1 | P2T-E | Human | Esophagus | ESCC | 2.51e-05 | 1.49e-01 | 0.1177 |
3292 | HSD17B1 | P4T-E | Human | Esophagus | ESCC | 7.59e-11 | 3.06e-01 | 0.1323 |
3292 | HSD17B1 | P5T-E | Human | Esophagus | ESCC | 5.00e-29 | 5.68e-01 | 0.1327 |
3292 | HSD17B1 | P8T-E | Human | Esophagus | ESCC | 6.64e-11 | 1.01e-01 | 0.0889 |
3292 | HSD17B1 | P9T-E | Human | Esophagus | ESCC | 5.28e-04 | 1.92e-01 | 0.1131 |
3292 | HSD17B1 | P12T-E | Human | Esophagus | ESCC | 1.69e-02 | 2.64e-02 | 0.1122 |
3292 | HSD17B1 | P15T-E | Human | Esophagus | ESCC | 2.10e-02 | 6.50e-02 | 0.1149 |
3292 | HSD17B1 | P16T-E | Human | Esophagus | ESCC | 3.87e-03 | 3.75e-02 | 0.1153 |
3292 | HSD17B1 | P21T-E | Human | Esophagus | ESCC | 9.51e-11 | 2.40e-01 | 0.1617 |
3292 | HSD17B1 | P22T-E | Human | Esophagus | ESCC | 2.73e-49 | 8.56e-01 | 0.1236 |
3292 | HSD17B1 | P23T-E | Human | Esophagus | ESCC | 4.40e-05 | 2.12e-01 | 0.108 |
3292 | HSD17B1 | P24T-E | Human | Esophagus | ESCC | 1.81e-08 | 2.32e-01 | 0.1287 |
3292 | HSD17B1 | P26T-E | Human | Esophagus | ESCC | 3.90e-15 | 3.21e-01 | 0.1276 |
3292 | HSD17B1 | P27T-E | Human | Esophagus | ESCC | 3.07e-08 | 1.47e-01 | 0.1055 |
3292 | HSD17B1 | P28T-E | Human | Esophagus | ESCC | 4.39e-23 | 4.17e-01 | 0.1149 |
3292 | HSD17B1 | P30T-E | Human | Esophagus | ESCC | 6.24e-04 | 2.13e-01 | 0.137 |
3292 | HSD17B1 | P31T-E | Human | Esophagus | ESCC | 3.13e-07 | 1.08e-01 | 0.1251 |
3292 | HSD17B1 | P32T-E | Human | Esophagus | ESCC | 2.65e-24 | 3.65e-01 | 0.1666 |
3292 | HSD17B1 | P37T-E | Human | Esophagus | ESCC | 8.23e-08 | 2.31e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158926 | Skin | cSCC | cell-substrate adhesion | 130/4864 | 363/18723 | 1.87e-05 | 2.23e-04 | 130 |
GO:0006163112 | Skin | cSCC | purine nucleotide metabolic process | 140/4864 | 396/18723 | 1.93e-05 | 2.27e-04 | 140 |
GO:0009260111 | Skin | cSCC | ribonucleotide biosynthetic process | 73/4864 | 182/18723 | 2.01e-05 | 2.36e-04 | 73 |
GO:0009150112 | Skin | cSCC | purine ribonucleotide metabolic process | 131/4864 | 368/18723 | 2.42e-05 | 2.76e-04 | 131 |
GO:007252218 | Skin | cSCC | purine-containing compound biosynthetic process | 78/4864 | 200/18723 | 3.44e-05 | 3.74e-04 | 78 |
GO:190129310 | Skin | cSCC | nucleoside phosphate biosynthetic process | 95/4864 | 256/18723 | 5.21e-05 | 5.31e-04 | 95 |
GO:000916510 | Skin | cSCC | nucleotide biosynthetic process | 94/4864 | 254/18723 | 6.40e-05 | 6.25e-04 | 94 |
GO:0009152111 | Skin | cSCC | purine ribonucleotide biosynthetic process | 67/4864 | 169/18723 | 6.60e-05 | 6.43e-04 | 67 |
GO:000616418 | Skin | cSCC | purine nucleotide biosynthetic process | 73/4864 | 191/18723 | 1.28e-04 | 1.17e-03 | 73 |
GO:00991164 | Skin | cSCC | tRNA 5'-end processing | 11/4864 | 16/18723 | 4.08e-04 | 3.18e-03 | 11 |
GO:00009664 | Skin | cSCC | RNA 5'-end processing | 14/4864 | 23/18723 | 4.32e-04 | 3.34e-03 | 14 |
GO:00344714 | Skin | cSCC | ncRNA 5'-end processing | 13/4864 | 21/18723 | 5.53e-04 | 4.05e-03 | 13 |
GO:004341411 | Skin | cSCC | macromolecule methylation | 107/4864 | 316/18723 | 1.03e-03 | 6.94e-03 | 107 |
GO:00080334 | Skin | cSCC | tRNA processing | 49/4864 | 127/18723 | 1.20e-03 | 7.81e-03 | 49 |
GO:00322593 | Skin | cSCC | methylation | 120/4864 | 364/18723 | 1.61e-03 | 9.93e-03 | 120 |
GO:00063993 | Skin | cSCC | tRNA metabolic process | 64/4864 | 179/18723 | 2.34e-03 | 1.36e-02 | 64 |
GO:00512624 | Skin | cSCC | protein tetramerization | 35/4864 | 87/18723 | 2.52e-03 | 1.43e-02 | 35 |
GO:004578529 | Skin | cSCC | positive regulation of cell adhesion | 139/4864 | 437/18723 | 3.39e-03 | 1.84e-02 | 139 |
GO:001081128 | Skin | cSCC | positive regulation of cell-substrate adhesion | 46/4864 | 123/18723 | 3.41e-03 | 1.85e-02 | 46 |
GO:0043628 | Skin | cSCC | ncRNA 3'-end processing | 22/4864 | 50/18723 | 4.31e-03 | 2.27e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSD17B1 | SNV | Missense_Mutation | novel | c.367N>A | p.Leu123Met | p.L123M | protein_coding | deleterious(0.04) | possibly_damaging(0.697) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HSD17B1 | SNV | Missense_Mutation | c.400N>A | p.Gly134Ser | p.G134S | protein_coding | tolerated(0.13) | benign(0.206) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
HSD17B1 | SNV | Missense_Mutation | c.144N>T | p.Glu48Asp | p.E48D | protein_coding | tolerated(0.07) | possibly_damaging(0.717) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HSD17B1 | SNV | Missense_Mutation | c.609G>T | p.Glu203Asp | p.E203D | protein_coding | tolerated(0.62) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
HSD17B1 | SNV | Missense_Mutation | rs773613890 | c.530N>G | p.Phe177Cys | p.F177C | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AX-A2H2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD17B1 | SNV | Missense_Mutation | c.320N>T | p.Ala107Val | p.A107V | protein_coding | deleterious(0.02) | possibly_damaging(0.571) | TCGA-BG-A0M4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
HSD17B1 | SNV | Missense_Mutation | novel | c.337N>A | p.Asp113Asn | p.D113N | protein_coding | deleterious(0.04) | benign(0.359) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HSD17B1 | SNV | Missense_Mutation | novel | c.283G>T | p.Gly95Cys | p.G95C | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD17B1 | SNV | Missense_Mutation | c.404N>G | p.Ser135Trp | p.S135W | protein_coding | tolerated(0.05) | benign(0.35) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
HSD17B1 | SNV | Missense_Mutation | c.868C>T | p.Pro290Ser | p.P290S | protein_coding | tolerated(0.15) | benign(0.023) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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