Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/COA1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/COA1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/COA1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/COA1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/COA1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/COA1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732112 | Skin | SCCIS | gland development | 45/919 | 436/18723 | 2.12e-06 | 1.09e-04 | 45 |
GO:0071496112 | Skin | SCCIS | cellular response to external stimulus | 34/919 | 320/18723 | 2.01e-05 | 5.97e-04 | 34 |
GO:0001890111 | Skin | SCCIS | placenta development | 20/919 | 144/18723 | 2.53e-05 | 7.02e-04 | 20 |
GO:0031668112 | Skin | SCCIS | cellular response to extracellular stimulus | 26/919 | 246/18723 | 2.00e-04 | 3.79e-03 | 26 |
GO:003090014 | Skin | SCCIS | forebrain development | 34/919 | 379/18723 | 5.35e-04 | 8.26e-03 | 34 |
GO:0050878111 | Skin | SCCIS | regulation of body fluid levels | 34/919 | 379/18723 | 5.35e-04 | 8.26e-03 | 34 |
GO:003235517 | Skin | SCCIS | response to estradiol | 17/919 | 141/18723 | 5.55e-04 | 8.47e-03 | 17 |
GO:0031667112 | Skin | SCCIS | response to nutrient levels | 40/919 | 474/18723 | 6.21e-04 | 9.18e-03 | 40 |
GO:0030522111 | Skin | SCCIS | intracellular receptor signaling pathway | 26/919 | 265/18723 | 6.33e-04 | 9.33e-03 | 26 |
GO:006071114 | Skin | SCCIS | labyrinthine layer development | 8/919 | 44/18723 | 1.20e-03 | 1.42e-02 | 8 |
GO:0001701110 | Skin | SCCIS | in utero embryonic development | 32/919 | 367/18723 | 1.23e-03 | 1.45e-02 | 32 |
GO:0048545112 | Skin | SCCIS | response to steroid hormone | 30/919 | 339/18723 | 1.37e-03 | 1.57e-02 | 30 |
GO:0031669111 | Skin | SCCIS | cellular response to nutrient levels | 21/919 | 215/18723 | 2.13e-03 | 2.17e-02 | 21 |
GO:0001892110 | Skin | SCCIS | embryonic placenta development | 11/919 | 82/18723 | 2.16e-03 | 2.18e-02 | 11 |
GO:003252611 | Skin | SCCIS | response to retinoic acid | 13/919 | 107/18723 | 2.23e-03 | 2.24e-02 | 13 |
GO:001657016 | Skin | SCCIS | histone modification | 37/919 | 463/18723 | 2.53e-03 | 2.44e-02 | 37 |
GO:002153711 | Skin | SCCIS | telencephalon development | 23/919 | 248/18723 | 2.63e-03 | 2.48e-02 | 23 |
GO:003087916 | Skin | SCCIS | mammary gland development | 15/919 | 137/18723 | 3.00e-03 | 2.75e-02 | 15 |
GO:006071316 | Skin | SCCIS | labyrinthine layer morphogenesis | 5/919 | 22/18723 | 3.69e-03 | 3.22e-02 | 5 |
GO:003310824 | Skin | cSCC | mitochondrial respiratory chain complex assembly | 64/4864 | 93/18723 | 5.48e-18 | 6.58e-16 | 64 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COA1 | SNV | Missense_Mutation | novel | c.355G>A | p.Glu119Lys | p.E119K | Q9GZY4 | protein_coding | deleterious(0) | possibly_damaging(0.751) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COA1 | SNV | Missense_Mutation | | c.229G>A | p.Asp77Asn | p.D77N | Q9GZY4 | protein_coding | deleterious(0.03) | probably_damaging(0.91) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
COA1 | insertion | In_Frame_Ins | novel | c.340_341insAAGGAGTAGAGACGACCCAGAAGACCCAGCTTGCTTCTAGTCCAT | p.Arg114delinsLysGlyValGluThrThrGlnLysThrGlnLeuAlaSerSerProTrp | p.R114delinsKGVETTQKTQLASSPW | Q9GZY4 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
COA1 | SNV | Missense_Mutation | novel | c.247G>A | p.Asp83Asn | p.D83N | Q9GZY4 | protein_coding | deleterious(0.04) | possibly_damaging(0.833) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
COA1 | SNV | Missense_Mutation | | c.146T>C | p.Leu49Ser | p.L49S | Q9GZY4 | protein_coding | tolerated(0.11) | benign(0.079) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
COA1 | SNV | Missense_Mutation | rs140065703 | c.82N>A | p.Gly28Arg | p.G28R | Q9GZY4 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
COA1 | insertion | Frame_Shift_Ins | novel | c.365_366insT | p.Leu122PhefsTer20 | p.L122Ffs*20 | Q9GZY4 | protein_coding | | | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
COA1 | SNV | Missense_Mutation | | c.229N>T | p.Asp77Tyr | p.D77Y | Q9GZY4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
COA1 | SNV | Missense_Mutation | rs751652291 | c.32N>A | p.Arg11Gln | p.R11Q | Q9GZY4 | protein_coding | tolerated(0.67) | benign(0) | TCGA-D1-A16X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COA1 | SNV | Missense_Mutation | | c.229G>A | p.Asp77Asn | p.D77N | Q9GZY4 | protein_coding | deleterious(0.03) | probably_damaging(0.91) | TCGA-D1-A2G5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |