Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: CIT

Gene summary for CIT

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CIT

Gene ID

11113

Gene namecitron rho-interacting serine/threonine kinase
Gene AliasCITK
Cytomap12q24.23
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

O14578


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
11113CITTD9HumanLungIAC1.02e-025.71e-010.088
11113CITRNA-P6T1-P6T1-1HumanLungMIAC6.67e-049.05e-01-0.0238
Page: 1 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0051169112ThyroidPTCnuclear transport181/5968301/187232.93e-247.69e-22181
GO:0016055110ThyroidPTCWnt signaling pathway217/5968444/187233.71e-142.30e-12217
GO:0198738110ThyroidPTCcell-cell signaling by wnt217/5968446/187236.68e-143.73e-12217
GO:0030111110ThyroidPTCregulation of Wnt signaling pathway163/5968328/187231.05e-114.29e-10163
GO:007155919ThyroidPTCresponse to transforming growth factor beta131/5968256/187239.20e-113.17e-09131
GO:0001701111ThyroidPTCin utero embryonic development175/5968367/187231.40e-104.73e-09175
GO:0070482113ThyroidPTCresponse to oxygen levels167/5968347/187231.51e-105.03e-09167
GO:0070997113ThyroidPTCneuron death171/5968361/187234.32e-101.38e-08171
GO:007156019ThyroidPTCcellular response to transforming growth factor beta stimulus126/5968250/187237.34e-102.19e-08126
GO:000717919ThyroidPTCtransforming growth factor beta receptor signaling pathway104/5968198/187231.20e-093.47e-08104
GO:0036293113ThyroidPTCresponse to decreased oxygen levels153/5968322/187232.71e-097.52e-08153
GO:0043434113ThyroidPTCresponse to peptide hormone188/5968414/187234.13e-091.09e-07188
GO:1901214113ThyroidPTCregulation of neuron death151/5968319/187234.74e-091.24e-07151
GO:0001666113ThyroidPTCresponse to hypoxia145/5968307/187231.14e-082.74e-07145
GO:0048732113ThyroidPTCgland development193/5968436/187232.88e-086.42e-07193
GO:0001889112ThyroidPTCliver development79/5968147/187233.08e-086.82e-0779
GO:0061008112ThyroidPTChepaticobiliary system development80/5968150/187233.94e-088.55e-0780
GO:003052228ThyroidPTCintracellular receptor signaling pathway126/5968265/187236.31e-081.31e-06126
GO:0051402112ThyroidPTCneuron apoptotic process118/5968246/187238.99e-081.81e-06118
GO:004578718ThyroidPTCpositive regulation of cell cycle144/5968313/187239.93e-081.99e-06144
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CITSNVMissense_Mutationrs779515686c.4130N>Tp.Pro1377Leup.P1377LO14578protein_codingdeleterious(0)benign(0.248)TCGA-A2-A0EW-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapyadriamycinPD
CITSNVMissense_Mutationc.5132C>Tp.Ser1711Phep.S1711FO14578protein_codingdeleterious(0)probably_damaging(0.972)TCGA-A2-A0SV-01Breastbreast invasive carcinomaFemale<65III/IVOther, specify in notesBisphosphonate therapyzometaPD
CITSNVMissense_Mutationnovelc.2482N>Ap.Glu828Lysp.E828KO14578protein_codingdeleterious(0.04)possibly_damaging(0.628)TCGA-A2-A25C-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereSD
CITSNVMissense_Mutationc.3097G>Tp.Val1033Leup.V1033LO14578protein_codingtolerated(0.08)probably_damaging(0.978)TCGA-A8-A076-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
CITSNVMissense_Mutationrs747447396c.2839C>Tp.Arg947Cysp.R947CO14578protein_codingdeleterious(0.02)possibly_damaging(0.446)TCGA-A8-A09X-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownSD
CITSNVMissense_Mutationrs747447396c.2839N>Tp.Arg947Cysp.R947CO14578protein_codingdeleterious(0.02)possibly_damaging(0.446)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
CITSNVMissense_Mutationc.242N>Tp.Ser81Phep.S81FO14578protein_codingdeleterious(0.02)benign(0.17)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
CITSNVMissense_Mutationnovelc.637N>Tp.His213Tyrp.H213YO14578protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AC-A5XS-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyfemaraSD
CITSNVMissense_Mutationrs368981957c.5590N>Ap.Asp1864Asnp.D1864NO14578protein_codingdeleterious(0)probably_damaging(0.964)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CITSNVMissense_Mutationnovelc.1771N>Ap.Glu591Lysp.E591KO14578protein_codingtolerated(0.31)benign(0.019)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1