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Gene: CHMP2A |
Gene summary for CHMP2A |
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Gene information | Species | Human | Gene symbol | CHMP2A | Gene ID | 27243 |
Gene name | charged multivesicular body protein 2A | |
Gene Alias | BC-2 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | A0A024R4S0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27243 | CHMP2A | GSM4909286 | Human | Breast | IDC | 5.62e-07 | -3.08e-01 | 0.1081 |
27243 | CHMP2A | GSM4909287 | Human | Breast | IDC | 3.30e-03 | -3.23e-01 | 0.2057 |
27243 | CHMP2A | GSM4909294 | Human | Breast | IDC | 3.04e-66 | 9.18e-01 | 0.2022 |
27243 | CHMP2A | GSM4909296 | Human | Breast | IDC | 1.35e-06 | -3.47e-02 | 0.1524 |
27243 | CHMP2A | GSM4909297 | Human | Breast | IDC | 1.66e-15 | -1.42e-01 | 0.1517 |
27243 | CHMP2A | GSM4909301 | Human | Breast | IDC | 2.51e-05 | 3.11e-01 | 0.1577 |
27243 | CHMP2A | GSM4909302 | Human | Breast | IDC | 4.26e-08 | 2.82e-01 | 0.1545 |
27243 | CHMP2A | GSM4909307 | Human | Breast | IDC | 2.41e-10 | 4.08e-01 | 0.1569 |
27243 | CHMP2A | GSM4909308 | Human | Breast | IDC | 6.32e-18 | 5.22e-01 | 0.158 |
27243 | CHMP2A | GSM4909311 | Human | Breast | IDC | 1.01e-32 | -2.68e-01 | 0.1534 |
27243 | CHMP2A | GSM4909312 | Human | Breast | IDC | 5.17e-10 | -1.41e-01 | 0.1552 |
27243 | CHMP2A | GSM4909313 | Human | Breast | IDC | 1.08e-04 | 2.92e-02 | 0.0391 |
27243 | CHMP2A | GSM4909317 | Human | Breast | IDC | 1.57e-04 | 3.32e-01 | 0.1355 |
27243 | CHMP2A | GSM4909318 | Human | Breast | IDC | 2.16e-10 | 5.22e-01 | 0.2031 |
27243 | CHMP2A | GSM4909319 | Human | Breast | IDC | 1.04e-48 | -1.18e-01 | 0.1563 |
27243 | CHMP2A | GSM4909320 | Human | Breast | IDC | 4.07e-08 | 1.06e-01 | 0.1575 |
27243 | CHMP2A | GSM4909321 | Human | Breast | IDC | 2.64e-18 | 1.15e-01 | 0.1559 |
27243 | CHMP2A | brca1 | Human | Breast | Precancer | 5.44e-13 | 4.28e-01 | -0.0338 |
27243 | CHMP2A | brca2 | Human | Breast | Precancer | 2.52e-11 | 4.24e-01 | -0.024 |
27243 | CHMP2A | brca3 | Human | Breast | Precancer | 4.00e-12 | 3.51e-01 | -0.0263 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00009106 | Lung | IAC | cytokinesis | 31/2061 | 173/18723 | 4.28e-03 | 3.41e-02 | 31 |
GO:19028503 | Lung | IAC | microtubule cytoskeleton organization involved in mitosis | 27/2061 | 147/18723 | 5.23e-03 | 3.97e-02 | 27 |
GO:001603213 | Lung | AIS | viral process | 85/1849 | 415/18723 | 4.74e-11 | 1.95e-08 | 85 |
GO:001905813 | Lung | AIS | viral life cycle | 68/1849 | 317/18723 | 5.39e-10 | 1.16e-07 | 68 |
GO:005212613 | Lung | AIS | movement in host environment | 43/1849 | 175/18723 | 1.29e-08 | 1.88e-06 | 43 |
GO:005170113 | Lung | AIS | biological process involved in interaction with host | 47/1849 | 203/18723 | 2.09e-08 | 2.90e-06 | 47 |
GO:004440313 | Lung | AIS | biological process involved in symbiotic interaction | 58/1849 | 290/18723 | 1.33e-07 | 1.44e-05 | 58 |
GO:004477211 | Lung | AIS | mitotic cell cycle phase transition | 69/1849 | 424/18723 | 2.23e-05 | 7.42e-04 | 69 |
GO:004852412 | Lung | AIS | positive regulation of viral process | 18/1849 | 65/18723 | 3.92e-05 | 1.19e-03 | 18 |
GO:005125813 | Lung | AIS | protein polymerization | 51/1849 | 297/18723 | 6.29e-05 | 1.70e-03 | 51 |
GO:005079213 | Lung | AIS | regulation of viral process | 32/1849 | 164/18723 | 1.33e-04 | 2.97e-03 | 32 |
GO:190390213 | Lung | AIS | positive regulation of viral life cycle | 10/1849 | 29/18723 | 2.96e-04 | 5.51e-03 | 10 |
GO:190211511 | Lung | AIS | regulation of organelle assembly | 34/1849 | 186/18723 | 3.06e-04 | 5.62e-03 | 34 |
GO:000703412 | Lung | AIS | vacuolar transport | 30/1849 | 157/18723 | 3.09e-04 | 5.63e-03 | 30 |
GO:007050712 | Lung | AIS | regulation of microtubule cytoskeleton organization | 28/1849 | 148/18723 | 5.69e-04 | 8.89e-03 | 28 |
GO:005165612 | Lung | AIS | establishment of organelle localization | 59/1849 | 390/18723 | 6.08e-04 | 9.24e-03 | 59 |
GO:001623612 | Lung | AIS | macroautophagy | 46/1849 | 291/18723 | 9.21e-04 | 1.23e-02 | 46 |
GO:001619712 | Lung | AIS | endosomal transport | 38/1849 | 230/18723 | 1.08e-03 | 1.41e-02 | 38 |
GO:004390312 | Lung | AIS | regulation of biological process involved in symbiotic interaction | 16/1849 | 72/18723 | 1.50e-03 | 1.81e-02 | 16 |
GO:190390013 | Lung | AIS | regulation of viral life cycle | 26/1849 | 148/18723 | 2.64e-03 | 2.68e-02 | 26 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414416 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0414417 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414434 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414429 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144113 | Esophagus | HGIN | Endocytosis | 76/1383 | 251/8465 | 1.74e-08 | 3.34e-07 | 2.65e-07 | 76 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP2A | SNV | Missense_Mutation | novel | c.423N>C | p.Glu141Asp | p.E141D | O43633 | protein_coding | tolerated(0.06) | possibly_damaging(0.717) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | novel | c.445G>A | p.Asp149Asn | p.D149N | O43633 | protein_coding | tolerated(0.09) | possibly_damaging(0.817) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
CHMP2A | SNV | Missense_Mutation | novel | c.289N>G | p.Asn97Asp | p.N97D | O43633 | protein_coding | tolerated(0.41) | benign(0.021) | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | rs376979258 | c.220C>T | p.Arg74Cys | p.R74C | O43633 | protein_coding | deleterious(0.01) | possibly_damaging(0.806) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CHMP2A | SNV | Missense_Mutation | rs144804005 | c.539N>T | p.Ser180Leu | p.S180L | O43633 | protein_coding | tolerated(0.32) | benign(0.022) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CHMP2A | SNV | Missense_Mutation | novel | c.152N>T | p.Ala51Val | p.A51V | O43633 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | c.605C>T | p.Ala202Val | p.A202V | O43633 | protein_coding | tolerated(0.07) | benign(0.017) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHMP2A | SNV | Missense_Mutation | novel | c.308N>C | p.Met103Thr | p.M103T | O43633 | protein_coding | deleterious(0) | possibly_damaging(0.838) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | novel | c.497A>C | p.Gln166Pro | p.Q166P | O43633 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHMP2A | SNV | Missense_Mutation | novel | c.178N>T | p.Arg60Cys | p.R60C | O43633 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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