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Gene: C4A |
Gene summary for C4A |
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Gene information | Species | Human | Gene symbol | C4A | Gene ID | 720 |
Gene name | complement C4A (Rodgers blood group) | |
Gene Alias | C4 | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0002250 | UniProtAcc | P0C0L4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
720 | C4A | S014 | Human | Liver | HCC | 3.64e-16 | 5.83e-01 | 0.2254 |
720 | C4A | S015 | Human | Liver | HCC | 1.31e-05 | 2.94e-01 | 0.2375 |
720 | C4A | S016 | Human | Liver | HCC | 3.39e-08 | 2.64e-01 | 0.2243 |
720 | C4A | S027 | Human | Liver | HCC | 9.18e-07 | 6.14e-01 | 0.2446 |
720 | C4A | S028 | Human | Liver | HCC | 4.40e-18 | 4.44e-01 | 0.2503 |
720 | C4A | S029 | Human | Liver | HCC | 3.57e-22 | 7.57e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00460346 | Stomach | GC | ATP metabolic process | 73/1159 | 277/18723 | 5.03e-27 | 1.37e-23 | 73 |
GO:00060916 | Stomach | GC | generation of precursor metabolites and energy | 88/1159 | 490/18723 | 6.82e-20 | 9.27e-17 | 88 |
GO:00091506 | Stomach | GC | purine ribonucleotide metabolic process | 56/1159 | 368/18723 | 3.67e-10 | 5.39e-08 | 56 |
GO:00061636 | Stomach | GC | purine nucleotide metabolic process | 58/1159 | 396/18723 | 7.97e-10 | 1.11e-07 | 58 |
GO:00092595 | Stomach | GC | ribonucleotide metabolic process | 56/1159 | 385/18723 | 2.03e-09 | 2.69e-07 | 56 |
GO:00725216 | Stomach | GC | purine-containing compound metabolic process | 58/1159 | 416/18723 | 5.19e-09 | 5.76e-07 | 58 |
GO:00196935 | Stomach | GC | ribose phosphate metabolic process | 56/1159 | 396/18723 | 5.72e-09 | 6.22e-07 | 56 |
GO:00091176 | Stomach | GC | nucleotide metabolic process | 64/1159 | 489/18723 | 1.05e-08 | 9.84e-07 | 64 |
GO:00067536 | Stomach | GC | nucleoside phosphate metabolic process | 64/1159 | 497/18723 | 1.97e-08 | 1.63e-06 | 64 |
GO:00091856 | Stomach | GC | ribonucleoside diphosphate metabolic process | 20/1159 | 106/18723 | 6.84e-06 | 2.57e-04 | 20 |
GO:00091326 | Stomach | GC | nucleoside diphosphate metabolic process | 22/1159 | 124/18723 | 6.89e-06 | 2.57e-04 | 22 |
GO:00091356 | Stomach | GC | purine nucleoside diphosphate metabolic process | 19/1159 | 103/18723 | 1.62e-05 | 5.14e-04 | 19 |
GO:00091796 | Stomach | GC | purine ribonucleoside diphosphate metabolic process | 19/1159 | 103/18723 | 1.62e-05 | 5.14e-04 | 19 |
GO:00020646 | Stomach | GC | epithelial cell development | 30/1159 | 220/18723 | 3.92e-05 | 9.90e-04 | 30 |
GO:00469396 | Stomach | GC | nucleotide phosphorylation | 18/1159 | 101/18723 | 4.33e-05 | 1.06e-03 | 18 |
GO:00620124 | Stomach | GC | regulation of small molecule metabolic process | 40/1159 | 334/18723 | 4.84e-05 | 1.15e-03 | 40 |
GO:00061656 | Stomach | GC | nucleoside diphosphate phosphorylation | 17/1159 | 99/18723 | 1.13e-04 | 2.16e-03 | 17 |
GO:00434675 | Stomach | GC | regulation of generation of precursor metabolites and energy | 20/1159 | 130/18723 | 1.43e-04 | 2.64e-03 | 20 |
GO:00313316 | Stomach | GC | positive regulation of cellular catabolic process | 46/1159 | 427/18723 | 1.79e-04 | 3.12e-03 | 46 |
GO:00060906 | Stomach | GC | pyruvate metabolic process | 17/1159 | 106/18723 | 2.66e-04 | 4.39e-03 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517142 | Liver | HCC | Coronavirus disease - COVID-19 | 167/4020 | 232/8465 | 1.50e-14 | 4.19e-13 | 2.33e-13 | 167 |
hsa049362 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa046104 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa051332 | Liver | HCC | Pertussis | 48/4020 | 76/8465 | 4.17e-03 | 1.27e-02 | 7.06e-03 | 48 |
hsa0517152 | Liver | HCC | Coronavirus disease - COVID-19 | 167/4020 | 232/8465 | 1.50e-14 | 4.19e-13 | 2.33e-13 | 167 |
hsa049363 | Liver | HCC | Alcoholic liver disease | 89/4020 | 142/8465 | 1.73e-04 | 8.53e-04 | 4.75e-04 | 89 |
hsa046105 | Liver | HCC | Complement and coagulation cascades | 57/4020 | 86/8465 | 3.19e-04 | 1.45e-03 | 8.04e-04 | 57 |
hsa051333 | Liver | HCC | Pertussis | 48/4020 | 76/8465 | 4.17e-03 | 1.27e-02 | 7.06e-03 | 48 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
C4A | C3AR1 | C4A_C3AR1 | COMPLEMENT | Endometrium | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C4A | SNV | Missense_Mutation | novel | c.2544G>C | p.Gln848His | p.Q848H | P0C0L4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A18F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
C4A | SNV | Missense_Mutation | novel | c.4115N>T | p.Gly1372Val | p.G1372V | P0C0L4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A12L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C4A | SNV | Missense_Mutation | rs767169624 | c.3442G>A | p.Ala1148Thr | p.A1148T | P0C0L4 | protein_coding | deleterious(0) | possibly_damaging(0.666) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
C4A | SNV | Missense_Mutation | novel | c.3526N>C | p.Asn1176His | p.N1176H | P0C0L4 | protein_coding | tolerated(0.21) | benign(0.059) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C4A | SNV | Missense_Mutation | rs749075087 | c.3179N>A | p.Arg1060Gln | p.R1060Q | P0C0L4 | protein_coding | tolerated(0.52) | probably_damaging(0.983) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
C4A | SNV | Missense_Mutation | c.3604N>G | p.Leu1202Val | p.L1202V | P0C0L4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
C4A | SNV | Missense_Mutation | c.2695N>C | p.Phe899Leu | p.F899L | P0C0L4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AG-4005-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | CR | |
C4A | SNV | Missense_Mutation | rs370461806 | c.2758G>A | p.Glu920Lys | p.E920K | P0C0L4 | protein_coding | tolerated(0.11) | benign(0.093) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C4A | SNV | Missense_Mutation | novel | c.4137N>T | p.Lys1379Asn | p.K1379N | P0C0L4 | protein_coding | deleterious(0.04) | probably_damaging(0.99) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C4A | SNV | Missense_Mutation | novel | c.2509N>A | p.Leu837Ile | p.L837I | P0C0L4 | protein_coding | deleterious(0.01) | possibly_damaging(0.675) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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