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Gene: TTN |
Gene summary for TTN |
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Gene information | Species | Human | Gene symbol | TTN | Gene ID | 7273 |
Gene name | titin | |
Gene Alias | CMD1G | |
Cytomap | 2q31.2 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q8WZ42 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7273 | TTN | HCC1_Meng | Human | Liver | HCC | 1.93e-02 | -1.44e-01 | 0.0246 |
7273 | TTN | HCC5 | Human | Liver | HCC | 6.34e-15 | 2.72e+00 | 0.4932 |
7273 | TTN | S028 | Human | Liver | HCC | 7.08e-10 | 6.89e-01 | 0.2503 |
7273 | TTN | S029 | Human | Liver | HCC | 1.04e-02 | 3.61e-01 | 0.2581 |
7273 | TTN | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 2.80e-10 | 5.59e-01 | -0.2116 |
7273 | TTN | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.21e-06 | 7.26e-01 | -0.1941 |
7273 | TTN | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.26e-07 | 6.77e-01 | -0.2107 |
7273 | TTN | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.27e-10 | 6.99e-01 | -0.2119 |
7273 | TTN | HTA12-18-3 | Human | Pancreas | PDAC | 1.07e-02 | 5.78e-01 | 0.0716 |
7273 | TTN | HTA12-25-1 | Human | Pancreas | PDAC | 2.02e-02 | 4.06e-01 | 0.313 |
7273 | TTN | HTA12-26-1 | Human | Pancreas | PDAC | 1.84e-07 | 4.56e-01 | 0.3728 |
7273 | TTN | HTA12-29-1 | Human | Pancreas | PDAC | 3.65e-29 | 6.66e-01 | 0.3722 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00329708 | Lung | IAC | regulation of actin filament-based process | 77/2061 | 397/18723 | 4.85e-07 | 3.10e-05 | 77 |
GO:00105066 | Lung | IAC | regulation of autophagy | 65/2061 | 317/18723 | 4.97e-07 | 3.14e-05 | 65 |
GO:00605605 | Lung | IAC | developmental growth involved in morphogenesis | 52/2061 | 234/18723 | 5.39e-07 | 3.32e-05 | 52 |
GO:00160496 | Lung | IAC | cell growth | 89/2061 | 482/18723 | 6.10e-07 | 3.67e-05 | 89 |
GO:20012368 | Lung | IAC | regulation of extrinsic apoptotic signaling pathway | 38/2061 | 151/18723 | 7.33e-07 | 4.14e-05 | 38 |
GO:00329568 | Lung | IAC | regulation of actin cytoskeleton organization | 70/2061 | 358/18723 | 1.17e-06 | 6.20e-05 | 70 |
GO:19029038 | Lung | IAC | regulation of supramolecular fiber organization | 73/2061 | 383/18723 | 1.87e-06 | 8.87e-05 | 73 |
GO:00971918 | Lung | IAC | extrinsic apoptotic signaling pathway | 47/2061 | 219/18723 | 5.11e-06 | 2.03e-04 | 47 |
GO:00485885 | Lung | IAC | developmental cell growth | 49/2061 | 234/18723 | 6.67e-06 | 2.43e-04 | 49 |
GO:00068985 | Lung | IAC | receptor-mediated endocytosis | 50/2061 | 244/18723 | 1.01e-05 | 3.23e-04 | 50 |
GO:00163116 | Lung | IAC | dephosphorylation | 75/2061 | 417/18723 | 1.21e-05 | 3.64e-04 | 75 |
GO:01100538 | Lung | IAC | regulation of actin filament organization | 54/2061 | 278/18723 | 2.27e-05 | 6.28e-04 | 54 |
GO:00486755 | Lung | IAC | axon extension | 29/2061 | 120/18723 | 3.29e-05 | 8.29e-04 | 29 |
GO:00512588 | Lung | IAC | protein polymerization | 56/2061 | 297/18723 | 3.90e-05 | 9.51e-04 | 56 |
GO:19901384 | Lung | IAC | neuron projection extension | 37/2061 | 172/18723 | 4.69e-05 | 1.08e-03 | 37 |
GO:20012378 | Lung | IAC | negative regulation of extrinsic apoptotic signaling pathway | 24/2061 | 97/18723 | 1.03e-04 | 2.02e-03 | 24 |
GO:00615646 | Lung | IAC | axon development | 78/2061 | 467/18723 | 1.12e-04 | 2.15e-03 | 78 |
GO:00486385 | Lung | IAC | regulation of developmental growth | 59/2061 | 330/18723 | 1.17e-04 | 2.22e-03 | 59 |
GO:00074096 | Lung | IAC | axonogenesis | 71/2061 | 418/18723 | 1.33e-04 | 2.48e-03 | 71 |
GO:01060276 | Lung | IAC | neuron projection organization | 23/2061 | 93/18723 | 1.43e-04 | 2.64e-03 | 23 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa054142 | Lung | AIS | Dilated cardiomyopathy | 22/961 | 96/8465 | 9.02e-04 | 7.11e-03 | 4.55e-03 | 22 |
hsa054102 | Lung | AIS | Hypertrophic cardiomyopathy | 20/961 | 90/8465 | 2.25e-03 | 1.37e-02 | 8.80e-03 | 20 |
hsa054143 | Lung | AIS | Dilated cardiomyopathy | 22/961 | 96/8465 | 9.02e-04 | 7.11e-03 | 4.55e-03 | 22 |
hsa054103 | Lung | AIS | Hypertrophic cardiomyopathy | 20/961 | 90/8465 | 2.25e-03 | 1.37e-02 | 8.80e-03 | 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTN | SNV | Missense_Mutation | rs557526069 | c.35041G>A | p.Glu11681Lys | p.E11681K | protein_coding | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |||
TTN | SNV | Missense_Mutation | novel | c.31372N>C | p.Val10458Leu | p.V10458L | protein_coding | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
TTN | SNV | Missense_Mutation | c.69142N>A | p.Glu23048Lys | p.E23048K | protein_coding | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||||
TTN | SNV | Missense_Mutation | novel | c.105331G>C | p.Glu35111Gln | p.E35111Q | protein_coding | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |||
TTN | SNV | Missense_Mutation | novel | c.91713G>A | p.Met30571Ile | p.M30571I | protein_coding | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |||
TTN | SNV | Missense_Mutation | c.31520A>T | p.Glu10507Val | p.E10507V | protein_coding | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |||||
TTN | SNV | Missense_Mutation | novel | c.43021N>A | p.Glu14341Lys | p.E14341K | protein_coding | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |||
TTN | SNV | Missense_Mutation | c.58960N>T | p.Val19654Phe | p.V19654F | protein_coding | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | ||||
TTN | SNV | Missense_Mutation | novel | c.38183N>T | p.Lys12728Ile | p.K12728I | protein_coding | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |||
TTN | SNV | Missense_Mutation | novel | c.10739C>G | p.Ala3580Gly | p.A3580G | protein_coding | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7273 | TTN | DRUGGABLE GENOME, TYROSINE KINASE, SERINE THREONINE KINASE, KINASE, ENZYME | PROTEASE INHIBITORS | 9648223 |
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