Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

	Gene summary
	Malignant transformation analysis
	Malignant transformation related pathway analysis
	Cell-cell communication analysis
	Single-cell gene regulatory network inference analysis
	Somatic mutation of malignant transformation related genes
	Related drugs of malignant transformation related genes

Gene: SH3RF1

Gene summary for SH3RF1

Gene summary.

Gene information	Species	Human
	Gene symbol	SH3RF1
	Gene ID	57630
	Gene name	SH3 domain containing ring finger 1
	Gene Alias	POSH
	Cytomap	4q32.3-q33
	Gene Type	protein-coding
	GO ID	GO:0000165
	UniProtAcc	Q7Z6J0

Top

Malignant transformation analysis

Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells

Malignant transformation involving gene list.

Entrez ID	Symbol	Replicates	Species	Organ	Tissue	Adj P-value	Log2FC	Malignancy
57630	SH3RF1	CCI_1	Human	Cervix	CC	8.77e-10	7.13e-01	0.528
57630	SH3RF1	CCI_2	Human	Cervix	CC	2.14e-03	5.27e-01	0.5249
57630	SH3RF1	CCI_3	Human	Cervix	CC	2.92e-07	6.07e-01	0.516
57630	SH3RF1	T1	Human	Cervix	CC	2.07e-02	1.85e-01	0.0918
57630	SH3RF1	HTA11_3410_2000001011	Human	Colorectum	AD	1.31e-31	-9.14e-01	0.0155
57630	SH3RF1	HTA11_2487_2000001011	Human	Colorectum	SER	4.92e-03	-4.63e-01	-0.1808
57630	SH3RF1	HTA11_2951_2000001011	Human	Colorectum	AD	6.88e-06	-9.61e-01	0.0216
57630	SH3RF1	HTA11_347_2000001011	Human	Colorectum	AD	2.95e-04	3.70e-01	-0.1954
57630	SH3RF1	HTA11_3361_2000001011	Human	Colorectum	AD	7.56e-11	-6.46e-01	-0.1207
57630	SH3RF1	HTA11_696_2000001011	Human	Colorectum	AD	1.50e-10	-4.57e-01	-0.1464
57630	SH3RF1	HTA11_5216_2000001011	Human	Colorectum	SER	2.37e-06	-7.54e-01	-0.1462
57630	SH3RF1	HTA11_9341_2000001011	Human	Colorectum	SER	8.99e-05	-7.00e-01	-0.00410000000000005
57630	SH3RF1	HTA11_866_3004761011	Human	Colorectum	AD	1.52e-32	-9.19e-01	0.096
57630	SH3RF1	HTA11_9408_2000001011	Human	Colorectum	AD	7.93e-03	-8.64e-01	0.0451
57630	SH3RF1	HTA11_8622_2000001021	Human	Colorectum	SER	3.78e-09	-1.00e+00	0.0528
57630	SH3RF1	HTA11_7663_2000001011	Human	Colorectum	SER	2.07e-06	-5.26e-01	0.0131
57630	SH3RF1	HTA11_10711_2000001011	Human	Colorectum	AD	2.57e-12	-6.95e-01	0.0338
57630	SH3RF1	HTA11_7696_3000711011	Human	Colorectum	AD	2.65e-38	-8.33e-01	0.0674
57630	SH3RF1	HTA11_7469_2000001011	Human	Colorectum	AD	4.73e-02	-5.64e-01	-0.0124
57630	SH3RF1	HTA11_11156_2000001011	Human	Colorectum	AD	1.52e-03	-9.57e-01	0.0397

Page: 1 2 3 4 5 6 7 8 9 10

Transcriptomic changes along malignancy continuum.

Tissue	Expression Dynamics	Abbreviation
Cervix		CC: Cervix cancer
		HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
		N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)		FAP: Familial adenomatous polyposis
		CRC: Colorectal cancer
Colorectum (HTA11)		AD: Adenomas
		SER: Sessile serrated lesions
		MSI-H: Microsatellite-high colorectal cancer
		MSS: Microsatellite stable colorectal cancer
Endometrium		AEH: Atypical endometrial hyperplasia
		EEC: Endometrioid Cancer
Esophagus		ESCC: Esophageal squamous cell carcinoma
		HGIN: High-grade intraepithelial neoplasias
		LGIN: Low-grade intraepithelial neoplasias
Liver		HCC: Hepatocellular carcinoma
		NAFLD: Non-alcoholic fatty liver disease
Lung		AAH: Atypical adenomatous hyperplasia
		AIS: Adenocarcinoma in situ
		IAC: Invasive lung adenocarcinoma
		MIA: Minimally invasive adenocarcinoma
Prostate		BPH: Benign Prostatic Hyperplasia
Skin		AK: Actinic keratosis
		cSCC: Cutaneous squamous cell carcinoma
		SCCIS:squamous cell carcinoma in situ
Thyroid		ATC: Anaplastic thyroid cancer
		HT: Hashimoto's thyroiditis
		PTC: Papillary thyroid cancer

∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer

Figure of enriched GO biological processes.

Tissue	Disease Stage	Enriched GO biological Processes
Colorectum	AD
Colorectum	SER
Colorectum	MSS
Colorectum	MSI-H
Colorectum	FAP

∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).

Page: 1 2 3 4 5 6 7 8 9

Enriched GO biological processes.

GO ID	Tissue	Disease Stage	Description	Gene Ratio	Bg Ratio	pvalue	p.adjust	Count
GO:2001236113	Thyroid	PTC	regulation of extrinsic apoptotic signaling pathway	82/5968	151/18723	9.01e-09	2.18e-07	82
GO:0043281113	Thyroid	PTC	regulation of cysteine-type endopeptidase activity involved in apoptotic process	99/5968	209/18723	1.93e-06	2.64e-05	99
GO:0031098111	Thyroid	PTC	stress-activated protein kinase signaling cascade	113/5968	247/18723	3.16e-06	4.10e-05	113
GO:2000116113	Thyroid	PTC	regulation of cysteine-type endopeptidase activity	108/5968	235/18723	3.99e-06	4.99e-05	108
GO:0052547113	Thyroid	PTC	regulation of peptidase activity	191/5968	461/18723	7.82e-06	9.02e-05	191
GO:0051403111	Thyroid	PTC	stress-activated MAPK cascade	108/5968	239/18723	1.02e-05	1.13e-04	108
GO:2001237113	Thyroid	PTC	negative regulation of extrinsic apoptotic signaling pathway	51/5968	97/18723	1.83e-05	1.88e-04	51
GO:00518659	Thyroid	PTC	protein autoubiquitination	40/5968	73/18723	4.17e-05	3.80e-04	40
GO:0052548113	Thyroid	PTC	regulation of endopeptidase activity	174/5968	432/18723	1.20e-04	9.55e-04	174
GO:0043154112	Thyroid	PTC	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	40/5968	78/18723	2.83e-04	2.01e-03	40
GO:2000117112	Thyroid	PTC	negative regulation of cysteine-type endopeptidase activity	43/5968	86/18723	3.49e-04	2.40e-03	43
GO:000725419	Thyroid	PTC	JNK cascade	73/5968	167/18723	8.41e-04	5.17e-03	73
GO:0070302110	Thyroid	PTC	regulation of stress-activated protein kinase signaling cascade	83/5968	195/18723	1.04e-03	6.21e-03	83
GO:0032872110	Thyroid	PTC	regulation of stress-activated MAPK cascade	81/5968	192/18723	1.62e-03	8.95e-03	81
GO:0051346112	Thyroid	PTC	negative regulation of hydrolase activity	146/5968	379/18723	3.33e-03	1.62e-02	146
GO:0045861113	Thyroid	PTC	negative regulation of proteolysis	136/5968	351/18723	3.54e-03	1.71e-02	136
GO:200123335	Thyroid	ATC	regulation of apoptotic signaling pathway	206/6293	356/18723	2.81e-21	5.92e-19	206
GO:2001234210	Thyroid	ATC	negative regulation of apoptotic signaling pathway	129/6293	224/18723	1.26e-13	6.46e-12	129
GO:0097191210	Thyroid	ATC	extrinsic apoptotic signaling pathway	125/6293	219/18723	7.19e-13	3.16e-11	125
GO:2001236210	Thyroid	ATC	regulation of extrinsic apoptotic signaling pathway	89/6293	151/18723	1.43e-10	4.40e-09	89

Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31

Enriched KEGG pathways.

Pathway ID

Tissue

Disease Stage

Description

Gene Ratio

Bg Ratio

pvalue

p.adjust

qvalue

Count

Page: 1

Top

Cell-cell communication analysis

Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states

Ligand

Receptor

LRpair

Pathway

Tissue

Disease Stage

Page: 1

Top

Single-cell gene regulatory network inference analysis

Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states

Cell Type

Tissue

Disease Stage

Target Gene

RSS

Regulon Activity

∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.

Page: 1

Top

Somatic mutation of malignant transformation related genes

Annotation of somatic variants for genes involved in malignant transformation

Hugo Symbol

Variant Class

Variant Classification

dbSNP RS

HGVSc

HGVSp

HGVSp Short

SWISSPROT

BIOTYPE

SIFT

PolyPhen

Tumor Sample Barcode

Tissue

Histology

Sex

Age

Stage

Therapy Types

Drugs

Outcome

SH3RF1

SNV

Missense_Mutation

novel

c.2350N>T

p.Ala784Ser

p.A784S

Q7Z6J0

protein_coding

tolerated(1)

benign(0)

TCGA-A8-A07W-01

Breast

breast invasive carcinoma

Female

>=65

III/IV

Hormone Therapy

exemestane

SH3RF1

SNV

Missense_Mutation

novel

c.2125N>C

p.Asp709His

p.D709H

Q7Z6J0

protein_coding

deleterious(0.01)

probably_damaging(0.997)

TCGA-AC-A5EH-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Unknown

SH3RF1

SNV

Missense_Mutation

novel

c.1762N>G

p.Asn588Asp

p.N588D

Q7Z6J0

protein_coding

tolerated(0.06)

benign(0.112)

TCGA-AO-A128-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

SH3RF1

SNV

Missense_Mutation

c.1033G>A

p.Glu345Lys

p.E345K

Q7Z6J0

protein_coding

deleterious(0.01)

probably_damaging(0.94)

TCGA-AR-A250-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

SH3RF1

SNV

Missense_Mutation

novel

c.1129N>A

p.Gly377Ser

p.G377S

Q7Z6J0

protein_coding

tolerated(0.11)

possibly_damaging(0.661)

TCGA-D8-A73U-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Hormone Therapy

tamoxiphen

SH3RF1

insertion

Frame_Shift_Ins

novel

c.411_412insGCCCACCTGGTGTCCTTTCCAAC

p.Cys138AlafsTer80

p.C138Afs*80

Q7Z6J0

protein_coding

TCGA-AO-A128-01

Breast

breast invasive carcinoma

Female

<65

I/II

Chemotherapy

doxorubicin

SH3RF1

insertion

Nonsense_Mutation

novel

c.2194_2195insGTTCCAGGAAAAAACTAAAAAATGAACAATAG

p.Pro732ArgfsTer11

p.P732Rfs*11

Q7Z6J0

protein_coding

TCGA-BH-A0B1-01

Breast

breast invasive carcinoma

Female

>=65

I/II

Chemotherapy

adriamycin

SH3RF1

SNV

Missense_Mutation

novel

c.1726N>T

p.His576Tyr

p.H576Y

Q7Z6J0

protein_coding

deleterious(0.01)

benign(0.172)

TCGA-EA-A3HS-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

SH3RF1

SNV

Missense_Mutation

novel

c.578C>T

p.Pro193Leu

p.P193L

Q7Z6J0

protein_coding

deleterious(0)

benign(0.158)

TCGA-EA-A3HU-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

SH3RF1

SNV

Missense_Mutation

rs755524119

c.1569N>C

p.Gln523His

p.Q523H

Q7Z6J0

protein_coding

tolerated(0.15)

possibly_damaging(0.556)

TCGA-EK-A3GJ-01

Cervix

cervical & endocervical cancer

Female

<65

I/II

Unknown

Page: 1 2 3 4 5 6 7 8 9

Top

Related drugs of malignant transformation related genes

Identification of chemicals and drugs interact with genes involved in malignant transfromation

(DGIdb 4.0)

Entrez ID

Symbol

Category

Interaction Types

Drug Claim Name

Drug Name

PMIDs

Page: 1