Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/PUM2_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PUM2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PUM2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/PUM2_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PUM2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PUM2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/PUM2_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/PUM2_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/PUM2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/PUM2_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030522112 | Thyroid | ATC | intracellular receptor signaling pathway | 134/6293 | 265/18723 | 7.58e-09 | 1.63e-07 | 134 |
GO:0009615111 | Thyroid | ATC | response to virus | 173/6293 | 367/18723 | 4.23e-08 | 7.71e-07 | 173 |
GO:003406323 | Thyroid | ATC | stress granule assembly | 20/6293 | 26/18723 | 7.65e-06 | 7.83e-05 | 20 |
GO:006014823 | Thyroid | ATC | positive regulation of posttranscriptional gene silencing | 22/6293 | 31/18723 | 2.35e-05 | 2.06e-04 | 22 |
GO:000283123 | Thyroid | ATC | regulation of response to biotic stimulus | 144/6293 | 327/18723 | 4.94e-05 | 3.91e-04 | 144 |
GO:200063724 | Thyroid | ATC | positive regulation of gene silencing by miRNA | 21/6293 | 30/18723 | 5.03e-05 | 3.96e-04 | 21 |
GO:003952815 | Thyroid | ATC | cytoplasmic pattern recognition receptor signaling pathway in response to virus | 23/6293 | 34/18723 | 5.15e-05 | 3.99e-04 | 23 |
GO:000275315 | Thyroid | ATC | cytoplasmic pattern recognition receptor signaling pathway | 35/6293 | 60/18723 | 7.31e-05 | 5.56e-04 | 35 |
GO:006014717 | Thyroid | ATC | regulation of posttranscriptional gene silencing | 31/6293 | 52/18723 | 1.06e-04 | 7.61e-04 | 31 |
GO:006096616 | Thyroid | ATC | regulation of gene silencing by RNA | 31/6293 | 53/18723 | 1.74e-04 | 1.19e-03 | 31 |
GO:006096418 | Thyroid | ATC | regulation of gene silencing by miRNA | 29/6293 | 49/18723 | 2.11e-04 | 1.39e-03 | 29 |
GO:003210324 | Thyroid | ATC | positive regulation of response to external stimulus | 178/6293 | 427/18723 | 2.61e-04 | 1.67e-03 | 178 |
GO:000222114 | Thyroid | ATC | pattern recognition receptor signaling pathway | 80/6293 | 172/18723 | 2.89e-04 | 1.84e-03 | 80 |
GO:009858615 | Thyroid | ATC | cellular response to virus | 44/6293 | 84/18723 | 2.94e-04 | 1.87e-03 | 44 |
GO:003952914 | Thyroid | ATC | RIG-I signaling pathway | 18/6293 | 27/18723 | 4.53e-04 | 2.68e-03 | 18 |
GO:005160712 | Thyroid | ATC | defense response to virus | 115/6293 | 265/18723 | 5.31e-04 | 3.09e-03 | 115 |
GO:014054612 | Thyroid | ATC | defense response to symbiont | 115/6293 | 265/18723 | 5.31e-04 | 3.09e-03 | 115 |
GO:003519617 | Thyroid | ATC | production of miRNAs involved in gene silencing by miRNA | 29/6293 | 52/18723 | 8.30e-04 | 4.57e-03 | 29 |
GO:003105016 | Thyroid | ATC | dsRNA processing | 29/6293 | 54/18723 | 1.84e-03 | 9.03e-03 | 29 |
GO:007091816 | Thyroid | ATC | production of small RNA involved in gene silencing by RNA | 29/6293 | 54/18723 | 1.84e-03 | 9.03e-03 | 29 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PUM2 | SNV | Missense_Mutation | | c.2534A>C | p.Asp845Ala | p.D845A | Q8TB72 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PUM2 | SNV | Missense_Mutation | | c.1364N>G | p.Thr455Ser | p.T455S | Q8TB72 | protein_coding | tolerated(0.26) | benign(0.041) | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PUM2 | SNV | Missense_Mutation | rs372196772 | c.536N>A | p.Arg179His | p.R179H | Q8TB72 | protein_coding | tolerated(0.15) | possibly_damaging(0.796) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
PUM2 | SNV | Missense_Mutation | | c.308N>T | p.Pro103Leu | p.P103L | Q8TB72 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
PUM2 | SNV | Missense_Mutation | rs761103124 | c.502G>A | p.Asp168Asn | p.D168N | Q8TB72 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
PUM2 | SNV | Missense_Mutation | | c.562N>A | p.Glu188Lys | p.E188K | Q8TB72 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.465) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PUM2 | SNV | Missense_Mutation | | c.2147A>G | p.Asn716Ser | p.N716S | Q8TB72 | protein_coding | tolerated(0.13) | benign(0.194) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PUM2 | SNV | Missense_Mutation | | c.364N>A | p.Glu122Lys | p.E122K | Q8TB72 | protein_coding | tolerated_low_confidence(0.22) | possibly_damaging(0.465) | TCGA-C8-A12Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PUM2 | insertion | Nonsense_Mutation | novel | c.1525_1526insTATTGTTTCTTATGTTTTTTTTATGA | p.Gln509LeufsTer9 | p.Q509Lfs*9 | Q8TB72 | protein_coding | | | TCGA-A2-A0EM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
PUM2 | deletion | Frame_Shift_Del | novel | c.2019delT | p.Arg674GlufsTer54 | p.R674Efs*54 | Q8TB72 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |