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Gene: PTGS2 |
Gene summary for PTGS2 |
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Gene information | Species | Human | Gene symbol | PTGS2 | Gene ID | 5743 |
Gene name | prostaglandin-endoperoxide synthase 2 | |
Gene Alias | COX-2 | |
Cytomap | 1q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P35354 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5743 | PTGS2 | CA_HPV_1 | Human | Cervix | CC | 4.42e-06 | -3.38e-01 | 0.0264 |
5743 | PTGS2 | CA_HPV_3 | Human | Cervix | CC | 3.42e-05 | -3.79e-01 | 0.0414 |
5743 | PTGS2 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 3.79e-03 | -4.77e-01 | 0.0116 |
5743 | PTGS2 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 3.67e-21 | -5.75e-01 | 0.0208 |
5743 | PTGS2 | CCI_2 | Human | Cervix | CC | 3.48e-04 | -6.44e-01 | 0.5249 |
5743 | PTGS2 | CCI_3 | Human | Cervix | CC | 1.36e-04 | -6.28e-01 | 0.516 |
5743 | PTGS2 | CCII_1 | Human | Cervix | CC | 5.10e-10 | -6.44e-01 | 0.3249 |
5743 | PTGS2 | Tumor | Human | Cervix | CC | 9.63e-19 | -6.01e-01 | 0.1241 |
5743 | PTGS2 | sample3 | Human | Cervix | CC | 2.31e-07 | -4.77e-01 | 0.1387 |
5743 | PTGS2 | L1 | Human | Cervix | CC | 3.88e-11 | -6.44e-01 | 0.0802 |
5743 | PTGS2 | T3 | Human | Cervix | CC | 2.50e-10 | -4.74e-01 | 0.1389 |
5743 | PTGS2 | LZE8T | Human | Esophagus | ESCC | 5.97e-05 | -2.52e-02 | 0.067 |
5743 | PTGS2 | LZE24T | Human | Esophagus | ESCC | 2.55e-02 | -2.90e-01 | 0.0596 |
5743 | PTGS2 | P9T-E | Human | Esophagus | ESCC | 2.80e-31 | 1.89e+00 | 0.1131 |
5743 | PTGS2 | P10T-E | Human | Esophagus | ESCC | 3.24e-02 | -2.03e-01 | 0.116 |
5743 | PTGS2 | P12T-E | Human | Esophagus | ESCC | 1.89e-02 | -2.71e-01 | 0.1122 |
5743 | PTGS2 | P16T-E | Human | Esophagus | ESCC | 3.36e-02 | -2.43e-01 | 0.1153 |
5743 | PTGS2 | P24T-E | Human | Esophagus | ESCC | 7.63e-03 | -2.69e-01 | 0.1287 |
5743 | PTGS2 | P32T-E | Human | Esophagus | ESCC | 1.67e-03 | -2.40e-01 | 0.1666 |
5743 | PTGS2 | P61T-E | Human | Esophagus | ESCC | 5.69e-09 | 9.51e-01 | 0.099 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:009719326 | Oral cavity | EOLP | intrinsic apoptotic signaling pathway | 84/2218 | 288/18723 | 1.29e-15 | 7.05e-13 | 84 |
GO:007259425 | Oral cavity | EOLP | establishment of protein localization to organelle | 108/2218 | 422/18723 | 2.91e-15 | 1.45e-12 | 108 |
GO:003238622 | Oral cavity | EOLP | regulation of intracellular transport | 91/2218 | 337/18723 | 1.51e-14 | 6.47e-12 | 91 |
GO:001810514 | Oral cavity | EOLP | peptidyl-serine phosphorylation | 84/2218 | 315/18723 | 3.32e-13 | 1.05e-10 | 84 |
GO:200124226 | Oral cavity | EOLP | regulation of intrinsic apoptotic signaling pathway | 54/2218 | 164/18723 | 8.03e-13 | 2.09e-10 | 54 |
GO:001820914 | Oral cavity | EOLP | peptidyl-serine modification | 87/2218 | 338/18723 | 1.07e-12 | 2.46e-10 | 87 |
GO:200011625 | Oral cavity | EOLP | regulation of cysteine-type endopeptidase activity | 67/2218 | 235/18723 | 3.12e-12 | 6.45e-10 | 67 |
GO:005254725 | Oral cavity | EOLP | regulation of peptidase activity | 105/2218 | 461/18723 | 1.86e-11 | 2.79e-09 | 105 |
GO:004328125 | Oral cavity | EOLP | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 60/2218 | 209/18723 | 3.09e-11 | 4.30e-09 | 60 |
GO:003315722 | Oral cavity | EOLP | regulation of intracellular protein transport | 63/2218 | 229/18723 | 7.28e-11 | 9.09e-09 | 63 |
GO:005254825 | Oral cavity | EOLP | regulation of endopeptidase activity | 98/2218 | 432/18723 | 1.12e-10 | 1.29e-08 | 98 |
GO:200123426 | Oral cavity | EOLP | negative regulation of apoptotic signaling pathway | 61/2218 | 224/18723 | 2.28e-10 | 2.20e-08 | 61 |
GO:004682222 | Oral cavity | EOLP | regulation of nucleocytoplasmic transport | 37/2218 | 106/18723 | 4.85e-10 | 4.04e-08 | 37 |
GO:003450422 | Oral cavity | EOLP | protein localization to nucleus | 72/2218 | 290/18723 | 5.47e-10 | 4.31e-08 | 72 |
GO:003460523 | Oral cavity | EOLP | cellular response to heat | 28/2218 | 69/18723 | 1.22e-09 | 8.34e-08 | 28 |
GO:005122225 | Oral cavity | EOLP | positive regulation of protein transport | 72/2218 | 303/18723 | 4.20e-09 | 2.41e-07 | 72 |
GO:000756825 | Oral cavity | EOLP | aging | 78/2218 | 339/18723 | 4.55e-09 | 2.55e-07 | 78 |
GO:003238822 | Oral cavity | EOLP | positive regulation of intracellular transport | 54/2218 | 202/18723 | 4.95e-09 | 2.74e-07 | 54 |
GO:0001667110 | Oral cavity | EOLP | ameboidal-type cell migration | 100/2218 | 475/18723 | 5.24e-09 | 2.85e-07 | 100 |
GO:001063119 | Oral cavity | EOLP | epithelial cell migration | 80/2218 | 357/18723 | 1.03e-08 | 4.97e-07 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0516720 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa0516318 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0465718 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0472318 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa052226 | Cervix | CC | Small cell lung cancer | 29/1267 | 92/8465 | 4.38e-05 | 3.09e-04 | 1.83e-04 | 29 |
hsa051657 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
hsa0514014 | Cervix | CC | Leishmaniasis | 21/1267 | 77/8465 | 3.65e-03 | 1.34e-02 | 7.91e-03 | 21 |
hsa046686 | Cervix | CC | TNF signaling pathway | 28/1267 | 114/8465 | 4.60e-03 | 1.62e-02 | 9.59e-03 | 28 |
hsa046254 | Cervix | CC | C-type lectin receptor signaling pathway | 25/1267 | 104/8465 | 9.52e-03 | 2.94e-02 | 1.74e-02 | 25 |
hsa049218 | Cervix | CC | Oxytocin signaling pathway | 34/1267 | 154/8465 | 1.12e-02 | 3.42e-02 | 2.02e-02 | 34 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa05167110 | Cervix | CC | Kaposi sarcoma-associated herpesvirus infection | 60/1267 | 194/8465 | 9.74e-09 | 1.58e-07 | 9.33e-08 | 60 |
hsa0516319 | Cervix | CC | Human cytomegalovirus infection | 65/1267 | 225/8465 | 4.59e-08 | 6.47e-07 | 3.83e-07 | 65 |
hsa0465719 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0472319 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa0522213 | Cervix | CC | Small cell lung cancer | 29/1267 | 92/8465 | 4.38e-05 | 3.09e-04 | 1.83e-04 | 29 |
hsa0516512 | Cervix | CC | Human papillomavirus infection | 74/1267 | 331/8465 | 1.70e-04 | 1.02e-03 | 6.03e-04 | 74 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTGS2 | SNV | Missense_Mutation | novel | c.1298N>A | p.Val433Glu | p.V433E | P35354 | protein_coding | deleterious(0.01) | benign(0.219) | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGS2 | SNV | Missense_Mutation | rs200204426 | c.898G>A | p.Asp300Asn | p.D300N | P35354 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTGS2 | SNV | Missense_Mutation | c.112G>A | p.Asp38Asn | p.D38N | P35354 | protein_coding | tolerated(0.1) | benign(0.014) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
PTGS2 | SNV | Missense_Mutation | c.691C>T | p.Arg231Cys | p.R231C | P35354 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A1QZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTGS2 | SNV | Missense_Mutation | c.297N>A | p.Met99Ile | p.M99I | P35354 | protein_coding | deleterious(0) | possibly_damaging(0.672) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PTGS2 | SNV | Missense_Mutation | novel | c.1565G>A | p.Gly522Asp | p.G522D | P35354 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PTGS2 | SNV | Missense_Mutation | c.1358G>A | p.Arg453His | p.R453H | P35354 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PTGS2 | SNV | Missense_Mutation | rs200132172 | c.284G>A | p.Arg95Gln | p.R95Q | P35354 | protein_coding | tolerated(0.11) | benign(0.028) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PTGS2 | SNV | Missense_Mutation | c.1738N>G | p.Asn580Asp | p.N580D | P35354 | protein_coding | tolerated(0.11) | benign(0.205) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTGS2 | SNV | Missense_Mutation | novel | c.1492N>G | p.Pro498Ala | p.P498A | P35354 | protein_coding | tolerated(0.19) | benign(0.011) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | Tolmetin | TOLMETIN | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL599 | MELOXICAM | |
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | IBUPROFEN | IBUPROFEN | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | PHENYLBUTAZONE | PHENYLBUTAZONE | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | NEPAFENAC | NEPAFENAC | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL2105683 | NAPROXEN ETEMESIL | |
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | atenolol | ATENOLOL | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL876 | MECLOFENAMATE SODIUM | |
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | OXAPROZIN | OXAPROZIN | ||
5743 | PTGS2 | DRUGGABLE GENOME, ENZYME | KETOPROFEN | KETOPROFEN |
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