![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PRELID1 |
Gene summary for PRELID1 |
![]() |
Gene information | Species | Human | Gene symbol | PRELID1 | Gene ID | 27166 |
Gene name | PRELI domain containing 1 | |
Gene Alias | CGI-106 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q9Y255 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27166 | PRELID1 | GSM4909281 | Human | Breast | IDC | 9.70e-05 | -2.05e-01 | 0.21 |
27166 | PRELID1 | GSM4909285 | Human | Breast | IDC | 2.17e-04 | 2.54e-02 | 0.21 |
27166 | PRELID1 | GSM4909286 | Human | Breast | IDC | 1.04e-23 | -4.97e-01 | 0.1081 |
27166 | PRELID1 | GSM4909293 | Human | Breast | IDC | 3.82e-13 | -2.20e-01 | 0.1581 |
27166 | PRELID1 | GSM4909296 | Human | Breast | IDC | 2.31e-13 | -4.17e-01 | 0.1524 |
27166 | PRELID1 | GSM4909297 | Human | Breast | IDC | 5.74e-24 | -5.27e-01 | 0.1517 |
27166 | PRELID1 | GSM4909298 | Human | Breast | IDC | 5.27e-04 | 7.77e-02 | 0.1551 |
27166 | PRELID1 | GSM4909308 | Human | Breast | IDC | 6.15e-06 | 8.85e-02 | 0.158 |
27166 | PRELID1 | GSM4909311 | Human | Breast | IDC | 3.09e-42 | -5.16e-01 | 0.1534 |
27166 | PRELID1 | GSM4909312 | Human | Breast | IDC | 3.51e-09 | -2.26e-01 | 0.1552 |
27166 | PRELID1 | GSM4909317 | Human | Breast | IDC | 3.50e-02 | -9.36e-02 | 0.1355 |
27166 | PRELID1 | GSM4909319 | Human | Breast | IDC | 1.55e-52 | -3.95e-01 | 0.1563 |
27166 | PRELID1 | GSM4909321 | Human | Breast | IDC | 5.01e-10 | -7.32e-02 | 0.1559 |
27166 | PRELID1 | ctrl6 | Human | Breast | Precancer | 5.50e-03 | -3.97e-01 | -0.0061 |
27166 | PRELID1 | brca1 | Human | Breast | Precancer | 4.47e-30 | 5.94e-01 | -0.0338 |
27166 | PRELID1 | brca3 | Human | Breast | Precancer | 3.08e-02 | 2.33e-01 | -0.0263 |
27166 | PRELID1 | M1 | Human | Breast | IDC | 8.37e-03 | -2.33e-01 | 0.1577 |
27166 | PRELID1 | NCCBC14 | Human | Breast | DCIS | 8.62e-06 | -2.67e-01 | 0.2021 |
27166 | PRELID1 | NCCBC5 | Human | Breast | DCIS | 5.49e-12 | -1.44e-01 | 0.2046 |
27166 | PRELID1 | P1 | Human | Breast | IDC | 3.63e-29 | -7.52e-01 | 0.1527 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004346726 | Thyroid | ATC | regulation of generation of precursor metabolites and energy | 68/6293 | 130/18723 | 8.19e-06 | 8.27e-05 | 68 |
GO:001095233 | Thyroid | ATC | positive regulation of peptidase activity | 94/6293 | 197/18723 | 2.67e-05 | 2.28e-04 | 94 |
GO:0001836111 | Thyroid | ATC | release of cytochrome c from mitochondria | 34/6293 | 59/18723 | 1.29e-04 | 9.10e-04 | 34 |
GO:005254834 | Thyroid | ATC | regulation of endopeptidase activity | 181/6293 | 432/18723 | 1.70e-04 | 1.16e-03 | 181 |
GO:007188711 | Thyroid | ATC | leukocyte apoptotic process | 53/6293 | 106/18723 | 3.48e-04 | 2.16e-03 | 53 |
GO:004345722 | Thyroid | ATC | regulation of cellular respiration | 28/6293 | 49/18723 | 6.01e-04 | 3.43e-03 | 28 |
GO:009019915 | Thyroid | ATC | regulation of release of cytochrome c from mitochondria | 27/6293 | 48/18723 | 1.04e-03 | 5.50e-03 | 27 |
GO:001095033 | Thyroid | ATC | positive regulation of endopeptidase activity | 79/6293 | 179/18723 | 2.09e-03 | 9.86e-03 | 79 |
GO:001082319 | Thyroid | ATC | negative regulation of mitochondrion organization | 26/6293 | 49/18723 | 3.87e-03 | 1.68e-02 | 26 |
GO:1903706112 | Thyroid | ATC | regulation of hemopoiesis | 148/6293 | 367/18723 | 3.87e-03 | 1.68e-02 | 148 |
GO:20001062 | Thyroid | ATC | regulation of leukocyte apoptotic process | 39/6293 | 81/18723 | 4.65e-03 | 1.92e-02 | 39 |
GO:00702272 | Thyroid | ATC | lymphocyte apoptotic process | 35/6293 | 72/18723 | 5.89e-03 | 2.37e-02 | 35 |
GO:00702311 | Thyroid | ATC | T cell apoptotic process | 25/6293 | 50/18723 | 1.20e-02 | 4.27e-02 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRELID1 | SNV | Missense_Mutation | rs758980479 | c.514N>A | p.Glu172Lys | p.E172K | Q9Y255 | protein_coding | tolerated(0.25) | benign(0.013) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PRELID1 | SNV | Missense_Mutation | c.197C>T | p.Ala66Val | p.A66V | Q9Y255 | protein_coding | deleterious(0.01) | possibly_damaging(0.733) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRELID1 | SNV | Missense_Mutation | c.610N>A | p.Ala204Thr | p.A204T | Q9Y255 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRELID1 | SNV | Missense_Mutation | c.436N>G | p.Phe146Val | p.F146V | Q9Y255 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PRELID1 | SNV | Missense_Mutation | rs758358635 | c.383G>A | p.Arg128Gln | p.R128Q | Q9Y255 | protein_coding | tolerated(0.08) | probably_damaging(0.989) | TCGA-KR-A7K0-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRELID1 | SNV | Missense_Mutation | novel | c.413G>C | p.Gly138Ala | p.G138A | Q9Y255 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-ZS-A9CE-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PRELID1 | SNV | Missense_Mutation | c.125G>T | p.Arg42Leu | p.R42L | Q9Y255 | protein_coding | tolerated(0.07) | benign(0.396) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PRELID1 | SNV | Missense_Mutation | novel | c.481G>T | p.Gly161Cys | p.G161C | Q9Y255 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PRELID1 | SNV | Missense_Mutation | c.594G>C | p.Glu198Asp | p.E198D | Q9Y255 | protein_coding | deleterious(0.03) | probably_damaging(0.935) | TCGA-34-5929-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRELID1 | SNV | Missense_Mutation | novel | c.380G>T | p.Arg127Leu | p.R127L | Q9Y255 | protein_coding | tolerated(0.1) | benign(0.049) | TCGA-CQ-6228-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |