Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/OGT_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/OGT_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/OGT_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/OGT_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/OGT_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000675724 | Oral cavity | NEOLP | ATP generation from ADP | 20/2005 | 82/18723 | 3.21e-04 | 3.11e-03 | 20 |
GO:004693932 | Oral cavity | NEOLP | nucleotide phosphorylation | 23/2005 | 101/18723 | 3.50e-04 | 3.37e-03 | 23 |
GO:200005933 | Oral cavity | NEOLP | negative regulation of ubiquitin-dependent protein catabolic process | 14/2005 | 48/18723 | 3.56e-04 | 3.41e-03 | 14 |
GO:003496822 | Oral cavity | NEOLP | histone lysine methylation | 25/2005 | 115/18723 | 4.21e-04 | 3.89e-03 | 25 |
GO:004657815 | Oral cavity | NEOLP | regulation of Ras protein signal transduction | 36/2005 | 189/18723 | 4.30e-04 | 3.92e-03 | 36 |
GO:004603132 | Oral cavity | NEOLP | ADP metabolic process | 21/2005 | 90/18723 | 4.39e-04 | 3.97e-03 | 21 |
GO:005160432 | Oral cavity | NEOLP | protein maturation | 50/2005 | 294/18723 | 6.46e-04 | 5.47e-03 | 50 |
GO:000616532 | Oral cavity | NEOLP | nucleoside diphosphate phosphorylation | 22/2005 | 99/18723 | 6.64e-04 | 5.54e-03 | 22 |
GO:190357824 | Oral cavity | NEOLP | regulation of ATP metabolic process | 20/2005 | 87/18723 | 7.28e-04 | 5.97e-03 | 20 |
GO:003106021 | Oral cavity | NEOLP | regulation of histone methylation | 17/2005 | 69/18723 | 7.76e-04 | 6.23e-03 | 17 |
GO:000758423 | Oral cavity | NEOLP | response to nutrient | 33/2005 | 174/18723 | 7.89e-04 | 6.27e-03 | 33 |
GO:00310622 | Oral cavity | NEOLP | positive regulation of histone methylation | 12/2005 | 41/18723 | 8.94e-04 | 7.02e-03 | 12 |
GO:004217732 | Oral cavity | NEOLP | negative regulation of protein catabolic process | 25/2005 | 121/18723 | 9.29e-04 | 7.20e-03 | 25 |
GO:001648521 | Oral cavity | NEOLP | protein processing | 39/2005 | 225/18723 | 1.68e-03 | 1.17e-02 | 39 |
GO:005105614 | Oral cavity | NEOLP | regulation of small GTPase mediated signal transduction | 49/2005 | 302/18723 | 2.04e-03 | 1.36e-02 | 49 |
GO:000828622 | Oral cavity | NEOLP | insulin receptor signaling pathway | 23/2005 | 116/18723 | 2.56e-03 | 1.61e-02 | 23 |
GO:190305132 | Oral cavity | NEOLP | negative regulation of proteolysis involved in cellular protein catabolic process | 15/2005 | 64/18723 | 2.63e-03 | 1.65e-02 | 15 |
GO:004346733 | Oral cavity | NEOLP | regulation of generation of precursor metabolites and energy | 25/2005 | 130/18723 | 2.65e-03 | 1.66e-02 | 25 |
GO:001802213 | Oral cavity | NEOLP | peptidyl-lysine methylation | 25/2005 | 131/18723 | 2.95e-03 | 1.81e-02 | 25 |
GO:00439842 | Oral cavity | NEOLP | histone H4-K16 acetylation | 7/2005 | 20/18723 | 3.51e-03 | 2.06e-02 | 7 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OGT | SNV | Missense_Mutation | novel | c.1945N>C | p.Glu649Gln | p.E649Q | O15294 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
OGT | SNV | Missense_Mutation | novel | c.278C>T | p.Ser93Leu | p.S93L | O15294 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OGT | SNV | Missense_Mutation | rs267606503 | c.1042C>T | p.Arg348Cys | p.R348C | O15294 | protein_coding | deleterious(0.01) | benign(0.158) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OGT | SNV | Missense_Mutation | novel | c.1612C>A | p.Leu538Ile | p.L538I | O15294 | protein_coding | deleterious(0.03) | benign(0.08) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OGT | SNV | Missense_Mutation | rs778629433 | c.557N>T | p.Thr186Met | p.T186M | O15294 | protein_coding | tolerated(0.11) | probably_damaging(0.995) | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | | SD |
OGT | SNV | Missense_Mutation | rs200109331 | c.588N>G | p.Asn196Lys | p.N196K | O15294 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0RX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
OGT | SNV | Missense_Mutation | | c.1288N>A | p.Asp430Asn | p.D430N | O15294 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
OGT | SNV | Missense_Mutation | | c.1390N>A | p.Asp464Asn | p.D464N | O15294 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD |
OGT | SNV | Missense_Mutation | | c.2861N>T | p.Arg954Leu | p.R954L | O15294 | protein_coding | deleterious(0) | possibly_damaging(0.825) | TCGA-LL-A6FP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
OGT | SNV | Missense_Mutation | novel | c.687C>G | p.Ile229Met | p.I229M | O15294 | protein_coding | tolerated(0.06) | probably_damaging(1) | TCGA-XX-A89A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |