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Gene: LTF |
Gene summary for LTF |
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Gene information | Species | Human | Gene symbol | LTF | Gene ID | 4057 |
Gene name | lactotransferrin | |
Gene Alias | GIG12 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | P02788 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4057 | LTF | GSM4909281 | Human | Breast | IDC | 5.56e-33 | -1.03e+00 | 0.21 |
4057 | LTF | GSM4909282 | Human | Breast | IDC | 7.90e-28 | -1.02e+00 | -0.0288 |
4057 | LTF | GSM4909285 | Human | Breast | IDC | 2.90e-36 | -1.03e+00 | 0.21 |
4057 | LTF | GSM4909286 | Human | Breast | IDC | 1.04e-39 | -1.06e+00 | 0.1081 |
4057 | LTF | GSM4909290 | Human | Breast | IDC | 5.79e-18 | -9.40e-01 | 0.2096 |
4057 | LTF | GSM4909291 | Human | Breast | IDC | 2.52e-25 | -1.06e+00 | 0.1753 |
4057 | LTF | GSM4909292 | Human | Breast | IDC | 4.67e-03 | -1.02e+00 | 0.1236 |
4057 | LTF | GSM4909293 | Human | Breast | IDC | 1.54e-19 | -8.64e-01 | 0.1581 |
4057 | LTF | GSM4909294 | Human | Breast | IDC | 1.28e-10 | -7.48e-01 | 0.2022 |
4057 | LTF | GSM4909295 | Human | Breast | IDC | 1.79e-02 | -5.38e-01 | 0.0898 |
4057 | LTF | GSM4909296 | Human | Breast | IDC | 1.05e-16 | -8.38e-01 | 0.1524 |
4057 | LTF | GSM4909297 | Human | Breast | IDC | 1.05e-21 | -8.89e-01 | 0.1517 |
4057 | LTF | GSM4909298 | Human | Breast | IDC | 1.27e-22 | -9.17e-01 | 0.1551 |
4057 | LTF | GSM4909299 | Human | Breast | IDC | 8.72e-03 | -3.57e-01 | 0.035 |
4057 | LTF | GSM4909300 | Human | Breast | IDC | 1.24e-10 | 7.27e-01 | 0.0334 |
4057 | LTF | GSM4909301 | Human | Breast | IDC | 2.02e-34 | -1.04e+00 | 0.1577 |
4057 | LTF | GSM4909302 | Human | Breast | IDC | 1.53e-18 | -8.54e-01 | 0.1545 |
4057 | LTF | GSM4909303 | Human | Breast | IDC | 3.43e-06 | -8.90e-01 | 0.0438 |
4057 | LTF | GSM4909304 | Human | Breast | IDC | 3.95e-37 | -1.05e+00 | 0.1636 |
4057 | LTF | GSM4909306 | Human | Breast | IDC | 8.26e-09 | -6.78e-01 | 0.1564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005254719 | Prostate | Tumor | regulation of peptidase activity | 137/3246 | 461/18723 | 2.48e-11 | 1.71e-09 | 137 |
GO:005254819 | Prostate | Tumor | regulation of endopeptidase activity | 126/3246 | 432/18723 | 5.86e-10 | 3.01e-08 | 126 |
GO:200011619 | Prostate | Tumor | regulation of cysteine-type endopeptidase activity | 79/3246 | 235/18723 | 9.68e-10 | 4.66e-08 | 79 |
GO:000164915 | Prostate | Tumor | osteoblast differentiation | 77/3246 | 229/18723 | 1.55e-09 | 7.26e-08 | 77 |
GO:004586119 | Prostate | Tumor | negative regulation of proteolysis | 102/3246 | 351/18723 | 3.09e-08 | 9.94e-07 | 102 |
GO:001907919 | Prostate | Tumor | viral genome replication | 49/3246 | 131/18723 | 3.31e-08 | 1.06e-06 | 49 |
GO:005079219 | Prostate | Tumor | regulation of viral process | 57/3246 | 164/18723 | 5.45e-08 | 1.64e-06 | 57 |
GO:004563719 | Prostate | Tumor | regulation of myeloid cell differentiation | 67/3246 | 210/18723 | 1.71e-07 | 4.25e-06 | 67 |
GO:190370617 | Prostate | Tumor | regulation of hemopoiesis | 103/3246 | 367/18723 | 1.78e-07 | 4.38e-06 | 103 |
GO:003367417 | Prostate | Tumor | positive regulation of kinase activity | 123/3246 | 467/18723 | 5.36e-07 | 1.15e-05 | 123 |
GO:004586015 | Prostate | Tumor | positive regulation of protein kinase activity | 105/3246 | 386/18723 | 7.09e-07 | 1.43e-05 | 105 |
GO:000150314 | Prostate | Tumor | ossification | 109/3246 | 408/18723 | 1.13e-06 | 2.14e-05 | 109 |
GO:007190014 | Prostate | Tumor | regulation of protein serine/threonine kinase activity | 98/3246 | 359/18723 | 1.39e-06 | 2.51e-05 | 98 |
GO:200011717 | Prostate | Tumor | negative regulation of cysteine-type endopeptidase activity | 32/3246 | 86/18723 | 8.65e-06 | 1.27e-04 | 32 |
GO:005507615 | Prostate | Tumor | transition metal ion homeostasis | 45/3246 | 138/18723 | 9.11e-06 | 1.33e-04 | 45 |
GO:000257314 | Prostate | Tumor | myeloid leukocyte differentiation | 61/3246 | 208/18723 | 1.26e-05 | 1.76e-04 | 61 |
GO:190390019 | Prostate | Tumor | regulation of viral life cycle | 47/3246 | 148/18723 | 1.29e-05 | 1.78e-04 | 47 |
GO:000724916 | Prostate | Tumor | I-kappaB kinase/NF-kappaB signaling | 77/3246 | 281/18723 | 1.55e-05 | 2.09e-04 | 77 |
GO:004506916 | Prostate | Tumor | regulation of viral genome replication | 31/3246 | 85/18723 | 1.89e-05 | 2.47e-04 | 31 |
GO:005507213 | Prostate | Tumor | iron ion homeostasis | 31/3246 | 85/18723 | 1.89e-05 | 2.47e-04 | 31 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LTF | SNV | Missense_Mutation | novel | c.1299C>G | p.Asn433Lys | p.N433K | P02788 | protein_coding | tolerated(0.1) | probably_damaging(0.927) | TCGA-A2-A3Y0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
LTF | SNV | Missense_Mutation | c.2090N>T | p.Ser697Leu | p.S697L | P02788 | protein_coding | tolerated(0.21) | benign(0.083) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
LTF | SNV | Missense_Mutation | c.513N>G | p.Phe171Leu | p.F171L | P02788 | protein_coding | deleterious(0.01) | benign(0.24) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
LTF | insertion | Frame_Shift_Ins | novel | c.1876_1877insTGAGAGAGCT | p.Glu626ValfsTer16 | p.E626Vfs*16 | P02788 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LTF | SNV | Missense_Mutation | novel | c.676G>A | p.Ala226Thr | p.A226T | P02788 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LTF | SNV | Missense_Mutation | c.286G>T | p.Val96Leu | p.V96L | P02788 | protein_coding | deleterious(0.03) | possibly_damaging(0.455) | TCGA-EA-A5ZF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
LTF | SNV | Missense_Mutation | c.1963N>C | p.Ser655Pro | p.S655P | P02788 | protein_coding | deleterious(0.02) | possibly_damaging(0.836) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LTF | SNV | Missense_Mutation | rs776865450 | c.145N>T | p.Arg49Cys | p.R49C | P02788 | protein_coding | deleterious(0.04) | possibly_damaging(0.79) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LTF | SNV | Missense_Mutation | rs776865450 | c.145N>T | p.Arg49Cys | p.R49C | P02788 | protein_coding | deleterious(0.04) | possibly_damaging(0.79) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LTF | SNV | Missense_Mutation | rs765686239 | c.206N>T | p.Ala69Val | p.A69V | P02788 | protein_coding | tolerated(0.24) | benign(0.023) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | BACITRACIN | BACITRACIN | 12042436 | |
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | HLF 1-11 | |||
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | Talactoferrin | TALACTOFERRIN ALFA | ||
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | RESERPINE | RESERPINE | 3608900 | |
4057 | LTF | CELL SURFACE, TRANSCRIPTION FACTOR, DRUGGABLE GENOME, PROTEASE | Parecoxib | PARECOXIB |
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