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Gene: HSPE1 |
Gene summary for HSPE1 |
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Gene information | Species | Human | Gene symbol | HSPE1 | Gene ID | 3336 |
Gene name | heat shock protein family E (Hsp10) member 1 | |
Gene Alias | CPN10 | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0001503 | UniProtAcc | P61604 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3336 | HSPE1 | GSM4909277 | Human | Breast | Precancer | 4.55e-13 | 8.38e-01 | 0.0177 |
3336 | HSPE1 | GSM4909280 | Human | Breast | Precancer | 8.21e-03 | 2.93e-01 | 0.0305 |
3336 | HSPE1 | GSM4909281 | Human | Breast | IDC | 1.03e-06 | 3.51e-01 | 0.21 |
3336 | HSPE1 | GSM4909285 | Human | Breast | IDC | 8.01e-19 | 4.79e-01 | 0.21 |
3336 | HSPE1 | GSM4909286 | Human | Breast | IDC | 6.96e-11 | -6.10e-02 | 0.1081 |
3336 | HSPE1 | GSM4909287 | Human | Breast | IDC | 1.00e-18 | 4.94e-01 | 0.2057 |
3336 | HSPE1 | GSM4909293 | Human | Breast | IDC | 3.46e-04 | 1.54e-01 | 0.1581 |
3336 | HSPE1 | GSM4909294 | Human | Breast | IDC | 1.67e-39 | 5.45e-01 | 0.2022 |
3336 | HSPE1 | GSM4909296 | Human | Breast | IDC | 1.96e-02 | 7.43e-02 | 0.1524 |
3336 | HSPE1 | GSM4909297 | Human | Breast | IDC | 1.50e-09 | -9.32e-02 | 0.1517 |
3336 | HSPE1 | GSM4909298 | Human | Breast | IDC | 5.00e-08 | -2.01e-01 | 0.1551 |
3336 | HSPE1 | GSM4909304 | Human | Breast | IDC | 6.28e-08 | 2.96e-01 | 0.1636 |
3336 | HSPE1 | GSM4909308 | Human | Breast | IDC | 6.36e-07 | 2.42e-01 | 0.158 |
3336 | HSPE1 | GSM4909311 | Human | Breast | IDC | 6.34e-31 | -5.82e-01 | 0.1534 |
3336 | HSPE1 | GSM4909312 | Human | Breast | IDC | 6.03e-06 | -2.64e-01 | 0.1552 |
3336 | HSPE1 | GSM4909313 | Human | Breast | IDC | 5.41e-09 | -5.14e-01 | 0.0391 |
3336 | HSPE1 | GSM4909315 | Human | Breast | IDC | 2.43e-05 | 2.88e-01 | 0.21 |
3336 | HSPE1 | GSM4909316 | Human | Breast | IDC | 3.25e-06 | 4.01e-01 | 0.21 |
3336 | HSPE1 | GSM4909319 | Human | Breast | IDC | 1.15e-43 | -3.08e-01 | 0.1563 |
3336 | HSPE1 | GSM4909320 | Human | Breast | IDC | 9.88e-05 | -2.88e-01 | 0.1575 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200011633 | Thyroid | ATC | regulation of cysteine-type endopeptidase activity | 111/6293 | 235/18723 | 9.41e-06 | 9.41e-05 | 111 |
GO:000645833 | Thyroid | ATC | 'de novo' protein folding | 28/6293 | 43/18723 | 2.35e-05 | 2.06e-04 | 28 |
GO:001095233 | Thyroid | ATC | positive regulation of peptidase activity | 94/6293 | 197/18723 | 2.67e-05 | 2.28e-04 | 94 |
GO:005108433 | Thyroid | ATC | 'de novo' posttranslational protein folding | 25/6293 | 39/18723 | 9.45e-05 | 6.91e-04 | 25 |
GO:005254834 | Thyroid | ATC | regulation of endopeptidase activity | 181/6293 | 432/18723 | 1.70e-04 | 1.16e-03 | 181 |
GO:005108533 | Thyroid | ATC | chaperone cofactor-dependent protein refolding | 22/6293 | 34/18723 | 2.03e-04 | 1.35e-03 | 22 |
GO:001095033 | Thyroid | ATC | positive regulation of endopeptidase activity | 79/6293 | 179/18723 | 2.09e-03 | 9.86e-03 | 79 |
GO:004328031 | Thyroid | ATC | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 58/6293 | 129/18723 | 4.70e-03 | 1.93e-02 | 58 |
GO:200105632 | Thyroid | ATC | positive regulation of cysteine-type endopeptidase activity | 64/6293 | 148/18723 | 8.98e-03 | 3.39e-02 | 64 |
GO:000691922 | Thyroid | ATC | activation of cysteine-type endopeptidase activity involved in apoptotic process | 36/6293 | 78/18723 | 1.43e-02 | 4.92e-02 | 36 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPE1 | SNV | Missense_Mutation | c.4N>A | p.Ala2Thr | p.A2T | P61604 | protein_coding | deleterious(0.05) | benign(0.027) | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
HSPE1 | SNV | Missense_Mutation | c.175N>A | p.Glu59Lys | p.E59K | P61604 | protein_coding | tolerated(0.45) | benign(0.019) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HSPE1 | SNV | Missense_Mutation | novel | c.212N>C | p.Val71Ala | p.V71A | P61604 | protein_coding | deleterious(0) | possibly_damaging(0.741) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
HSPE1 | SNV | Missense_Mutation | novel | c.203N>C | p.Gly68Ala | p.G68A | P61604 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-P3-A5QF-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cetuximab | PD |
HSPE1 | SNV | Missense_Mutation | novel | c.70G>A | p.Glu24Lys | p.E24K | P61604 | protein_coding | tolerated(0.28) | benign(0.053) | TCGA-T2-A6WZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cetuximab | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3336 | HSPE1 | NA | XToll |
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