GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19054752 | Colorectum | MSS | regulation of protein localization to membrane | 68/3467 | 175/18723 | 2.16e-10 | 2.09e-08 | 68 |
GO:19013612 | Colorectum | MSS | organic cyclic compound catabolic process | 148/3467 | 495/18723 | 3.47e-10 | 3.18e-08 | 148 |
GO:19029032 | Colorectum | MSS | regulation of supramolecular fiber organization | 121/3467 | 383/18723 | 3.63e-10 | 3.28e-08 | 121 |
GO:00434872 | Colorectum | MSS | regulation of RNA stability | 66/3467 | 170/18723 | 4.14e-10 | 3.49e-08 | 66 |
GO:00431612 | Colorectum | MSS | proteasome-mediated ubiquitin-dependent protein catabolic process | 127/3467 | 412/18723 | 7.70e-10 | 6.32e-08 | 127 |
GO:00434882 | Colorectum | MSS | regulation of mRNA stability | 62/3467 | 158/18723 | 8.41e-10 | 6.81e-08 | 62 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:00329562 | Colorectum | MSS | regulation of actin cytoskeleton organization | 113/3467 | 358/18723 | 1.46e-09 | 1.07e-07 | 113 |
GO:19029052 | Colorectum | MSS | positive regulation of supramolecular fiber organization | 75/3467 | 209/18723 | 1.89e-09 | 1.35e-07 | 75 |
GO:01100532 | Colorectum | MSS | regulation of actin filament organization | 92/3467 | 278/18723 | 3.61e-09 | 2.42e-07 | 92 |
GO:19030762 | Colorectum | MSS | regulation of protein localization to plasma membrane | 45/3467 | 104/18723 | 4.82e-09 | 3.17e-07 | 45 |
GO:19043752 | Colorectum | MSS | regulation of protein localization to cell periphery | 51/3467 | 125/18723 | 5.46e-09 | 3.55e-07 | 51 |
GO:00514952 | Colorectum | MSS | positive regulation of cytoskeleton organization | 78/3467 | 226/18723 | 6.86e-09 | 4.32e-07 | 78 |
GO:00903162 | Colorectum | MSS | positive regulation of intracellular protein transport | 60/3467 | 160/18723 | 1.18e-08 | 7.08e-07 | 60 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00021832 | Colorectum | MSS | cytoplasmic translational initiation | 21/3467 | 34/18723 | 2.99e-08 | 1.67e-06 | 21 |
GO:00323882 | Colorectum | MSS | positive regulation of intracellular transport | 70/3467 | 202/18723 | 3.32e-08 | 1.82e-06 | 70 |
GO:00064172 | Colorectum | MSS | regulation of translation | 134/3467 | 468/18723 | 4.43e-08 | 2.38e-06 | 134 |
GO:00064032 | Colorectum | MSS | RNA localization | 69/3467 | 201/18723 | 6.33e-08 | 3.26e-06 | 69 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
F5 | SNV | Missense_Mutation | novel | c.4241N>T | p.Asp1414Val | p.D1414V | P12259 | protein_coding | deleterious_low_confidence(0.04) | benign(0.209) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | novel | c.3913N>G | p.Pro1305Ala | p.P1305A | P12259 | protein_coding | deleterious_low_confidence(0.03) | benign(0.265) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | novel | c.1495C>A | p.Gln499Lys | p.Q499K | P12259 | protein_coding | deleterious(0.02) | possibly_damaging(0.541) | TCGA-A7-A0DB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
F5 | SNV | Missense_Mutation | | c.6397N>T | p.Ile2133Leu | p.I2133L | P12259 | protein_coding | deleterious(0.02) | possibly_damaging(0.622) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | | c.6396N>T | p.Lys2132Asn | p.K2132N | P12259 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A07L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | | CR |
F5 | SNV | Missense_Mutation | novel | c.4087N>A | p.His1363Asn | p.H1363N | P12259 | protein_coding | tolerated_low_confidence(0.14) | benign(0.023) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | novel | c.4086N>A | p.Ser1362Arg | p.S1362R | P12259 | protein_coding | tolerated_low_confidence(0.09) | benign(0.168) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | | c.622G>C | p.Asp208His | p.D208H | P12259 | protein_coding | tolerated(0.13) | benign(0.123) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
F5 | SNV | Missense_Mutation | | c.1447N>A | p.Tyr483Asn | p.Y483N | P12259 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
F5 | SNV | Missense_Mutation | novel | c.5676N>C | p.Gln1892His | p.Q1892H | P12259 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2153 | F5 | DRUGGABLE GENOME | | drotrecogin alfa | | 15118525 |
2153 | F5 | DRUGGABLE GENOME | | rivaroxaban | RIVAROXABAN | |
2153 | F5 | DRUGGABLE GENOME | | Rivaroxaban | RIVAROXABAN | |
2153 | F5 | DRUGGABLE GENOME | | estrogens | ESTRONE SODIUM SULFATE | 11532625,16113779,12067913,12869355,16301339,9459317,10073976,15467059,11859850,10943572,12069454,12138364,14551147,7968118,11703344 |
2153 | F5 | DRUGGABLE GENOME | | Drotrecogin alfa | | |
2153 | F5 | DRUGGABLE GENOME | | Eltrombopag | ELTROMBOPAG | |
2153 | F5 | DRUGGABLE GENOME | | DROTRECOGIN ALFA | | |
2153 | F5 | DRUGGABLE GENOME | | hormonal contraceptives for systemic use | | 11532625,16113779,15208046,15946211,12869355,16301339,9459317,10073976,15467059,11859850,10943572,12069454,16769590,12138364,14551147,7968118 |
2153 | F5 | DRUGGABLE GENOME | inhibitor | CHEMBL2109065 | DROTRECOGIN ALFA (ACTIVATED) | |
2153 | F5 | DRUGGABLE GENOME | | THROMBIN | THROMBIN | |