Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: EPS8

Gene summary for EPS8

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

EPS8

Gene ID

2059

Gene nameepidermal growth factor receptor pathway substrate 8
Gene AliasDFNB102
Cytomap12p12.3
Gene Typeprotein-coding
GO ID

GO:0000278

UniProtAcc

B4E3T6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
2059EPS8HTA11_3410_2000001011HumanColorectumAD7.86e-43-1.07e+000.0155
2059EPS8HTA11_2951_2000001011HumanColorectumAD1.06e-03-8.33e-010.0216
2059EPS8HTA11_3361_2000001011HumanColorectumAD5.36e-21-1.03e+00-0.1207
2059EPS8HTA11_83_2000001011HumanColorectumSER5.83e-08-5.93e-01-0.1526
2059EPS8HTA11_696_2000001011HumanColorectumAD9.16e-33-5.86e-01-0.1464
2059EPS8HTA11_866_2000001011HumanColorectumAD2.63e-16-5.56e-01-0.1001
2059EPS8HTA11_1391_2000001011HumanColorectumAD4.43e-04-5.49e-01-0.059
2059EPS8HTA11_5212_2000001011HumanColorectumAD9.94e-03-5.51e-01-0.2061
2059EPS8HTA11_546_2000001011HumanColorectumAD3.92e-03-6.16e-01-0.0842
2059EPS8HTA11_9341_2000001011HumanColorectumSER6.34e-05-1.12e+00-0.00410000000000005
2059EPS8HTA11_7862_2000001011HumanColorectumAD1.20e-06-5.79e-01-0.0179
2059EPS8HTA11_866_3004761011HumanColorectumAD1.58e-10-7.09e-010.096
2059EPS8HTA11_4255_2000001011HumanColorectumSER2.26e-04-9.36e-010.0446
2059EPS8HTA11_9408_2000001011HumanColorectumAD1.84e-02-8.31e-010.0451
2059EPS8HTA11_8622_2000001021HumanColorectumSER5.74e-08-1.01e+000.0528
2059EPS8HTA11_7663_2000001011HumanColorectumSER4.92e-03-6.52e-010.0131
2059EPS8HTA11_10623_2000001011HumanColorectumAD4.23e-03-5.79e-01-0.0177
2059EPS8HTA11_6801_2000001011HumanColorectumSER3.65e-02-8.03e-010.0171
2059EPS8HTA11_10711_2000001011HumanColorectumAD2.97e-18-8.78e-010.0338
2059EPS8HTA11_7696_3000711011HumanColorectumAD1.96e-23-6.52e-010.0674
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:009730523LungMIACresponse to alcohol25/967253/187231.47e-032.55e-0225
GO:003083323LungMIACregulation of actin filament polymerization19/967172/187231.47e-032.55e-0219
GO:003004113LungMIACactin filament polymerization20/967191/187232.13e-033.33e-0220
GO:012003221LungMIACregulation of plasma membrane bounded cell projection assembly19/967186/187233.58e-034.56e-0219
GO:00080648LungMIACregulation of actin polymerization or depolymerization19/967188/187234.03e-034.84e-0219
GO:006049121LungMIACregulation of cell projection assembly19/967188/187234.03e-034.84e-0219
GO:002241119Oral cavityOSCCcellular component disassembly283/7305443/187239.57e-273.37e-24283
GO:01400145Oral cavityOSCCmitotic nuclear division191/7305287/187231.99e-213.70e-19191
GO:00447728Oral cavityOSCCmitotic cell cycle phase transition255/7305424/187235.29e-196.98e-17255
GO:004325420Oral cavityOSCCregulation of protein-containing complex assembly255/7305428/187232.94e-183.15e-16255
GO:00482852Oral cavityOSCCorganelle fission265/7305488/187233.22e-121.27e-10265
GO:003298410Oral cavityOSCCprotein-containing complex disassembly136/7305224/187233.42e-111.13e-09136
GO:190290320Oral cavityOSCCregulation of supramolecular fiber organization211/7305383/187239.45e-112.88e-09211
GO:00002801Oral cavityOSCCnuclear division237/7305439/187239.62e-112.90e-09237
GO:005125820Oral cavityOSCCprotein polymerization169/7305297/187232.57e-107.17e-09169
GO:00072659Oral cavityOSCCRas protein signal transduction185/7305337/187231.95e-094.60e-08185
GO:001063918Oral cavityOSCCnegative regulation of organelle organization190/7305348/187232.12e-094.97e-08190
GO:003227120Oral cavityOSCCregulation of protein polymerization134/7305233/187237.20e-091.51e-07134
GO:000701520Oral cavityOSCCactin filament organization230/7305442/187231.37e-082.77e-07230
GO:003297020Oral cavityOSCCregulation of actin filament-based process209/7305397/187231.89e-083.72e-07209
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
EPS8SNVMissense_Mutationc.982N>Cp.Phe328Leup.F328LQ12929protein_codingtolerated(0.05)possibly_damaging(0.533)TCGA-A8-A09Z-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
EPS8SNVMissense_Mutationc.1785G>Tp.Leu595Phep.L595FQ12929protein_codingtolerated(0.32)benign(0.003)TCGA-AO-A0JC-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilSD
EPS8SNVMissense_Mutationc.1508A>Gp.His503Argp.H503RQ12929protein_codingtolerated(0.35)benign(0)TCGA-AQ-A04H-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapytaxotereSD
EPS8SNVMissense_Mutationc.220N>Tp.Val74Phep.V74FQ12929protein_codingdeleterious(0)possibly_damaging(0.57)TCGA-B6-A0RP-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
EPS8SNVMissense_Mutationrs776013800c.287C>Gp.Ala96Glyp.A96GQ12929protein_codingdeleterious(0.01)possibly_damaging(0.574)TCGA-C8-A26Y-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
EPS8SNVMissense_Mutationrs369986759c.794N>Ap.Arg265Hisp.R265HQ12929protein_codingdeleterious(0)benign(0.097)TCGA-D8-A1J8-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapynolvadexSD
EPS8SNVMissense_Mutationc.1313A>Tp.Glu438Valp.E438VQ12929protein_codingdeleterious(0)possibly_damaging(0.459)TCGA-E9-A22G-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
EPS8insertionFrame_Shift_Insnovelc.2371_2372insTTGCTGTTTTAGGTAGTATGGCCATTTTCACp.Ser791PhefsTer29p.S791Ffs*29Q12929protein_codingTCGA-A2-A0EY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
EPS8SNVMissense_Mutationrs147224631c.1300N>Tp.Arg434Cysp.R434CQ12929protein_codingdeleterious(0)benign(0.125)TCGA-EA-A410-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
EPS8SNVMissense_Mutationc.1499N>Cp.Arg500Thrp.R500TQ12929protein_codingtolerated(0.08)benign(0.024)TCGA-EK-A2RJ-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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