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Gene: ZNF335 |
Gene summary for ZNF335 |
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Gene information | Species | Human | Gene symbol | ZNF335 | Gene ID | 63925 |
Gene name | zinc finger protein 335 | |
Gene Alias | MCPH10 | |
Cytomap | 20q13.12 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8IW09 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63925 | ZNF335 | LZE4T | Human | Esophagus | ESCC | 5.94e-08 | 2.84e-01 | 0.0811 |
63925 | ZNF335 | LZE7T | Human | Esophagus | ESCC | 8.30e-06 | 3.70e-01 | 0.0667 |
63925 | ZNF335 | LZE8T | Human | Esophagus | ESCC | 1.24e-02 | 1.72e-01 | 0.067 |
63925 | ZNF335 | LZE20T | Human | Esophagus | ESCC | 4.91e-06 | 2.41e-01 | 0.0662 |
63925 | ZNF335 | LZE24T | Human | Esophagus | ESCC | 5.64e-04 | 2.31e-01 | 0.0596 |
63925 | ZNF335 | LZE21T | Human | Esophagus | ESCC | 7.07e-03 | 3.26e-01 | 0.0655 |
63925 | ZNF335 | P1T-E | Human | Esophagus | ESCC | 2.74e-12 | 6.63e-01 | 0.0875 |
63925 | ZNF335 | P2T-E | Human | Esophagus | ESCC | 4.97e-20 | 2.45e-01 | 0.1177 |
63925 | ZNF335 | P5T-E | Human | Esophagus | ESCC | 4.65e-10 | 1.30e-01 | 0.1327 |
63925 | ZNF335 | P8T-E | Human | Esophagus | ESCC | 8.68e-16 | 2.38e-01 | 0.0889 |
63925 | ZNF335 | P9T-E | Human | Esophagus | ESCC | 6.30e-09 | 2.77e-01 | 0.1131 |
63925 | ZNF335 | P10T-E | Human | Esophagus | ESCC | 1.11e-27 | 4.32e-01 | 0.116 |
63925 | ZNF335 | P11T-E | Human | Esophagus | ESCC | 3.45e-07 | 4.29e-01 | 0.1426 |
63925 | ZNF335 | P12T-E | Human | Esophagus | ESCC | 2.80e-17 | 3.12e-01 | 0.1122 |
63925 | ZNF335 | P15T-E | Human | Esophagus | ESCC | 1.66e-19 | 3.97e-01 | 0.1149 |
63925 | ZNF335 | P16T-E | Human | Esophagus | ESCC | 4.53e-11 | 2.23e-01 | 0.1153 |
63925 | ZNF335 | P20T-E | Human | Esophagus | ESCC | 2.72e-27 | 7.48e-01 | 0.1124 |
63925 | ZNF335 | P21T-E | Human | Esophagus | ESCC | 4.86e-15 | 3.27e-01 | 0.1617 |
63925 | ZNF335 | P22T-E | Human | Esophagus | ESCC | 5.36e-09 | 8.37e-02 | 0.1236 |
63925 | ZNF335 | P23T-E | Human | Esophagus | ESCC | 2.27e-10 | 3.08e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001820513 | Oral cavity | LP | peptidyl-lysine modification | 136/4623 | 376/18723 | 3.64e-07 | 1.06e-05 | 136 |
GO:001657014 | Oral cavity | LP | histone modification | 152/4623 | 463/18723 | 4.04e-05 | 5.90e-04 | 152 |
GO:003105613 | Oral cavity | LP | regulation of histone modification | 55/4623 | 152/18723 | 1.01e-03 | 8.48e-03 | 55 |
GO:004002911 | Oral cavity | LP | regulation of gene expression, epigenetic | 39/4623 | 105/18723 | 3.00e-03 | 2.05e-02 | 39 |
GO:001072014 | Oral cavity | LP | positive regulation of cell development | 93/4623 | 298/18723 | 6.07e-03 | 3.60e-02 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ZNF335 | MYOFIB | Colorectum | AD | SUMO1,PDE1B,ABHD13, etc. | 7.85e-02 | ![]() |
ZNF335 | CYC | Skin | Healthy | KCNQ1OT1,EVPL,PLCG2, etc. | 1.06e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF335 | SNV | Missense_Mutation | novel | c.2574N>C | p.Glu858Asp | p.E858D | Q9H4Z2 | protein_coding | deleterious(0.01) | benign(0.225) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
ZNF335 | SNV | Missense_Mutation | novel | c.3777N>A | p.His1259Gln | p.H1259Q | Q9H4Z2 | protein_coding | tolerated(0.09) | probably_damaging(0.917) | TCGA-A2-A1G1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF335 | SNV | Missense_Mutation | rs555774487 | c.1856N>A | p.Arg619His | p.R619H | Q9H4Z2 | protein_coding | deleterious(0.03) | possibly_damaging(0.813) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF335 | SNV | Missense_Mutation | c.2174N>G | p.Ser725Cys | p.S725C | Q9H4Z2 | protein_coding | deleterious(0) | possibly_damaging(0.818) | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
ZNF335 | SNV | Missense_Mutation | novel | c.356N>C | p.Val119Ala | p.V119A | Q9H4Z2 | protein_coding | deleterious(0.01) | benign(0.001) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
ZNF335 | SNV | Missense_Mutation | novel | c.985G>A | p.Glu329Lys | p.E329K | Q9H4Z2 | protein_coding | deleterious(0.01) | possibly_damaging(0.681) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
ZNF335 | insertion | Frame_Shift_Ins | novel | c.3972_3973insGAGGTGAGGACTTGGGGACAGGCAGGGAGGGGAGC | p.Gln1325GlufsTer60 | p.Q1325Efs*60 | Q9H4Z2 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
ZNF335 | SNV | Missense_Mutation | novel | c.1844N>A | p.Ala615Asp | p.A615D | Q9H4Z2 | protein_coding | deleterious(0.02) | benign(0.116) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF335 | SNV | Missense_Mutation | novel | c.1372N>T | p.Pro458Ser | p.P458S | Q9H4Z2 | protein_coding | tolerated(0.24) | possibly_damaging(0.715) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF335 | SNV | Missense_Mutation | rs767339054 | c.3964N>A | p.Glu1322Lys | p.E1322K | Q9H4Z2 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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