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Gene: ZGPAT |
Gene summary for ZGPAT |
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Gene information | Species | Human | Gene symbol | ZGPAT | Gene ID | 84619 |
Gene name | zinc finger CCCH-type and G-patch domain containing | |
Gene Alias | GPATC6 | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A0S2Z5X3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84619 | ZGPAT | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 4.66e-01 | 0.082 |
84619 | ZGPAT | LZE4T | Human | Esophagus | ESCC | 1.39e-13 | 3.54e-01 | 0.0811 |
84619 | ZGPAT | LZE7T | Human | Esophagus | ESCC | 1.16e-13 | 4.61e-01 | 0.0667 |
84619 | ZGPAT | LZE8T | Human | Esophagus | ESCC | 1.75e-09 | 2.76e-01 | 0.067 |
84619 | ZGPAT | LZE20T | Human | Esophagus | ESCC | 2.37e-09 | 2.92e-01 | 0.0662 |
84619 | ZGPAT | LZE22T | Human | Esophagus | ESCC | 5.52e-13 | 5.38e-01 | 0.068 |
84619 | ZGPAT | LZE24T | Human | Esophagus | ESCC | 2.47e-19 | 4.21e-01 | 0.0596 |
84619 | ZGPAT | LZE22D3 | Human | Esophagus | HGIN | 1.73e-02 | 5.15e-01 | 0.0653 |
84619 | ZGPAT | LZE6T | Human | Esophagus | ESCC | 2.61e-09 | 2.81e-01 | 0.0845 |
84619 | ZGPAT | P1T-E | Human | Esophagus | ESCC | 5.20e-08 | 3.48e-01 | 0.0875 |
84619 | ZGPAT | P2T-E | Human | Esophagus | ESCC | 9.74e-22 | 3.99e-01 | 0.1177 |
84619 | ZGPAT | P4T-E | Human | Esophagus | ESCC | 2.81e-13 | 2.92e-01 | 0.1323 |
84619 | ZGPAT | P5T-E | Human | Esophagus | ESCC | 1.23e-20 | 3.26e-01 | 0.1327 |
84619 | ZGPAT | P8T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.62e-01 | 0.0889 |
84619 | ZGPAT | P9T-E | Human | Esophagus | ESCC | 4.72e-09 | 2.08e-01 | 0.1131 |
84619 | ZGPAT | P10T-E | Human | Esophagus | ESCC | 6.31e-48 | 7.40e-01 | 0.116 |
84619 | ZGPAT | P11T-E | Human | Esophagus | ESCC | 1.06e-12 | 4.28e-01 | 0.1426 |
84619 | ZGPAT | P12T-E | Human | Esophagus | ESCC | 3.19e-23 | 4.30e-01 | 0.1122 |
84619 | ZGPAT | P15T-E | Human | Esophagus | ESCC | 4.29e-21 | 3.81e-01 | 0.1149 |
84619 | ZGPAT | P16T-E | Human | Esophagus | ESCC | 8.84e-36 | 5.62e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19011844 | Liver | HCC | regulation of ERBB signaling pathway | 47/7958 | 79/18723 | 1.71e-03 | 8.91e-03 | 47 |
GO:004205922 | Liver | HCC | negative regulation of epidermal growth factor receptor signaling pathway | 20/7958 | 28/18723 | 1.86e-03 | 9.50e-03 | 20 |
GO:00420584 | Liver | HCC | regulation of epidermal growth factor receptor signaling pathway | 43/7958 | 73/18723 | 3.43e-03 | 1.55e-02 | 43 |
GO:00610995 | Liver | HCC | negative regulation of protein tyrosine kinase activity | 20/7958 | 31/18723 | 1.11e-02 | 4.09e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZGPAT | SNV | Missense_Mutation | novel | c.677N>A | p.Ala226Asp | p.A226D | Q8N5A5 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
ZGPAT | SNV | Missense_Mutation | rs746868722 | c.1310C>T | p.Ala437Val | p.A437V | Q8N5A5 | protein_coding | tolerated(0.39) | benign(0.036) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZGPAT | SNV | Missense_Mutation | rs201544347 | c.226N>A | p.Asp76Asn | p.D76N | Q8N5A5 | protein_coding | deleterious(0.03) | benign(0.141) | TCGA-C8-A26V-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | CR |
ZGPAT | SNV | Missense_Mutation | novel | c.814G>A | p.Glu272Lys | p.E272K | Q8N5A5 | protein_coding | deleterious(0.01) | benign(0.293) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZGPAT | SNV | Missense_Mutation | novel | c.229G>T | p.Ala77Ser | p.A77S | Q8N5A5 | protein_coding | tolerated(0.68) | benign(0.114) | TCGA-E2-A570-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
ZGPAT | deletion | Frame_Shift_Del | novel | c.187delN | p.Leu63TrpfsTer67 | p.L63Wfs*67 | Q8N5A5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZGPAT | deletion | Frame_Shift_Del | novel | c.919delN | p.Pro307ArgfsTer30 | p.P307Rfs*30 | Q8N5A5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
ZGPAT | deletion | Frame_Shift_Del | novel | c.467delN | p.Glu157ArgfsTer21 | p.E157Rfs*21 | Q8N5A5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ZGPAT | SNV | Missense_Mutation | novel | c.1528N>C | p.Ala510Pro | p.A510P | Q8N5A5 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
ZGPAT | SNV | Missense_Mutation | novel | c.1529N>T | p.Ala510Val | p.A510V | Q8N5A5 | protein_coding | deleterious(0.01) | probably_damaging(0.949) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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