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Gene: WLS |
Gene summary for WLS |
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Gene information | Species | Human | Gene symbol | WLS | Gene ID | 79971 |
Gene name | Wnt ligand secretion mediator | |
Gene Alias | C1orf139 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0001704 | UniProtAcc | Q5T9L3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79971 | WLS | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.39e-13 | -5.05e-01 | 0.0155 |
79971 | WLS | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.91e-02 | -3.87e-01 | -0.1808 |
79971 | WLS | HTA11_347_2000001011 | Human | Colorectum | AD | 3.79e-03 | -1.09e-01 | -0.1954 |
79971 | WLS | HTA11_3361_2000001011 | Human | Colorectum | AD | 9.37e-03 | -4.45e-01 | -0.1207 |
79971 | WLS | HTA11_696_2000001011 | Human | Colorectum | AD | 2.83e-05 | -4.16e-01 | -0.1464 |
79971 | WLS | HTA11_866_2000001011 | Human | Colorectum | AD | 1.44e-06 | -4.46e-01 | -0.1001 |
79971 | WLS | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.52e-03 | -3.77e-01 | -0.059 |
79971 | WLS | HTA11_546_2000001011 | Human | Colorectum | AD | 3.69e-02 | -4.67e-01 | -0.0842 |
79971 | WLS | HTA11_866_3004761011 | Human | Colorectum | AD | 6.67e-06 | -4.02e-01 | 0.096 |
79971 | WLS | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.46e-02 | -4.00e-01 | 0.0338 |
79971 | WLS | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.10e-09 | -4.22e-01 | 0.0674 |
79971 | WLS | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.58e-05 | -3.78e-01 | 0.294 |
79971 | WLS | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.73e-02 | -3.56e-01 | 0.281 |
79971 | WLS | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.55e-05 | -5.54e-01 | 0.2585 |
79971 | WLS | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.64e-04 | -3.97e-01 | 0.3005 |
79971 | WLS | F007 | Human | Colorectum | FAP | 3.62e-03 | -2.30e-01 | 0.1176 |
79971 | WLS | A001-C-207 | Human | Colorectum | FAP | 5.84e-06 | -3.41e-01 | 0.1278 |
79971 | WLS | A015-C-203 | Human | Colorectum | FAP | 3.28e-13 | -3.93e-01 | -0.1294 |
79971 | WLS | A015-C-204 | Human | Colorectum | FAP | 1.41e-04 | -2.82e-01 | -0.0228 |
79971 | WLS | A002-C-201 | Human | Colorectum | FAP | 7.41e-15 | -4.46e-01 | 0.0324 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301112 | Colorectum | MSS | regulation of Wnt signaling pathway | 98/3467 | 328/18723 | 3.37e-07 | 1.36e-05 | 98 |
GO:00160552 | Colorectum | MSS | Wnt signaling pathway | 124/3467 | 444/18723 | 6.06e-07 | 2.26e-05 | 124 |
GO:01987382 | Colorectum | MSS | cell-cell signaling by wnt | 124/3467 | 446/18723 | 7.83e-07 | 2.77e-05 | 124 |
GO:00507082 | Colorectum | MSS | regulation of protein secretion | 78/3467 | 268/18723 | 1.47e-05 | 3.33e-04 | 78 |
GO:00600702 | Colorectum | MSS | canonical Wnt signaling pathway | 86/3467 | 303/18723 | 1.58e-05 | 3.56e-04 | 86 |
GO:00608282 | Colorectum | MSS | regulation of canonical Wnt signaling pathway | 74/3467 | 253/18723 | 1.99e-05 | 4.26e-04 | 74 |
GO:00093062 | Colorectum | MSS | protein secretion | 98/3467 | 359/18723 | 2.43e-05 | 5.09e-04 | 98 |
GO:00355922 | Colorectum | MSS | establishment of protein localization to extracellular region | 98/3467 | 360/18723 | 2.75e-05 | 5.58e-04 | 98 |
GO:00716922 | Colorectum | MSS | protein localization to extracellular region | 99/3467 | 368/18723 | 4.17e-05 | 7.83e-04 | 99 |
GO:00431221 | Colorectum | MSS | regulation of I-kappaB kinase/NF-kappaB signaling | 71/3467 | 249/18723 | 7.12e-05 | 1.21e-03 | 71 |
GO:00072491 | Colorectum | MSS | I-kappaB kinase/NF-kappaB signaling | 77/3467 | 281/18723 | 1.51e-04 | 2.19e-03 | 77 |
GO:00301771 | Colorectum | MSS | positive regulation of Wnt signaling pathway | 44/3467 | 140/18723 | 1.57e-04 | 2.28e-03 | 44 |
GO:00431231 | Colorectum | MSS | positive regulation of I-kappaB kinase/NF-kappaB signaling | 55/3467 | 186/18723 | 1.60e-04 | 2.29e-03 | 55 |
GO:00309012 | Colorectum | MSS | midbrain development | 31/3467 | 90/18723 | 2.36e-04 | 3.24e-03 | 31 |
GO:00507141 | Colorectum | MSS | positive regulation of protein secretion | 42/3467 | 137/18723 | 3.95e-04 | 4.91e-03 | 42 |
GO:19035321 | Colorectum | MSS | positive regulation of secretion by cell | 74/3467 | 282/18723 | 7.93e-04 | 8.36e-03 | 74 |
GO:00510472 | Colorectum | MSS | positive regulation of secretion | 80/3467 | 310/18723 | 8.55e-04 | 8.75e-03 | 80 |
GO:00902631 | Colorectum | MSS | positive regulation of canonical Wnt signaling pathway | 32/3467 | 106/18723 | 2.41e-03 | 1.96e-02 | 32 |
GO:19049514 | Colorectum | FAP | positive regulation of establishment of protein localization | 82/2622 | 319/18723 | 1.83e-08 | 1.87e-06 | 82 |
GO:00487324 | Colorectum | FAP | gland development | 103/2622 | 436/18723 | 3.61e-08 | 3.12e-06 | 103 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WLS | SNV | Missense_Mutation | novel | c.1484A>C | p.Lys495Thr | p.K495T | Q5T9L3 | protein_coding | deleterious(0.03) | probably_damaging(0.921) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WLS | SNV | Missense_Mutation | c.473N>C | p.Leu158Pro | p.L158P | Q5T9L3 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AR-A251-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
WLS | SNV | Missense_Mutation | c.466N>G | p.Arg156Gly | p.R156G | Q5T9L3 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BH-A0AY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | SD | ||
WLS | SNV | Missense_Mutation | c.440C>T | p.Thr147Ile | p.T147I | Q5T9L3 | protein_coding | tolerated(0.07) | possibly_damaging(0.812) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WLS | SNV | Missense_Mutation | c.376N>C | p.Glu126Gln | p.E126Q | Q5T9L3 | protein_coding | tolerated(0.3) | benign(0.071) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
WLS | SNV | Missense_Mutation | c.416N>A | p.Arg139His | p.R139H | Q5T9L3 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-E2-A15D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
WLS | SNV | Missense_Mutation | c.1064N>A | p.Arg355Lys | p.R355K | Q5T9L3 | protein_coding | deleterious(0.05) | probably_damaging(0.972) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
WLS | SNV | Missense_Mutation | rs368075278 | c.154N>T | p.Arg52Cys | p.R52C | Q5T9L3 | protein_coding | tolerated(0.05) | benign(0.34) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WLS | SNV | Missense_Mutation | c.449N>T | p.Ala150Val | p.A150V | Q5T9L3 | protein_coding | tolerated(0.1) | benign(0.225) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WLS | SNV | Missense_Mutation | c.152C>T | p.Ala51Val | p.A51V | Q5T9L3 | protein_coding | tolerated(0.3) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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