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Gene: WIPI1 |
Gene summary for WIPI1 |
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Gene information | Species | Human | Gene symbol | WIPI1 | Gene ID | 55062 |
Gene name | WD repeat domain, phosphoinositide interacting 1 | |
Gene Alias | ATG18 | |
Cytomap | 17q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | B4DX63 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55062 | WIPI1 | GSM4909293 | Human | Breast | IDC | 5.16e-10 | 3.04e-01 | 0.1581 |
55062 | WIPI1 | GSM4909294 | Human | Breast | IDC | 4.15e-03 | -1.44e-01 | 0.2022 |
55062 | WIPI1 | GSM4909296 | Human | Breast | IDC | 1.38e-03 | -1.69e-01 | 0.1524 |
55062 | WIPI1 | GSM4909297 | Human | Breast | IDC | 1.09e-03 | -1.13e-01 | 0.1517 |
55062 | WIPI1 | GSM4909298 | Human | Breast | IDC | 3.15e-21 | 5.01e-01 | 0.1551 |
55062 | WIPI1 | GSM4909311 | Human | Breast | IDC | 4.49e-09 | -1.47e-01 | 0.1534 |
55062 | WIPI1 | GSM4909312 | Human | Breast | IDC | 3.29e-02 | 7.18e-02 | 0.1552 |
55062 | WIPI1 | GSM4909319 | Human | Breast | IDC | 4.55e-09 | -1.79e-01 | 0.1563 |
55062 | WIPI1 | GSM4909321 | Human | Breast | IDC | 1.99e-04 | -8.02e-02 | 0.1559 |
55062 | WIPI1 | brca3 | Human | Breast | Precancer | 5.26e-04 | 2.51e-01 | -0.0263 |
55062 | WIPI1 | NCCBC2 | Human | Breast | DCIS | 3.79e-10 | 6.20e-01 | 0.1554 |
55062 | WIPI1 | NCCBC5 | Human | Breast | DCIS | 3.88e-04 | -1.62e-01 | 0.2046 |
55062 | WIPI1 | DCIS2 | Human | Breast | DCIS | 1.15e-30 | 1.04e-01 | 0.0085 |
55062 | WIPI1 | LZE4T | Human | Esophagus | ESCC | 1.27e-07 | 3.80e-01 | 0.0811 |
55062 | WIPI1 | LZE5T | Human | Esophagus | ESCC | 2.89e-06 | 6.77e-01 | 0.0514 |
55062 | WIPI1 | LZE7T | Human | Esophagus | ESCC | 9.35e-07 | 2.58e-01 | 0.0667 |
55062 | WIPI1 | LZE22T | Human | Esophagus | ESCC | 3.46e-02 | 1.62e-01 | 0.068 |
55062 | WIPI1 | LZE24T | Human | Esophagus | ESCC | 9.27e-45 | 1.94e+00 | 0.0596 |
55062 | WIPI1 | LZE21T | Human | Esophagus | ESCC | 9.53e-06 | 3.89e-01 | 0.0655 |
55062 | WIPI1 | P2T-E | Human | Esophagus | ESCC | 3.72e-10 | 8.70e-02 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009267110 | Esophagus | ESCC | cellular response to starvation | 110/8552 | 156/18723 | 2.63e-10 | 7.37e-09 | 110 |
GO:004259419 | Esophagus | ESCC | response to starvation | 133/8552 | 197/18723 | 4.31e-10 | 1.14e-08 | 133 |
GO:000042217 | Esophagus | ESCC | autophagy of mitochondrion | 63/8552 | 81/18723 | 3.41e-09 | 7.24e-08 | 63 |
GO:006172617 | Esophagus | ESCC | mitochondrion disassembly | 63/8552 | 81/18723 | 3.41e-09 | 7.24e-08 | 63 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
GO:00069038 | Esophagus | ESCC | vesicle targeting | 38/8552 | 45/18723 | 8.42e-08 | 1.43e-06 | 38 |
GO:190503712 | Esophagus | ESCC | autophagosome organization | 73/8552 | 103/18723 | 1.88e-07 | 2.93e-06 | 73 |
GO:000004513 | Esophagus | ESCC | autophagosome assembly | 69/8552 | 99/18723 | 1.10e-06 | 1.38e-05 | 69 |
GO:00421573 | Esophagus | ESCC | lipoprotein metabolic process | 86/8552 | 135/18723 | 1.78e-05 | 1.57e-04 | 86 |
GO:00064973 | Esophagus | ESCC | protein lipidation | 62/8552 | 92/18723 | 2.08e-05 | 1.80e-04 | 62 |
GO:004819914 | Esophagus | ESCC | vesicle targeting, to, from or within Golgi | 19/8552 | 21/18723 | 2.28e-05 | 1.96e-04 | 19 |
GO:00421583 | Esophagus | ESCC | lipoprotein biosynthetic process | 64/8552 | 96/18723 | 2.61e-05 | 2.20e-04 | 64 |
GO:00068953 | Esophagus | ESCC | Golgi to endosome transport | 13/8552 | 17/18723 | 1.00e-02 | 3.42e-02 | 13 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
GO:00224117 | Liver | Cirrhotic | cellular component disassembly | 182/4634 | 443/18723 | 1.59e-14 | 1.54e-12 | 182 |
GO:001623611 | Liver | Cirrhotic | macroautophagy | 129/4634 | 291/18723 | 1.75e-13 | 1.41e-11 | 129 |
GO:19030084 | Liver | Cirrhotic | organelle disassembly | 59/4634 | 114/18723 | 4.82e-10 | 2.27e-08 | 59 |
GO:004259412 | Liver | Cirrhotic | response to starvation | 87/4634 | 197/18723 | 1.85e-09 | 7.78e-08 | 87 |
GO:003166712 | Liver | Cirrhotic | response to nutrient levels | 174/4634 | 474/18723 | 3.08e-09 | 1.27e-07 | 174 |
GO:00070332 | Liver | Cirrhotic | vacuole organization | 80/4634 | 180/18723 | 5.73e-09 | 2.25e-07 | 80 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0513118 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0501714 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0513119 | Breast | Precancer | Shigellosis | 44/684 | 247/8465 | 3.91e-07 | 6.86e-06 | 5.26e-06 | 44 |
hsa0501715 | Breast | Precancer | Spinocerebellar ataxia | 29/684 | 143/8465 | 2.79e-06 | 3.83e-05 | 2.94e-05 | 29 |
hsa0501623 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0501023 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0501423 | Breast | IDC | Amyotrophic lateral sclerosis | 102/867 | 364/8465 | 1.29e-22 | 5.22e-21 | 3.91e-21 | 102 |
hsa0502223 | Breast | IDC | Pathways of neurodegeneration - multiple diseases | 116/867 | 476/8465 | 3.63e-20 | 1.18e-18 | 8.82e-19 | 116 |
hsa0513124 | Breast | IDC | Shigellosis | 47/867 | 247/8465 | 1.78e-05 | 2.00e-04 | 1.49e-04 | 47 |
hsa0501633 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0501033 | Breast | IDC | Alzheimer disease | 107/867 | 384/8465 | 1.70e-23 | 7.88e-22 | 5.90e-22 | 107 |
hsa0501433 | Breast | IDC | Amyotrophic lateral sclerosis | 102/867 | 364/8465 | 1.29e-22 | 5.22e-21 | 3.91e-21 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WIPI1 | SNV | Missense_Mutation | rs771913875 | c.937N>A | p.Gly313Arg | p.G313R | Q5MNZ9 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
WIPI1 | SNV | Missense_Mutation | c.652N>A | p.Asp218Asn | p.D218N | Q5MNZ9 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WIPI1 | insertion | Frame_Shift_Ins | novel | c.1207_1208insTGAGCTTCAGTCAAAACATCCCAGATAGTCAACCTGAAATCATT | p.Gly403ValfsTer45 | p.G403Vfs*45 | Q5MNZ9 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
WIPI1 | insertion | Frame_Shift_Ins | novel | c.1193_1194insCACC | p.Tyr399ThrfsTer4 | p.Y399Tfs*4 | Q5MNZ9 | protein_coding | TCGA-B6-A0I9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
WIPI1 | insertion | Nonsense_Mutation | novel | c.1193-1_1193insCTTGACCCTCACTTACCTGCAGCTCTGGCCGGCAGACCC | p.Gly398delinsAlaTerProSerLeuThrCysSerSerGlyArgGlnThrArg | p.G398delinsA*PSLTCSSGRQTR | Q5MNZ9 | protein_coding | TCGA-B6-A0I9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
WIPI1 | deletion | Frame_Shift_Del | c.1069delN | p.His357ThrfsTer29 | p.H357Tfs*29 | Q5MNZ9 | protein_coding | TCGA-E9-A1R5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
WIPI1 | SNV | Missense_Mutation | rs554506311 | c.922N>T | p.Arg308Cys | p.R308C | Q5MNZ9 | protein_coding | deleterious(0.03) | possibly_damaging(0.886) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WIPI1 | deletion | Frame_Shift_Del | novel | c.505delN | p.Val169CysfsTer8 | p.V169Cfs*8 | Q5MNZ9 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
WIPI1 | SNV | Missense_Mutation | rs200972573 | c.1184N>T | p.Thr395Met | p.T395M | Q5MNZ9 | protein_coding | deleterious(0.03) | benign(0.029) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WIPI1 | SNV | Missense_Mutation | c.224N>A | p.Val75Asp | p.V75D | Q5MNZ9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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