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Gene: WDR3 |
Gene summary for WDR3 |
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Gene information | Species | Human | Gene symbol | WDR3 | Gene ID | 10885 |
Gene name | WD repeat domain 3 | |
Gene Alias | DIP2 | |
Cytomap | 1p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5TDG3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10885 | WDR3 | LZE4T | Human | Esophagus | ESCC | 3.47e-05 | 1.06e-01 | 0.0811 |
10885 | WDR3 | LZE7T | Human | Esophagus | ESCC | 1.63e-02 | 1.43e-01 | 0.0667 |
10885 | WDR3 | LZE24T | Human | Esophagus | ESCC | 7.35e-05 | 1.06e-01 | 0.0596 |
10885 | WDR3 | P1T-E | Human | Esophagus | ESCC | 4.02e-03 | 1.89e-01 | 0.0875 |
10885 | WDR3 | P2T-E | Human | Esophagus | ESCC | 7.46e-14 | 2.61e-01 | 0.1177 |
10885 | WDR3 | P4T-E | Human | Esophagus | ESCC | 9.87e-13 | 3.09e-01 | 0.1323 |
10885 | WDR3 | P5T-E | Human | Esophagus | ESCC | 4.66e-10 | 2.08e-01 | 0.1327 |
10885 | WDR3 | P8T-E | Human | Esophagus | ESCC | 5.09e-07 | 6.84e-02 | 0.0889 |
10885 | WDR3 | P9T-E | Human | Esophagus | ESCC | 4.46e-09 | 2.02e-01 | 0.1131 |
10885 | WDR3 | P10T-E | Human | Esophagus | ESCC | 2.54e-19 | 2.02e-01 | 0.116 |
10885 | WDR3 | P11T-E | Human | Esophagus | ESCC | 9.88e-03 | 1.16e-01 | 0.1426 |
10885 | WDR3 | P12T-E | Human | Esophagus | ESCC | 3.44e-13 | 2.48e-01 | 0.1122 |
10885 | WDR3 | P15T-E | Human | Esophagus | ESCC | 1.42e-05 | 6.85e-02 | 0.1149 |
10885 | WDR3 | P16T-E | Human | Esophagus | ESCC | 4.36e-20 | 1.78e-01 | 0.1153 |
10885 | WDR3 | P19T-E | Human | Esophagus | ESCC | 2.57e-04 | 3.85e-01 | 0.1662 |
10885 | WDR3 | P20T-E | Human | Esophagus | ESCC | 1.16e-09 | 9.58e-02 | 0.1124 |
10885 | WDR3 | P21T-E | Human | Esophagus | ESCC | 3.64e-11 | 3.17e-01 | 0.1617 |
10885 | WDR3 | P22T-E | Human | Esophagus | ESCC | 2.81e-06 | 4.24e-02 | 0.1236 |
10885 | WDR3 | P23T-E | Human | Esophagus | ESCC | 4.61e-18 | 5.40e-01 | 0.108 |
10885 | WDR3 | P24T-E | Human | Esophagus | ESCC | 4.47e-10 | 1.11e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003112311 | Oral cavity | LP | RNA 3'-end processing | 48/4623 | 116/18723 | 5.51e-05 | 7.58e-04 | 48 |
GO:003112411 | Oral cavity | LP | mRNA 3'-end processing | 29/4623 | 62/18723 | 1.28e-04 | 1.49e-03 | 29 |
GO:000637811 | Oral cavity | LP | mRNA polyadenylation | 22/4623 | 44/18723 | 2.51e-04 | 2.63e-03 | 22 |
GO:004363111 | Oral cavity | LP | RNA polyadenylation | 22/4623 | 45/18723 | 3.77e-04 | 3.67e-03 | 22 |
GO:002261329 | Skin | cSCC | ribonucleoprotein complex biogenesis | 302/4864 | 463/18723 | 5.13e-72 | 3.22e-68 | 302 |
GO:004225428 | Skin | cSCC | ribosome biogenesis | 206/4864 | 299/18723 | 3.33e-55 | 1.04e-51 | 206 |
GO:000636424 | Skin | cSCC | rRNA processing | 156/4864 | 225/18723 | 1.42e-42 | 1.48e-39 | 156 |
GO:001607224 | Skin | cSCC | rRNA metabolic process | 158/4864 | 236/18723 | 4.06e-40 | 2.83e-37 | 158 |
GO:003447017 | Skin | cSCC | ncRNA processing | 215/4864 | 395/18723 | 6.83e-34 | 4.28e-31 | 215 |
GO:003466013 | Skin | cSCC | ncRNA metabolic process | 234/4864 | 485/18723 | 1.37e-26 | 4.77e-24 | 234 |
GO:004227429 | Skin | cSCC | ribosomal small subunit biogenesis | 59/4864 | 73/18723 | 1.39e-22 | 2.90e-20 | 59 |
GO:003049012 | Skin | cSCC | maturation of SSU-rRNA | 39/4864 | 50/18723 | 2.04e-14 | 1.40e-12 | 39 |
GO:00311234 | Skin | cSCC | RNA 3'-end processing | 58/4864 | 116/18723 | 2.47e-08 | 6.89e-07 | 58 |
GO:00311244 | Skin | cSCC | mRNA 3'-end processing | 34/4864 | 62/18723 | 1.27e-06 | 2.20e-05 | 34 |
GO:00063784 | Skin | cSCC | mRNA polyadenylation | 26/4864 | 44/18723 | 3.48e-06 | 5.29e-05 | 26 |
GO:00436314 | Skin | cSCC | RNA polyadenylation | 26/4864 | 45/18723 | 6.20e-06 | 8.78e-05 | 26 |
GO:00311235 | Thyroid | PTC | RNA 3'-end processing | 65/5968 | 116/18723 | 6.24e-08 | 1.30e-06 | 65 |
GO:00311245 | Thyroid | PTC | mRNA 3'-end processing | 40/5968 | 62/18723 | 1.28e-07 | 2.48e-06 | 40 |
GO:00436315 | Thyroid | PTC | RNA polyadenylation | 29/5968 | 45/18723 | 7.13e-06 | 8.38e-05 | 29 |
GO:00063785 | Thyroid | PTC | mRNA polyadenylation | 28/5968 | 44/18723 | 1.46e-05 | 1.56e-04 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR3 | SNV | Missense_Mutation | c.2075C>T | p.Ser692Leu | p.S692L | Q9UNX4 | protein_coding | deleterious(0) | benign(0.434) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
WDR3 | SNV | Missense_Mutation | c.1045N>G | p.Leu349Val | p.L349V | Q9UNX4 | protein_coding | deleterious(0.04) | possibly_damaging(0.556) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
WDR3 | SNV | Missense_Mutation | c.1462N>A | p.Leu488Met | p.L488M | Q9UNX4 | protein_coding | tolerated(0.07) | probably_damaging(0.952) | TCGA-B6-A0X4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
WDR3 | SNV | Missense_Mutation | novel | c.1681N>G | p.Gln561Glu | p.Q561E | Q9UNX4 | protein_coding | tolerated(0.31) | benign(0.179) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR3 | SNV | Missense_Mutation | rs367631829 | c.2719N>G | p.Arg907Gly | p.R907G | Q9UNX4 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-S3-AA17-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
WDR3 | SNV | Missense_Mutation | novel | c.1012N>C | p.Glu338Gln | p.E338Q | Q9UNX4 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
WDR3 | SNV | Missense_Mutation | novel | c.1502C>T | p.Ser501Phe | p.S501F | Q9UNX4 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WDR3 | SNV | Missense_Mutation | c.842N>C | p.Arg281Thr | p.R281T | Q9UNX4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
WDR3 | SNV | Missense_Mutation | novel | c.88N>G | p.Thr30Ala | p.T30A | Q9UNX4 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-AA-3520-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR3 | SNV | Missense_Mutation | rs773144364 | c.19N>C | p.Tyr7His | p.Y7H | Q9UNX4 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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