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Gene: VPS37C |
Gene summary for VPS37C |
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Gene information | Species | Human | Gene symbol | VPS37C | Gene ID | 55048 |
Gene name | VPS37C subunit of ESCRT-I | |
Gene Alias | VPS37C | |
Cytomap | 11q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A5D8V6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55048 | VPS37C | LZE4T | Human | Esophagus | ESCC | 1.12e-02 | 1.19e-01 | 0.0811 |
55048 | VPS37C | LZE24T | Human | Esophagus | ESCC | 2.37e-21 | 5.70e-01 | 0.0596 |
55048 | VPS37C | P1T-E | Human | Esophagus | ESCC | 2.74e-02 | 1.41e-01 | 0.0875 |
55048 | VPS37C | P2T-E | Human | Esophagus | ESCC | 4.08e-09 | 1.56e-01 | 0.1177 |
55048 | VPS37C | P4T-E | Human | Esophagus | ESCC | 4.20e-06 | 1.86e-01 | 0.1323 |
55048 | VPS37C | P5T-E | Human | Esophagus | ESCC | 2.15e-10 | 1.22e-01 | 0.1327 |
55048 | VPS37C | P8T-E | Human | Esophagus | ESCC | 1.45e-17 | 4.35e-01 | 0.0889 |
55048 | VPS37C | P9T-E | Human | Esophagus | ESCC | 1.26e-02 | 1.12e-01 | 0.1131 |
55048 | VPS37C | P10T-E | Human | Esophagus | ESCC | 5.83e-13 | 1.13e-01 | 0.116 |
55048 | VPS37C | P11T-E | Human | Esophagus | ESCC | 6.39e-10 | 3.59e-01 | 0.1426 |
55048 | VPS37C | P12T-E | Human | Esophagus | ESCC | 1.16e-20 | 2.48e-01 | 0.1122 |
55048 | VPS37C | P15T-E | Human | Esophagus | ESCC | 4.08e-14 | 2.09e-01 | 0.1149 |
55048 | VPS37C | P16T-E | Human | Esophagus | ESCC | 1.28e-09 | 1.48e-01 | 0.1153 |
55048 | VPS37C | P17T-E | Human | Esophagus | ESCC | 1.73e-08 | 3.30e-01 | 0.1278 |
55048 | VPS37C | P19T-E | Human | Esophagus | ESCC | 1.78e-08 | 4.75e-01 | 0.1662 |
55048 | VPS37C | P20T-E | Human | Esophagus | ESCC | 9.12e-06 | 2.48e-01 | 0.1124 |
55048 | VPS37C | P21T-E | Human | Esophagus | ESCC | 1.53e-18 | 2.60e-01 | 0.1617 |
55048 | VPS37C | P22T-E | Human | Esophagus | ESCC | 3.81e-03 | 4.61e-02 | 0.1236 |
55048 | VPS37C | P23T-E | Human | Esophagus | ESCC | 7.46e-16 | 3.26e-01 | 0.108 |
55048 | VPS37C | P24T-E | Human | Esophagus | ESCC | 3.57e-08 | 1.61e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0019058110 | Oral cavity | LP | viral life cycle | 161/4623 | 317/18723 | 5.99e-24 | 2.21e-21 | 161 |
GO:0006605110 | Oral cavity | LP | protein targeting | 156/4623 | 314/18723 | 5.43e-22 | 1.62e-19 | 156 |
GO:009015019 | Oral cavity | LP | establishment of protein localization to membrane | 128/4623 | 260/18723 | 7.19e-18 | 1.19e-15 | 128 |
GO:001623615 | Oral cavity | LP | macroautophagy | 135/4623 | 291/18723 | 4.71e-16 | 6.70e-14 | 135 |
GO:001605013 | Oral cavity | LP | vesicle organization | 128/4623 | 300/18723 | 4.96e-12 | 3.98e-10 | 128 |
GO:000703415 | Oral cavity | LP | vacuolar transport | 74/4623 | 157/18723 | 7.85e-10 | 3.70e-08 | 74 |
GO:003625713 | Oral cavity | LP | multivesicular body organization | 24/4623 | 31/18723 | 1.01e-09 | 4.68e-08 | 24 |
GO:003625813 | Oral cavity | LP | multivesicular body assembly | 23/4623 | 30/18723 | 3.19e-09 | 1.38e-07 | 23 |
GO:001906814 | Oral cavity | LP | virion assembly | 24/4623 | 35/18723 | 5.48e-08 | 1.88e-06 | 24 |
GO:000661211 | Oral cavity | LP | protein targeting to membrane | 60/4623 | 131/18723 | 1.10e-07 | 3.59e-06 | 60 |
GO:000703213 | Oral cavity | LP | endosome organization | 41/4623 | 82/18723 | 6.46e-07 | 1.73e-05 | 41 |
GO:003970213 | Oral cavity | LP | viral budding via host ESCRT complex | 16/4623 | 21/18723 | 1.02e-06 | 2.53e-05 | 16 |
GO:004675513 | Oral cavity | LP | viral budding | 18/4623 | 26/18723 | 2.13e-06 | 4.81e-05 | 18 |
GO:007266515 | Oral cavity | LP | protein localization to vacuole | 30/4623 | 67/18723 | 2.60e-04 | 2.71e-03 | 30 |
GO:004316211 | Oral cavity | LP | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 13/4623 | 23/18723 | 1.09e-03 | 9.03e-03 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VPS37C | SNV | Missense_Mutation | c.842N>C | p.Gly281Ala | p.G281A | A5D8V6 | protein_coding | tolerated(0.2) | benign(0) | TCGA-AR-A1AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
VPS37C | SNV | Missense_Mutation | novel | c.319N>A | p.Glu107Lys | p.E107K | A5D8V6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
VPS37C | SNV | Missense_Mutation | novel | c.304N>A | p.Asp102Asn | p.D102N | A5D8V6 | protein_coding | tolerated(0.46) | benign(0.409) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
VPS37C | SNV | Missense_Mutation | novel | c.493N>A | p.Glu165Lys | p.E165K | A5D8V6 | protein_coding | tolerated(0.15) | probably_damaging(0.914) | TCGA-VS-A8EI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
VPS37C | SNV | Missense_Mutation | c.824C>T | p.Thr275Ile | p.T275I | A5D8V6 | protein_coding | deleterious(0.02) | benign(0) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
VPS37C | SNV | Missense_Mutation | novel | c.838N>C | p.Ser280Pro | p.S280P | A5D8V6 | protein_coding | tolerated(0.16) | benign(0.424) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
VPS37C | SNV | Missense_Mutation | rs746228096 | c.20A>C | p.Lys7Thr | p.K7T | A5D8V6 | protein_coding | tolerated(0.05) | possibly_damaging(0.812) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
VPS37C | SNV | Missense_Mutation | c.812N>A | p.Gly271Asp | p.G271D | A5D8V6 | protein_coding | deleterious(0) | possibly_damaging(0.567) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
VPS37C | SNV | Missense_Mutation | c.473N>A | p.Arg158Lys | p.R158K | A5D8V6 | protein_coding | tolerated(0.17) | benign(0.005) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
VPS37C | SNV | Missense_Mutation | novel | c.409N>C | p.Ser137Pro | p.S137P | A5D8V6 | protein_coding | tolerated(0.17) | benign(0.406) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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